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Encyclopedia > Myocardial disarray

Myocardial disarray, also known as myocyte disarray, is a term to describe the loss of the normal parallel alignment of myocytes (the muscle cells of the heart). Instead, the myocytes usually form circles around foci of connective tissue. Myocardial disarray is associated with myocardial fibrosis (the replacement of the myocytes with non-contractile scar tissue).


Myocardial disarray can be seen in a number of disease states, including:

The common factor amongst all these diseases is that they all cause varying degrees of remodelling (myocardial fibrosis) of the ventricles.


  Results from FactBites:
 
Myocardial disarray: an architectural disorganization linked with adrenergic stress? (337 words)
BACKGROUND: Myocardial disarray is a structural abnormality found in specific zones of the normal heart.
The incidence of "pathological" myocardial disarray in humans is still not known.
The frequency and presence of myocardial disarray were recorded and correlated to heart weight, extent of myocardial fibrosis, and contraction band necrosis (CBN).
A Physician's Guide to the Treatment of Hypertrophic Cardiomyopathy (4923 words)
Specifically, the increased myocardial contractility, and higher heart rate (with a shorter diastolic filling period) will worsen the outflow tract obstruction, increase the severity of mitral regurgitation, increase myocardial oxygen demand, and worsen diastolic filling.
As with patients who develop a spontaneous myocardial infarction, there may be a potential for ventricular arrhythmias and perhaps even unfavorable ventricular remodeling.
The need for permanent pacemaker has been as high as 30 percent, as the myocardial infarction is in the region of the bundle of HIS.
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