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Encyclopedia > Peramivir

Peramivir is a pharmaceutical drug used to viral infections. Like zanamivir and oseltamivir, peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. HHS Secretary Mike Leavitt announced on January 4, 2007 that the Department has awarded a $102.6 million, four-year contract to BioCryst Pharmaceuticals, Inc. for advanced development of their influenza antiviral drug, peramivir.[1] Image File history File links Information_icon. ... Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ... Oseltamivir (INN) (IPA: ) is an antiviral drug that is used in the treatment and prophylaxis of both Influenzavirus A and Influenzavirus B. Like zanamivir, oseltamivir is a neuraminidase inhibitor. ... Neuraminidase inhibitors are a class of antiviral drugs, whose mode of action relies on blocking the function of viral neuraminidase protein, thus preventing the virus from budding from the host cell. ... The transition state of a chemical reaction is a particular configuration along the reaction coordinate. ... Neuraminidase is a glycoside hydrolase enzyme (EC 3. ...


Experimental data indicate that peramivir may have useful activity against many viruses of interest, including H5N1 (avian bird flu) , hepatitis B, polio, measles and smallpox. Peramivir is active in a hamster model of yellow fever, a finding which is not surprising, given the familial relationship of yellow fever and hepatitis C viruses as flaviviridae. Peramivir is active against other important flaviviridae such as West Nile virus and dengue fever. Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... Hepatitis B is an inflammation of the liver and is caused by the Hepatitis B virus (HBV), a member of the Hepadnavirus family[1] and one of hundreds of unrelated viral species which cause viral hepatitis. ... Poliomyelitis (polio), or infantile paralysis, is a viral paralytic disease. ... Smallpox (also known by the Latin names Variola or Variola vera) is a highly contagious disease unique to humans. ... Hepatitis C is a blood-borne, infectious, viral disease that is caused by a hepatotropic virus called Hepatitis C virus (HCV). ... Genera Flavivirus Pestivirus Hepacivirus The Flaviviridae are a family of viruses that infect mammals. ... Genera Flavivirus Pestivirus Hepacivirus The Flaviviridae are a family of viruses that infect mammals. ... West Nile virus (WNV) is a virus of the family Flaviviridae; part of the Japanese encephalitis (JE) antigenic complex of viruses, it is found in both tropical and temperate regions. ... Dengue fever (IPA: ) and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics, with a geographical spread similar to malaria. ...


"Dr. Frederick Hayden of the University of Virginia recently presented unpublished data suggesting that peramivir may have the potential for use as single dose parenteral treatment or prophylaxis for influenza (Infectious Diseases Society of America Annual Meeting, San Francisco, October 6-9, 2005). In a talk on the use of antiviral drugs in the setting of an influenza pandemic, Dr. Hayden presented unpublished animal data that suggests that, due to its very long half life, peramivir, an investigational neuraminaidase inhibitor drug, maintains its anti-influenza activity for as long as 10 days following a single intravenous dose. [...] BioCryst's CEO, Charles Bugg, was quoted in the New York Times as saying that peramivir is much easier and cheaper to produce than Tamiflu and that 8 million doses could be produced quickly. In 6-9 months production could be scaled up to 10 million doses per month."[2]


Image:peramivir.png Image File history File links No higher resolution available. ...


(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethyl-butyl]-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid


CAS number 229614-55-5; 330600-85-6 CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ...


Sources

  1. ^ HHS
  2. ^ Biocryst
  • http://www.upmc-biosecurity.org/website/flu_update/content/cbn_flu/2005-10-03_cbn_revclinH5N1.html
  • http://www.upmc-biosecurity.org/website/flu_update/content/cbn_flu/2005-10-12_cbn_peramivir.html
  • http://www.idsociety.org/Content/ContentGroups/Committees1/Standards_and_Practice_Guidelines/Influenza_Panel/Mishin_VP_et_al_2005.pdf

  Results from FactBites:
 
Peramivir Information (334 words)
Like zanamivir and oseltamivir, peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells.
Peramivir is active in a hamster model of yellow fever, a finding which is not surprising, given the familial relationship of yellow fever and hepatitis C viruses as flaviviridae.
Peramivir is active against other important flaviviridae such as West Nile virus and dengue fever.
  More results at FactBites »

 
 

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