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Encyclopedia > Pefloxacin
Pefloxacin chemical structure
Systematic (IUPAC) name
1-ethyl-6-fluoro-7- (4-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid
CAS number 70458-92-3
ATC code J01MA03
PubChem 51081
DrugBank APRD00108
Chemical data
Formula C17H20FN3O3
Mol. weight 333.358 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 20-30%
Metabolism  ?
Half life 8.6 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Pefloxacin is a fluoroquinolone antibiotic. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ... An antibiotic is a drug that kills or slows the growth of bacteria. ...

Quinolones (J01M) edit

Ciprofloxacin, Enoxacin, Fleroxacin, Gatifloxacin, Gemifloxacin, Grepafloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Norfloxacin, Ofloxacin, Pefloxacin, Prulifloxacin, Rufloxacin, Sparfloxacin, Temafloxacin, Trovafloxacin, Sitafloxacin Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ... Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand names Cipro and Ciproxin (and other brand names in other markets, e. ... Enoxacin (Enroxil, Penetrex) is an oral broad-spectrum quinoline antibacterial agent used in the treatment of urinary tract infections and gonorrhea. ... Gatifloxacin is an antibiotic of the fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and Topoisomerase IV. Bristol-Myers Squibb introduced Gatifloxacin in 1999 under the proprietary name Tequin for the treatment of respiratory tract infections, having licensed the medication from Kyorin Pharmaceutical... Gemifloxacin mesylate (Factive, Oscient Pharmaceuticals) is an oral broad-spectrum quinoline antibacterial agent used in the treatment of bronchitis and pneumonia. ... Grepafloxacin hydrochloride (marketed as Raxar by Glaxo Wellcome) is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. ... Levofloxacin is relatively new fluoroquinolone antibiotic, marketed by Ortho-McNeil under the brand name Levaquin. ... Lomefloxacin hydrochloride (Maxaquin) is a quinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. ... Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. ... Norfloxacin is an oral broad-spectrum quinoline antibacterial agent used in the treatment of urinary tract infections. ... Ofloxacin sold under the brand name Floxin in the US. It is a quinolone antibiotic. ... Trovafloxacin (sold as Trovan by Pfizer) is a broad spectrum antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV [1]. It is not used widely due to the risk of hepatotoxicity. ...

Other quinolones:

Cinoxacin, Flumequine, Nalidixic acid, Oxolinic acid, Pipemidic acid, Piromidic acid, Rosoxacin Cinoxacin is a quinolone antibiotic used primarily to treat urinary tract infections. ... Nalidixic acid is the basis for quinolone antibiotics. ...

  Results from FactBites:
The Fluoroquinolone Toxicity Research Foundation (827 words)
It acts thereby around an uncomplicated Zystitis and to the prophylaxis, thus vorbeugung, with operational interferences at the urethra with patients, with whom a increased danger of infections exists.
Pefloxacin belongs to the group of active substances of the Gyrasehemmer.
Pefloxacin and Nitrofurantoin can obstruct themselves in their effect.
  More results at FactBites »



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