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Encyclopedia > Nifedipine

Nifedipine chemical structure
Nifedipine Image File history File links Nifedipine. ...

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)
-3,5-pyridinedicarboxylic acid, dimethyl ester

IUPAC name
CAS number
21829-25-4
ATC code
C08CA05
Chemical formula C17H18N2O6
Molecular weight 346.337
Bioavailability 45-56%
Metabolism Gastrointestinal
Hepatic
Elimination half-life 6-10 hours
Excretion Renal: >50%
Biliary: 5-15%
Pregnancy category C: (USA)
Legal status
Routes of administration Oral

Nifedipine (brand name Adalat and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are in angina pectoris (especially Prinzmetal angina) and hypertension, although a large number of other uses have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer patients. IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless Atomic mass 15. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The gastrointestinal tract or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and expels the remaining waste. ... The liver is one of the largest internal organs of the human body. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... The hour (symbol: h) is a unit of time. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... Bile (or gall) is a bitter, greenish-yellow alkaline fluid secreted by the liver of most vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... Sagittal section of nose mouth, pharynx, and larynx. ... Calcium channel blockers are a class of drugs with effects on the muscle of the heart and the muscles of the rest of the body. ... Prinzmetals angina, also known as variant angina or angina inversa, is a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. ... For other forms of hypertension see hypertension (disambiguation) Hypertension or high blood pressure is a medical condition wherein the blood pressure is chronically elevated. ... In medicine, Raynauds phenomenon is discoloration of the fingers or toes due to emotion or cold in a characteristic pattern in time: white, blue and red. ... Premature birth is defined medically as a birth occurring earlier than 37 weeks. ... The esophagus (also spelled oesophagus/œsophagus), or gullet is the muscular tube in vertebrates through which ingested food passes from the mouth area to the stomach. ... When normal cells are damaged beyond repair, they are eliminated by apoptosis. ...


Nifedipine lowers the blood pressure rapidly, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. Tachycardia (fast heart rate) may occur as a reaction. These problems are much less frequent in the sustain-release preparations of nifedipine (such as Adalat OROS). Tachycardia is an abnormally rapid beating of the heart, defined as a resting heart rate of over 100 beats per minute. ...


See also

  • Nifedipine - rxlist.com
  • Nifedipine - medlineplus.org


Calcium channel blockers edit
Class I edit

{Verapamil} Calcium channel blockers are a class of drugs with effects on the muscle of the heart and the muscles of the rest of the body. ... Verapamil (brand names: Isoptin®, Verelan®, Calan®) is a medical drug that acts as an L-type calcium channel blocker. ...

Class II edit

{Amlodipine} {Felodipine} {Nicardipine} {Nifedipine} {Nisoldipine} {Nimodipine} Amlodipine (as besylate or malleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. ... Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). ... Nimodipine (marketed by Bayer as Nimotop®) is a dihydropyridine calcium channel blocker originally developed for the treatment of high blood pressure. ...

Class III edit

{Diltiazem} Diltiazem is a member of the group of drugs known as calcium channel blockers, used in the treatment of hypertension or angina. ...


 
 

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