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Encyclopedia > Neuraminidase inhibitor

Neuraminidase inhibitors are a class of antiviral drugs, whose mode of action relies on blocking the function of viral neuraminidase protein, thus preventing the virus from budding from the host cell. Antiviral drugs are a class of medication used specifically for treating viral infections. ... Neuraminidase ribbon diagram Neuraminidase is an antigenic glycoprotein enzyme (EC 3. ... General Biological Meaning Budding is a type of asexual reproduction. ...


Oseltamivir and Zanamivir belong to this class. Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. ... Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ...


Unlike the M2 inhibitors, which work only against the influenza A, neuraminidase inhibitors act against both influenza A and B. The M2 protein is a proton-selective ion channel protein, integral in the cell membrane of the influenza A virus. ...


See also:

  • This flash animation shows the mode of action of oseltamivir (Tamiflu®)
  • Replication of influenza virus

  Results from FactBites:
 
Flu Wiki - Consequences - Neuraminidase Inhibitors (1132 words)
Neuraminidase inhibitors must be taken within 48 hours—preferably within 36 hours—of the onset of flu symptoms.
The structure of the neuraminidase inhibitor in Tamiflu is not as good a fit as the structure of Relenza and seems more prone to allowing resistance to develop.
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections.
Zanamivir - Wikipedia, the free encyclopedia (826 words)
Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed.
Whilst zanamivir proved to be a potent and effective inhibitor of influenza neuraminidase and inhibitor of influenza virus replication in vitro and in vivo, this didn't necessarily translate into a successful clinical treatment for influenza.
And although zanamivir was the first neuraminidase inhibitor to the market, it had only a few months lead over the second entrant, oseltamivir (Tamiflu), with an oral formulation much preferred by patients.
  More results at FactBites »

 
 

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