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Encyclopedia > Neurotoxins

A neurotoxin is a toxin that acts specifically on nerve cells, or neurons, usually by interacting with membrane proteins and ion channels. Many of the venoms and other toxins that organisms use in defense against vertebrates are neurotoxins. A common effect is paralysis, which sets in extremely rapidly. Examples of neurotoxins include tetrodotoxin and components of the venom in bees, scorpions and spiders.


Toxins taken in from the environment are described as exogenous and include gases (eg carbon monoxide), metals (such as mercury), liquids (ethanol) and an endless list of solids. When exogenous toxins are taken in, the effect on neurons is largely dependent on dosage. Thus ethanol (alcohol) is inebriating in low doses, only producing mild neurotoxicity. Prolonged exposure to "safe" alcohol levels slowly weakens and kills neurons.


Neurotoxicity also occurs from substances produced within the body - endogenous neurotoxins. A prime example of a neurotoxin in the brain is glutamate, which is paradoxically also a primary neurotransmitter. When the glutamate concentration around a neuron reaches a critical point the neuron kills itself by a process called apoptosis. This whole process is called excitotoxicity, so named because glutamate normally acts as an excitatory neurotransmitter at lower levels.


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  Results from FactBites:
 
YOJOE.COM | Neurotoxin (164 words)
Neurotoxin was released as part of the twentieth series (2004), carded in a two-pack with Razor Trooper as part of the Valor vs Venom line.
Both Neurotoxin and Sand Scorpion (v2) came with two fl and brown claws, a brown scorpion (that doubled as a backpack), and a fl rifle.
The same mold and paint scheme was used for Neurotoxin and Sand Scorpion (v2).
Seeing a neurotoxin's deadly grip (979 words)
Botulinum neurotoxin hijacks synaptic vesicle recycling at neuromuscular junctions.
Botulinum neurotoxins are among the most deadly natural toxins in the world.
The toxins principally affect muscle-controlling motor neurons activated by the neurotransmitter acetylcholine.
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