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Encyclopedia > Ohmefentanyl
Chemical structure of Ohmefentanyl
Ohmefentanyl
Systematic (IUPAC) name
N-[β-Hydroxy-β-Phenethyl]-3-Methyl-4-Phenpropamido-Piperidine
Identifiers
CAS number 78995-14-9
ATC code N01AH N02AB
PubChem 62279
Chemical data
Formula C23H30N2O2 
Mol. mass 366.5022
Physical data
Melt. point 188 °C (370 °F)
Pharmacokinetic data
Bioavailability ~25% oral
Metabolism Liver
Half life ~90 min
Excretion Urine
Therapeutic considerations
Pregnancy cat.

? Image File history File links Download high-resolution version (1132x629, 20 KB) drew this image I, the creator of this work, hereby release it into the public domain. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... The melting point of a crystalline solid is the temperature at which it changes state from solid to liquid. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status

Schedule I(US) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970. ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Routes TD, IM, IV, oral, sublingual, buccal

Ohmefentanyl (OMF) is an extremely potent, fully synthetic opioid with μ-receptor subtype specificity.[1][2] In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... An opioid is a chemical substance that has a morphine-like action in the body. ... To meet Wikipedias quality standards, this article may require cleanup. ...

Contents

Discovery

The 3-Me analog of fentanyl (3-MeF) was first introduced by Paul Janssen[3] which has recently resurfaced in the scientific literature by Slavic researchers.[4] QSAR reveals that the βOH was first incorporated into 3-MeF because this pharmacophore had previously been shown to boost the activity of closely-related piperidine based narcotics[5] e.g. phenoperidine. OMF was invented by the Chinese in 1979.[6] The synthesis and preliminary evaluation of the individual isomers of OMF was reported independently by Chinese and American scientists in 1995.[7][8] There are complex distinctions that can be drawn between the subsequent isomers through studying their pharmacology. In chemistry a methyl-group is a hydrophobic Alkyl functional group which is derived from methane (CH4). ... To meet Wikipedias quality standards, this article or section may require cleanup. ... Dr Paul Janssen was born in 1926, the son of a Flemish general practitioner. ... Distribution of Slavic people by language The Slavic peoples (Greek: , Latin: , Arabic: ‎ Saqaliba, Old Church Slavonic: , Russian: , Polish: , Serbian: ), Croatian: , Bulgarian: ) are a linguistic and ethnic branch of Indo-European peoples, living mainly in Europe, where they constitute roughly a third of the population. ... QSAR (Quantitative Structure-Activity Relationship, sometimes the A stands also for Affinity=reactivity) is the quantitative correlation of the biological (ecological, toxicological or pharmacological) activity to the structure of chemical compounds, which allows the prediction of the so-called drug efficacy of a structurally related compound. ... This prefix in chemical nomenclature indicates the presence of a hydroxyl functional group (-OH). ... A pharmacophore is a three-dimensional substructure of a molecule that carries (phoros) the essential features responsible for a drugs (pharmacon) biological activity. ... R-phrases , , S-phrases , , , , Flash point 16 °C RTECS number TM3500000 Related compounds Related compounds pyridine pyrrolidine piperazine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Piperidine is an organic compound with the molecular formula C5H11N... The term narcotic, derived from the Greek word for stupor, originally referred to a variety of substances that induced sleep (such state is narcosis). ... Phenoperidine is an opiod general anesthetic. ... In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ... Pharmacology (in Greek: pharmacon (φάρμακον) meaning drug, and logos (λόγος) meaning science) is the study of how substances interact with living organisms to produce a change in function. ...


Nomenclature

Ohmefentanyl implies hydroxy (OH) methyl (Me) F. β3HOMeF is the long–time 1st generation example of this.[9] Ohmefentanyl originally referred to the unresolved (3R,4S) pair of OMF isomers. RTI-1abcd is the RTI code for a mixture of the four cis isomers of β3HOMeF.[10] β4HOMeF (Pharaohfentanyl) is the New-Millenium positional isomer of β3HOMeF (OMF2), which is in itself an extension of 4-MeF, a novel Slav invention.[11] Nomenclature refers to a method of assigning (unique) names. ... Structural isomerism (or constitutional isomerism) is a form of isomerism in which molecules with the same molecular formula have atoms bonded together in different orders, as opposed to stereoisomerism. ... A novel (from French nouvelle Italian novella, new) is an extended, generally fictional narrative, typically in prose. ... An invention is an object, process, or technique which displays an element of novelty. ...


QSAR

3-MeF has 2 chiral carbons and exists as a enantiomeric pair of diastereomers. The cis-diastereomer is ~4 x more active than the trans-diasteromer. In the case of (±)-cis-3-MeF, activity lies exclusively with the (+)-isomer. The worthless (–)-isomer serves a negative role in the world of undermining the positive effects of the (+)-isomer. QSAR (Quantitative Structure-Activity Relationship, sometimes the A stands also for Affinity=reactivity) is the quantitative correlation of the biological (ecological, toxicological or pharmacological) activity to the structure of chemical compounds, which allows the prediction of the so-called drug efficacy of a structurally related compound. ... The term chiral (pronounced ) is used to describe an object which is non-superimposable on its mirror image. ... In chemistry, enantiomers are stereoisomers that are mirror images of each other. ... Diastereomers (or diastereoisomers) are stereoisomers that are not enantiomers (mirror images of each other). ... Diastereomers (or diastereoisomers) are stereoisomers that are not enantiomers (mirror images of each other). ... Diastereomers (or diastereoisomers) are stereoisomers that are not enantiomers (mirror images of each other). ...

3-MF / OMF QSAR [Data taken from J.Med.Chem. V38, pp3652–3659]
Cmpd. absol config mp°C [α]25D(deg)(MeOH) analgesic ED50 (mg/kg) rel potency, morphine=1
(+)-cis-1a S,3R,4S) 117–119 +19.79 0.00106 13110
(–)-cis-1b R,3R,4S) 135–137 -31.91 0.0046 2990
(–)-trans-1c S,3R,4R) 107–109 -0.49 0.0097 1450
(+)-trans-1d S,3S,4S) 98–100 +62.24 0.014 985
(–)-trans-1e R,3R,4R) 98–100 -58.11 0.014 980
(+)-trans-1f R,3S,4S) 107–108 +0.78 0.0710 196
(±)-cis-1ah 0.0022 6320
(±)-cis-1bg 0.014 985
(+)-cis-3-MeF 0.00767 1812
(–)-cis-3-MeF 0.910 15
  • For cis OMF, there is also 2 possible configurations about the piperidine ring [(3R,4S) and (3S,4R)], although somewhat unfortunately, the (3S,4R) enantiomer is worthless, so you may be tempted to remove it from the final product. Usually this is done via fractional crystallization. Also the differing retention factors of the cis/trans isomers means they can be separated by flash chromatography. In Serbia they like to use Al2O3. This is commonly called REVERSE PHASE chromatography. The fentanyl precursor contains 2 nitrogens, so it streaks excessively making separation difficult.
  • In addition to the piperidine ring stereochemistry, the β-phenethanol tail also has a chiral carbon and hence, possesses a center of asymmetry. Thus OMF has 23 = 8 possible stereoisomers, ie. four racemic diastereomers.
  • You are at the very least going to want to separate the cis/trans isomers. Im not saying you actually have the ability to separate out the isomers, but on an academic level, you should at least appreciate that this is the gold-standard you should aim for.
  • RTI-4614-4 is reasonably potent, but better compounds can be produced.
  • Either the 1ab or the 1ah combination can be made depending on the synthetic tools are employed.

R-phrases , , S-phrases , , , , Flash point 16 °C RTECS number TM3500000 Related compounds Related compounds pyridine pyrrolidine piperazine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Piperidine is an organic compound with the molecular formula C5H11N... In chemistry, Fractional Crystallization is a method of refining substances based on differences in soluability. ... Anthem Serbia() on the European continent() Capital (and largest city) Belgrade Official languages Serbian written with the Cyrillic alphabet1 Government Parliamentary republic  -  President Boris Tadić  -  Prime Minister Vojislav KoÅ¡tunica Establishment  -  Formation 8th century   -  Independence c. ... R-phrases , , S-phrases , , , , Flash point 16 °C RTECS number TM3500000 Related compounds Related compounds pyridine pyrrolidine piperazine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Piperidine is an organic compound with the molecular formula C5H11N... The different types of isomers. ... The term chiral (pronounced ) is used to describe an object which is non-superimposable on its mirror image. ... Symmetry is a characteristic of geometrical shapes, equations and other objects; we say that such an object is symmetric with respect to a given operation if this operation, when applied to the object, does not appear to change it. ... ... In chemistry, a racemate is a mixture of equal amounts of left- and right-handed stereoisomers of a chiral molecule. ... Diastereomers (or diastereoisomers) are stereoisomers that are not enantiomers (mirror images of each other). ...

Pharmacological ramble

  • It is important to make the distinction that the aim is not merely trying to boost potency, as the fentanyl derivatives are already quite strong (~50-100 x Mor). Enantiopure F9204, has an optimized pharmacological profile, including dependence ratio and associated factors. There are many examples in the pharmaceutical industry that labor this important concept, e.g. nearly all antidepressants on the market are enantiopure. For instance Lexapro was initially sold as racemic citalopram but was then revised to enantiopure Escitalopram, because it helped discriminate against unwanted side-effects. Each stereoisomer shares common physical properties e.g. NMR, GCMS, mp, IR etc. but has opposite effect on optical rotation, and the X-ray crystallography spectrum yields a perfect reflection.
OMF Dependence Potency Index
Cmpd. Withdrawal Jumping Culmulative ED50 (mg/kg) Dependence Potency Index
(+)-cis-1a 0.0984 92.8
(–)-cis-1b 0.0007 0.15
(–)-trans-1c 0.0445 4.6
(+)-trans-1d 0.0303 2.2
(–)-trans-1e 0.361 5.0
(+)-trans-1f 0.383 5.1
  • Dependence potency index was obtained by withdrawal jumping cumulative ED50/analgesic ED50.[12]

Super-potent fentanyl analogues such as Ohmefentanyl might well be more potent toxins than nerve agents such as VX. In chemistry two stereoisomers are said to be enantiomers if one can be superimposed on the mirror image of the other. ... Pharmacology (in Greek: pharmacon is drug, and logos is science) is the study of how chemical substances interfere with living systems. ... This is a list of pharmaceutical and biotech companies that are major manufacturers on global or national markets : Abbott Laboratories Able Laboratories Akzo Nobel Allergan Almirall Prodesfarma Alphapharm Altana (previously Byk Gulden) ALZA, part of Johnson & Johnson Amgen AstraZeneca, formed from the merger of Astra AB and Zeneca Group PLC... In chemistry two stereoisomers are said to be enantiomers if one can be superimposed on the mirror image of the other. ... Escitalopram oxalate (also known as LexaproTM and CipralexTM) is a medication developed by the Danish pharmaceutical company Lundbeck, that acts as a selective serotonin reuptake inhibitor or SSRI. It is typically used as an antidepressant to treat depression associated with mood disorders although also may be used in the treatment... In chemistry, a racemate is a mixture of equal amounts of left- and right-handed stereoisomers of a chiral molecule. ... Citalopram is an antidepressant drug used to treat depression associated with mood disorders. ... In chemistry two stereoisomers are said to be enantiomers if one can be superimposed on the mirror image of the other. ... This article or section does not cite its references or sources. ... Antonym of psychical. ... Pacific Northwest National Laboratorys high magnetic field (800 MHz, 18. ... Gas chromatography-mass spectrometry (GC-MS) is a method that combines the features of gas-liquid chromatography and mass spectrometry to identify different substances within a test sample. ... The melting point of a crystalline solid is the temperature at which it changes state from solid to liquid. ... Infrared spectroscopy (IR Spectroscopy) is the subset of spectroscopy that deals with the IR region of the EM spectrum. ... When polarized light is passed through a substance containing chiral molecules (or nonchiral molecules arranged asymmetrically), the direction of polarization can be changed. ... X-ray crystallography or single-crystal X-ray diffraction is an analytical technique which uses the diffraction pattern produced by bombarding a single crystal with X-rays to solve the crystal structure. ... Look up reflection in Wiktionary, the free dictionary. ... The VX nerve agent is the most well-known of the V-series of nerve agents. ...


The Most Potent Opioid[13]

1a is 13K x stronger than morphine. If a p-F atom is then incorporated into the phenethanol tail, the resultant compound has recently been reported to have a potency of 18K x morphine. p-F-1b was also 4K x stronger than morphine. Hence, upon p-F incorporation, the two most important OMF isomers are both increased in potency by ~13rd. Up until the resolution and exploration of the individual isomers of OMF had been accomplished, carfentanil was popularly interpreted as most potent opioid ever invented (~30 x stronger than fentanyl).[14] This is in fact the same order of potency as OMF unresolved.[15] Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1...

  • Whereas these totally-synthetic fentanyl analogs show remarkable μ-specificity, some of the high potency semi-synthetic alkaloids are nonselective agonists at μ-, δ- and κ-opioid receptors. Dihydroetorphine (DHE ~6000 x morphine) and the 14-phenylpropoxy derivatives of various morphinans (e.g. oxymorphone) are illustrative examples of this.title

More research needs to be done in order to assess if mixed-agonists are a good/bad thing. Heroin, for example is likely to be a mixed-agonist. Such compounds are in a sense victims of their own success; their extreme potency has meant that they are commonly regarded as too dangerous for human consumption and instead have been applied to veterinary medicine for the immobilization of wild animals. Nevertheless, it deserves mention that there are numerous indications for DHE being used on humans.[16] This implies that there is the potential to use them on humans if the, err, pharmacological justifications can be secured. Generally, synthetic means pertaining to synthesis, i. ... Semisynthesis or partial chemical synthesis uses compounds isolated from natural sources (e. ... An alkaloid is a nitrogenous organic molecule that has a pharmacological effect on humans and other animals. ... Oxymorphone (Opana, Numorphan) or 14-Hydroxydihydromorphinone is a powerful semi-synthetic opioid analgesic that is derived from thebaine, and is approximately 6-8 times more potent than morphine. ... Heroin ((INN) Diacetylmorphine , (BAN) diamorphine) is a semi-synthetic opioid. ... Erectile dysfunction, also known as impotence, is the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. ... For other uses, see Risk (disambiguation). ... Veterinary medicine is the application of medical, diagnostic, and therapeutic principles to companion, domestic, exotic, wildlife, and production animals. ... Immobilization in soil science, is when organic matter decomposes and is absorbed by micro-organisms, therefore preventing it being accessible to plants [1]. Immobilization is the alternative to mineralization. ... Wild, in zoology or botany, is a rough if problematic antonym to domesticated: see wildlife. ... Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ...


Time Release Formulation: Fluorogesic

Professor Q speculates —"there is a good chance that this compound could be made more powerful still, by addition of an α-Me. Although unlikely to increase affinity as such, it would greatly "harden" the agent against metabolic attack, since, as is the case with fentanyl, I would assume N-dealkylation of the piperidine to be the predominant pathway of liver microsomal breakdown. Even if ED50 doesn't go any lower, one would expect duration of action to increase by a factor of three or so...".Opioids.com However, α-Me-OMF is even weaker than trans-3-MeF.[17] The propionate salt of testosterone has a longer duration of action than the free alcohol, this analogy might be applicable to RTI-4614-4. While the propionate reverse ester is reported to be only ≈15th the potency of OMF, it would gradually hydrolyze to the alcohol in vivo thereby providing a steady and controlled release of OMF into the bloodstream, resulting in the increased duration of analgesia that is required. Thus it is tentative to presume that 3x the dose could be consumed in the form of the propionate reverse ester which might possibly be effective in the formulation of a time release version of OMF. In the case of the dopamine reuptake inhibitor vanoxerine and the antipsychotic haloperidol, converting the vacant hydroxyl to decanoate reverse esters yields remarkably long-acting agents with a duration of ~2–4 weeks. It is advised that an ether FG is an preferred embodiment of the invention, due to the fact that it is less susceptible to hydrolysis and is also slightly more lipophilic Et2O vs. EtOAc. Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος(metavallo), the Greek word for change), in the most general sense, is the ingestion and breakdown of complex compounds, coupled... To meet Wikipedias quality standards, this article or section may require cleanup. ... This article or section does not adequately cite its references or sources. ... R-phrases , , S-phrases , , , , Flash point 16 °C RTECS number TM3500000 Related compounds Related compounds pyridine pyrrolidine piperazine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Piperidine is an organic compound with the molecular formula C5H11N... In cell biology, a microsome is a small vesicle that is derived from fragmented endoplasmic reticulum produced when cells are homogenized. ... The propionate (also propanoate) ion is C2H5COO− (propionic acid minus one hydrogen ion). ... Testosterone is a steroid hormone from the androgen group. ... The propionate (also propanoate) ion is C2H5COO− (propionic acid minus one hydrogen ion). ... Erectile dysfunction, also known as impotence, is the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. ... Hydrolysis is a chemical process in which a molecule is cleaved into two parts by the addition of a molecule of water. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... A duration is an amount of time or a particular time interval. ... For other uses of painkiller, see painkiller (disambiguation) An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain. ... Sustained-release (SR), extended-release (ER, XR, or XL), time-release or timed-release, controlled-release (CR), or continuous-release (CR or Contin) tablets are pills formulated to dissolve slowly and release a drug over time. ... This does not cite its references or sources. ... Vanoxerine, also known as GBR-12909, is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. ... The term antipsychotic is applied to a group of drugs used to treat psychosis. ... The decanoate ion is the conjugate base of decanoic acid, with formula C9H19COO−. Decanoate compounds include salts and esters of decanoic acid, such as sodium decanoate or methyl decanoate. ... A duration is an amount of time or a particular time interval. ... Ether is the general name for a class of chemical compounds which contain an ether group — an oxygen atom connected to two (substituted) alkyl groups. ... An invention is an object, process, or technique which displays an element of novelty. ... Hydrolysis is a chemical reaction or process in which a chemical compound reacts with water. ... This article or section does not cite its references or sources. ... Ether is the general name for a class of chemical compounds which contain an ether group — an oxygen atom connected to two (substituted) alkyl groups. ... Ethyl acetate, also known as acetic acid ethyl ester, ethyl ethanoate, acetic ether or acetic ester, is a clear, flammable liquid with a characteristic, not unpleasant smell like certain glues or nail polish removers. ...


These formulations are representative of so-called prodrugs, but the variety in which an inactive drug is metabolized to an active, not the variety where an already active compound maybe metabolized into another active secondary compound, that possesses radically different pharmacology to the first compound.[18]

  • Depot injections must not be taken intravenously, and are suitable only for subcutaneous or intramuscular injection(?)
  • A recent patent states that "The present invention provides a stereo-isomer of 3-methyl fentanyl derivative. The pharmacological research shows that it possesses obvious pain-stopping activity, and its action time is long and its addiction is low. Its pain-stopping effect is thousands times that of morphine." However this patent is only available in Chinese.[19]

// An injection is a method of putting liquid into the body with a hollow needle and a syringe which is pierced through the skin long enough for the material to be forced into the body. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... The subcutis is the layer of tissue directly underlying the cutis. ... Intramuscular injection is an injection of a substance directly into a muscle. ...

Cyclohexanol Fentanyl Analogs

More on Derivatized Fentanyl Analogs

Carfentanil is one of a long—string of piperidine drugs commercialized by Janssen Pharmaceutica. Its chemical structure is identical to fentanyl, except for the presence of a –CO2Me FG. Carfentanil is ~30 x stronger than fentanyl, and hence a powerful opioid.[20] Although carfentanil's reputation has been bastardized, the common precursor is also relevant to the synthesis of other, pharmaceutically important analogs, such as sufentanil, alfentanil and remifentanil.[21] These are routinely used agents in the arena of surgical anesthesia, but sufentanil is also be used post-operatively as a tranquilizer and is is not just resitricted to theater.[22] Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1... R-phrases , , S-phrases , , , , Flash point 16 °C RTECS number TM3500000 Related compounds Related compounds pyridine pyrrolidine piperazine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Piperidine is an organic compound with the molecular formula C5H11N... Many drugs are provided in tablet form. ... ... Johnson & Johnson NYSE: JNJ is an international pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1885. ... Chemical structure refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together. ... Absolutely the same, indistinguishable. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... In organic chemistry, functional groups are specific groups of atoms within molecules, that are responsible for the characteristic chemical reactions of those molecules. ... Sufentanil is a drug that belongs to the class of drugs known as the opioid analgesic drugs. ... Alfentanil (Alfenta) is a parenteral short-acting opioid painkiller, used for anaesthesia in surgery. ... Remifentanil is a potent ultra short-acting synthetic opioid analgesic drug. ... Anesthesia or anaesthesia (see spelling differences) has traditionally meant the condition of having the perception of pain and other sensations blocked. ... A sedative is a drug that depresses the central nervous system (CNS), which causes calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ...


Carfentanil has a high therapeutic index. However in a real-world environment, the dosage is very small, with the effect that those abusing the substance without experience of handling strong pharmaceuticals (particularly opiates) fact a high risk of an overdose. Like most opiates, in the event of overdose, respiratory syndrome can have life-threatening consequences. Even if the victim is successfully resuscitated, they may suffer brain damage resulting from oxygen deprivation. Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1... The therapeutic index of a medication is a comparison of the amount that causes the therapeutic effect to the amount that causes toxic effects. ... The real world is a colloquial term for the physical reality of everyday life which everyone experiences (see human condition). ... In pharmacology an effective dose is the amount of drug that produces a therapeutic response in 50% of the people taking it. ... Brain damage or brain injury is the destruction or degeneration of brain cells. ... This page may meet Wikipedias criteria for speedy deletion. ...


4-HOCH2-F shares the same molecular formula as OMF. Although it is not thought to be favorably bioactive in its own right, it still serves as a platform on which to build more complex analogs,[23] such as the MOM product. Insertion of an α-Me into this molecule will increase duration/intensity ~2 x. Organometallic addition of XMEt to the the trapped–intermediate of the Strecker amino acid synthesis gives a pharmacophore common to both methadone and ketobemidone. Such SAR overlap is thus likely and might be expected to have a favorable outcome with regards to creating unexplored agents with a longer duration.[citation needed] A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... Dimethyl ether, also known as methoxymethane, methyl ether, wood ether, and DME, is a colorless gaseous ether with with an ethereal smell. ... Organometallic have classically been compounds having bonds between one or more metal atoms and one or more carbon atoms of an organyl group. ... The halogens or halogen elements are a series of nonmetal elements from Group 17 (old-style: VII or VIIA; Group 7 IUPAC Style) of the periodic table, comprising fluorine, F, chlorine, Cl, bromine, Br, iodine, I, and astatine, At. ... Hot metal work from a blacksmith In chemistry, a metal (Greek: Metallon) is an element that readily loses electrons to form positive ions (cations) and has metallic bonds between metal atoms. ... Ethyl is a two-carbon substituent in organic chemistry. ... The Strecker amino acid synthesis is a series of chemical reactions that synthesize an amino acid from an aldehyde (or ketone). ... A pharmacophore is a three-dimensional substructure of a molecule that carries (phoros) the essential features responsible for a drugs (pharmacon) biological activity. ... Methadone is a synthetic opioid, used medically as an analgesic and in the treatment of narcotic addiction. ... Ketobemidone structure Ketobemidone is a powerful opioid analgesic. ...


Further examples of compounds bearing the same molecular formula OMF can be found on PubMed but will mostly point in the direction of variously substituted benzimidazole type agents. A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... Benzimidazole is a heterocyclic aromatic organic compound. ...


References

  1. ^ [1]J. Med. Chem.; 1995; 38(18); 3652-3659.
  2. ^ [2] J. Med. Chem.; 1995; 38(9); 1547-1557
  3. ^ [3] J. Med. Chem.; 1974; 17(10); 1047-1051
  4. ^ [4] J. Serb. Chem.; 2004; 69(7) 511-526
  5. ^ [5] J. Med. Chem.; 1962; 5(5); 913-919
  6. ^ [6] Scienta Sinica Vol. XXIV No. 5 pp 710-721 (May 1981)
  7. ^ [7]J. Med. Chem.; 1995; 38(18); 3652-3659.
  8. ^ [8] J. Med. Chem.; 1995; 38(9); 1547-1557
  9. ^ [9] Scienta Sinica Vol. XXIV No. 5 pp 710-721 (May 1981)
  10. ^ [10] J. Pharmacol. Exp. Ther. 2000 292: 1127-1134
  11. ^ [11] Bioorg. Med. Chem. Lett. 10 (2000) 2011-2014
  12. ^ [12] Life Sciences Volume 67, Issue 2, 2 June 2000, Pages 113-120
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External links

  • Links to external chemical sources
  • http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

 
 

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