Neuraminidase inhibitors are a class of antiviral drugs, whose mode of action relies on blocking the function of viral neuraminidase protein, thus preventing the virus from budding from the host cell. Antiviral drugs are a class of medication used specifically for treating viral infections. ... Neuraminidase ribbon diagram Neuraminidase is an antigenic glycoprotein enzyme (EC 3. ... General Biological Meaning Budding is a type of asexual reproduction. ...
Oseltamivir and Zanamivir belong to this class. Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. ... Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ...
Unlike the M2 inhibitors, which work only against the influenza A, neuraminidase inhibitors act against both influenza A and B. The M2 protein is a proton-selective ion channel protein, integral in the cell membrane of the influenza A virus. ...
This flash animation shows the mode of action of oseltamivir (Tamiflu®)
Zanamivir is a neuraminidaseinhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidaseinhibitor commercially developed.
Whilst zanamivir proved to be a potent and effective inhibitor of influenza neuraminidase and inhibitor of influenza virus replication in vitro and in vivo, this didn't necessarily translate into a successful clinical treatment for influenza.
And although zanamivir was the first neuraminidaseinhibitor to the market, it had only a few months lead over the second entrant, oseltamivir (Tamiflu), with an oral formulation much preferred by patients.
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