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Encyclopedia > Nissl body
Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.
Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.

A Nissl body (or Nissl granule or tigroid body) is a large granular body found in nerve cells. It was named after Franz Nissl, German neurologist (1860-1919). Image File history File linksMetadata Download high resolution version (973x684, 234 KB)Nissl Stained section through the rodent hippocampus. ... Image File history File linksMetadata Download high resolution version (973x684, 234 KB)Nissl Stained section through the rodent hippocampus. ... Suborders Sciuromorpha Castorimorpha Myomorpha Anomaluromorpha Hystricomorpha Rodentia is an order of mammals (Mammalia). ... The hippocampus is located in the medial temporal lobe of the brain. ... Franz Nissl Franz Nissl (1860-1919) was born in Frankenthal in the Bavarian Palatinate, the son of Theodor Nissl and Maria Haas. ...

Nissl bodies can be demonstrated by selective staining, which was developed by Nissl and was an aniline stain used to label extranuclear RNA granules. Aniline, phenylamine or aminobenzene (C6H5NH2) is an organic chemical compound which is a primary aromatic amine consisting of a benzene ring and an amino group. ... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ...

These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis. The endoplasmic reticulum (endoplasmic meaning within the cytoplasm, reticulum meaning little net) or ER is an organelle found in all eukaryotic cells that is an interconnected network of tubules, vesicles and cisternae that is responsible for several specialized functions: Protein translation, folding, and transport (e. ... Figure 1: Ribosome structure indicating small subunit (A) and large subunit (B). ...

Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis). A feature of cells undergoing necrosis, or cell death caused by irreversible cell damage. ...


See also


Franz Nissl Franz Nissl (1860-1919) was born in Frankenthal in the Bavarian Palatinate, the son of Theodor Nissl and Maria Haas. ...

External links

  • MeSH Nissl+Bodies
  • Who Named It synd/2902
  • Histology at BU 04103loa - "Nervous Tissue and Neuromuscular Junction: spinal cord, cell bodies of anterior horn cells"
  • Labeled photo at mun.ca (halfway down page)
  • Tissues containing Nissl bodies at harvard.edu
Nervous tissue - edit
Neurons (gray matter): soma, axon (axon hillock, axoplasm, axolemma, neurofibril/neurofilament), dendrite (Nissl body, dendritic spine)
types (bipolar, pseudounipolar, multipolar, pyramidal, Purkinje, Renshaw, granule)

Synapses: neuropil, boutons, synaptic vesicle, neuromuscular junction, electrical synapse Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Who Named It is a Norwegian database of several thousand eponymous medical signs and the doctors associated with their identification. ... For the unrelated Jesuit university in Chestnut Hill, see Boston College. ... Nervous tissue is the fourth major class of vertebrate tissue. ... Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ... Grey matter is a category of nervous tissue with many nerve cell bodies and few myelinated axons. ... The soma is the bulbous end of a neuron, containing the nucleus. ... An axon, or nerve fiber, is a long slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neurons cell body or soma. ... The axon hillock is the anotomical part of a neuron that connects the cell body to the axon. ... Axoplasm is the cytoplasm of the axon of a neuron. ... The axolemma is the membrane of a neurons axon. ... Intermediate filaments are one component of the cytoskeleton - important structural components of living cells. ... The term Dendrite stems from the Greek word dendron (literally “tree”), and typically refers to the branched projections of a neuron that act to conduct the electrical stimulation received from other cells to and from the cell body, or soma of the neuron from which the dendrites project. ... Close up of the dendrite of a striatal medium spiny neuron. ... As a part of the retina, the bipolar cell exists between photoreceptors (rod cells and cone cells) and ganglion cells. ... Pseudounipolar cells (Pseudo- false, uni- one) are sensory neurons in the peripheral nervous system. ... The multipolar neuron possesses a single (usually long) axon and many dendrites, allowing for the integration of a great deal of information from other neurons. ... A pyramidal cell is a multipolar neuron located in the hippocampus and cerebral cortex. ... Drawing of pigeon Purkinje cells (A) by Santiago Ramon y Cajal Purkinje cells are a class of GABAergic neuron located in the cerebellar cortex. ... Renshaw cells are located in the spinal cord horn. ... In neuroscience, granule cells are tiny cells found within the granular layer of the cerebellum. ... Illustration of the major elements in a prototypical synapse. ... Neuropil is the feltwork of unmyelinated neuronal processes (axonal and dendritic) within the gray matter of the central nervous system Traditionally, when pathologists looked at brain tissue they concentrated on neurons (the active functioning cells of the brain), glial cells and axons (especially in white matter, which is mostly composed... In a synapse, a bouton (or synaptic button, or presynaptic button) is a protuberance at the pre-synaptic nerve terminal where two axons connect with each other. ... In a neuron, synaptic vesicles, also called neurotransmitter vesicles, store the various neurotransmitters that are released during calcium-regulated exocytosis at the presynaptic terminal into the synaptic cleft of a synapse. ... A neuromuscular junction is the junction of the axon terminal of a motoneuron with the motor end plate, the highly-excitable region of muscle fiber plasma membrane responsible for initiation of action potentials across the muscles surface. ... An electrical synapse is a mechanical and electrically conductive link between two abutting neurons that is formed at a narrow gap between the pre- and postsynaptic cells known as a gap junction. ...

Sensory receptors: Free nerve ending, Meissner's corpuscle, Merkel nerve ending, Muscle spindle, Pacinian corpuscle, Ruffini ending, Olfactory receptor neuron, Photoreceptor, Hair cell, Taste bud In a sensory system, a sensory receptor is a structure that recognizes a stimulus in the internal or external environment of an organism. ... NERVE ENDINGS SUCK PENIS!!! ... Meissners corpuscles (discovered by the anatomist Georg Meissner (1829-1903) are a type of mechanoreceptor and more specifically, a tactile corpuscle(corpusculum tactus). ... Merkel nerve endings are mechanoreceptors found in the skin and mucosa of vertebrates that provide touch information to the brain. ... A muscle spindle is a specialized muscle structure innervated by both sensory and motor neuron axons. ... A Pacinian corpuscle is a structure that functions as a mechanoreceptor. ... Ruffini Endings are one of the four main cutaneous mechanoreceptors. ... An olfactory receptor neuron, also called an olfactory sensory neuron, is the primary transduction cell for olfaction in the olfactory system. ... A photoreceptor is a specialized form of cell (specifically, neuron) that is capable of phototransduction. ... Hair cells are the sensory cells of both the auditory system and the vestibular system in all vertebrates. ... Taste buds are small structures on the upper surface of the tongue, soft palate, and epiglottis that provide information about the taste of food being eaten. ...

Glial cells: astrocyte, ependymal cells, microglia, radial glia This article or section does not cite its references or sources. ... Astrocytes, also known as astroglia, are characteristic star-shaped glial cells in the brain. ... It has been suggested that this article or section be merged with Ependyma. ... Microglia are a type of glial cell that act as the immune cells of the Central nervous system (CNS). ... Radial glial cells are a pivotal cell type in the developing CNS involved in key developmental processes, ranging from patterning and neuronal migration to their newly described role as precursors during neurogenesis. ...

Myelination (white matter): Schwann cell, oligodendrocyte, nodes of Ranvier, internode, Schmidt-Lanterman incisures, neurolemma In neuroscience, myelin is an electrically insulating phospholipid layer that surrounds the axons of many neurons. ... White matter is one of the two main solid components of the central nervous system. ... Schwann cells are a variety of neuroglia that wrap around axons in the peripheral nervous system, forming the myelin sheath. ... Oligodendrocytes (from Greek literally meaning few tree cells), or oligodendroglia (Greek, few tree glue)[1], are a variety of neuroglia. ... This article is about Anatomy, for the musical group see Nodes of Ranvier (band) Nodes of Ranvier are regularly spaced gaps in the myelin sheath around an axon or nerve fiber. ... The portion of nerve fiber between two Nodes of Ranvier is called an internodal segment (or internode). ... Oblique clefts may be seen in the medullary sheath, subdividing it into irregular portions, which are termed Schmidt-Lanterman incisures (or clefts of schmidt-lanterman, segments of Lantermann, medullary segments. ... Neurolemma (spelled also neurolema, neurilemma and neurilema, and used interchangeably with epineurium) is the insulating myelin layer that surrounds an individual peripheral nerve fiber. ...

closely related Connective tissue: epineurium, perineurium, endoneurium, nerve fascicle, meninges In the human body there are four types of tissue: (1) Epithelial, (2) Connective, (3) Muscle, and (4) Nervous Tissue. ... Neurolemma (spelled also neurolema, neurilemma and neurilema, and used interchangeably with epineurium) is the insulating myelin layer that surrounds an individual peripheral nerve fiber. ... In a nerve fiber, the tubular sheath of the funiculi, perineurium, is a fine, smooth, transparent membrane, which may be easily separated, in the form of a tube, from the fibers it encloses; in structure it is made up of connective tissue, which has a distinctly lamellar arrangement. ... The nerve fibers are held together and supported within the funiculus by delicate connective tissue, called the endoneurium. ... A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or nerve fascicles, which are bound together in a common... The meninges (singular meninx) are the system of membranes that envelop the central nervous system. ...

  Results from FactBites:
Dorlands Medical Dictionary (3593 words)
Nissl bodies large granular basophilic bodies found in the cytoplasm of neurons, composed of rough endoplasmic reticulum and free polyribosomes; called also chromophilous b's, chromophilic or chromatic granules, tigroid bodies or substance, and Nissl's granules or substance.
a cytoplasmic body of varying appearance, structure, and function closely associated with the nucleus, kinetoplast, and basal body in certain parasitic flagellate protozoa; it is usually connected to the basal body by a fibril or thread, which together are known as the parabasal apparatus.
an ovoid body found in the adventitia of the upper part of the superior bulb of the internal jugular vein; its structure and presumably its function are similar to those of the glomus caroticum (carotid body).
Franz Nissl (www.whonamedit.com) (1081 words)
Franz Nissl was born in Frankenthal in the Bavarian Palatinate, the son of Theodor Nissl and Maria Haas.
Nissl employed alcohol as a fixative and developed a staining technique which he improved upon in such a way that he was able to demonstrate a number of previously unknown constituents of nerve cells.
Outwardly Nissl was a gnome of a man, with bad posture and a tilting of the head due perhaps to an effort to conceal the large bitemark on the left side of his face.
  More results at FactBites »



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