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Encyclopedia > Pentagastrin

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ... In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Secretion is the process of segregating, elaborating, and releasing chemicals from a cell. ... Gastric acid is, together with several enzymes and the intrinsic factor, one of the main secretions of the stomach. ... Pepsin is a protease, a digestive enzyme that degrades food proteins in the stomach. ... Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. ... Diagnosis (from the Greek words dia = by and gnosis = knowledge) is the process of identifying a disease by its signs, symptoms and results of various diagnostic procedures. ...


Pentagstrin's IUPAC chemical name is "L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl". IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC). ...


  Results from FactBites:
 
Drug Information: Pentagastrin (Diagnostic) (Print Version) (793 words)
Pentagastrin (pen-ta-GAS-trin) is a testing agent used to help diagnose problems or disease of the stomach.
Pentagastrin is used only under the supervision of a doctor.
There is no specific information comparing use of pentagastrin in the elderly with use in other age groups.
The effect of pentadecapeptide BPC 157, H2-blockers, omeprazole and sucralfate on new vessels and new granulation ... (824 words)
Maximal pentagastrin stimulated acid output was halved by 20 mg omeprazole daily and 84% inhibited by 40 mg daily.
Pepsin output after pentagastrin was little altered but with the reduced secretory volume pepsin concentrations were increased by both doses.
Pentagastrin infused intravenously produced a dose-dependent increase of GMBF as well as acid secretion, and its effect reached a maximum at 120 microgram/kg/hr (maximal dose).
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