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Encyclopedia > Nucleoside analogues

Nucleoside analogues are a range of antiviral products used to prevent viral replication in infected cells. The most commonly used is Aciclovir. They work by incorporating into the elongating DNA strands and terminating the extension process. Viral phenomena are objects or phenomena able to reproduce themselves or convert other objects into copies of themself when other objects are exposed to it. ... Aciclovir (INN) or acyclovir (USAN), marketed as Zovirax®, is one of the main antiviral drugs. ... Space-filling model of a section of DNA molecule Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions specifying the biological development of all cellular forms of life (and many viruses). ...


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Hepatitis B: Treatment Strategies for Currently Available Drugs (3932 words)
Combined nucleoside analogue treatment may have additive or synergistic antiviral effects if the nucleoside analogues use different pathways for intracellular activation, compete with different naturally occurring nucleotides for HBV polymerase, act on different viral subpopulations, or act at different sites in the replication cycle of HBV.
In light of these observations and in consideration of the fact that nucleoside analogues and interferon have different mechanisms of action, it is reasonable to evaluate combination therapy with one or more nucleosides in combination with interferon.
Virologic responses, however, are often incomplete with nucleoside analogues; these drugs have to be given for considerably longer periods of time (1 to 2 years) than interferon to induce a lasting virologic response.
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