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Encyclopedia > Multiple endocrine neoplasia type 2

Multiple endocrine neoplasia type 2 is part of a group of disorders that affect the endocrine system. These disorders greatly increase the risk of developing multiple cancerous and noncancerous tumors in glands such as the thyroid, parathyroid, and adrenals. Multiple endocrine neoplasia occurs when tumors are found in at least two endocrine glands. Tumors can also develop in organs and tissues other than endocrine glands. If the tumors become cancerous, some cases can be life-threatening. The disorder effects 1 in 30,000 people. Major endocrine glands. ... When normal cells are damaged beyond repair, they are eliminated by apoptosis. ... Tumor (American English) or tumour (British English) originally means swelling, and is sometimes still used with that meaning. ... Categories: Anatomy stubs | Endocrine system ... Grays Fig. ...


Although many different types of hormone-producing tumors are associated with multiple endocrine neoplasia, the most common sign of multiple endocrine neoplasia type 2 is a form of thyroid cancer called medullary thyroid carcinoma. This tumor secretes an inactive hormone called calcitonin. Many people with this disorder also develop pheochromocytoma, which is a tumor of the adrenal glands (located above each kidney) that can cause dangerously high blood pressure. In addition, overactivity of the parathyroid gland (hyperparathyroidism) occurs in some cases of multiple endocrine neoplasia type 2. Hyperparathyroidism disrupts the normal balance of calcium in the blood, which can lead to kidney stones, thinning of bones, weakness, and fatigue. Calcitonin is a a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobranchial body. ... A pheochromocytoma (also phaeochromocytoma, English spelling) is a tumor of the medulla of the adrenal glands originating in the chromaffin cells, which secretes excessive amounts of catecholamines, usually epinephrine and norepinephrine. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... Blood pressure is the pressure exerted by the blood on the walls of the blood vessels. ... Hyperparathyroidism is overactivity of the parathyroid glands resulting in excess production of parathyroid hormone (PTH). ... General Name, Symbol, Number calcium, Ca, 20 Chemical series alkaline earth metals Group, Period, Block 2, 4, s Appearance silvery white Atomic mass 40. ... Kidney stones are solid accretions (crystals) of dissolved minerals in urine found inside the kidneys or ureters. ... Grays illustration of a human femur, a typically recognized bone. ...


The two major types of multiple endocrine neoplasia type 1 and type 2, are often confused because they have similar names. These types are distinguished by the genes involved, the hormones that are affected, and their characteristic signs and symptoms. They are also very different in their options for cancer prevention and treatment. Multiple endocrine neoplasia type 2 can be further divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC). These subtypes differ in their characteristic signs and symptoms and risk of specific tumors, but are relatively consistent within any one family. Multiple endocrine neoplasia type 1 is part of a group of disorders that affect the endocrine system. ...


Mutations in the RET gene cause multiple endocrine neoplasia type 2. The protein produced by the RET gene normally plays an important role in signaling cells to respond to their environment, for example by dividing or maturing. Mutations in this gene cause an overactivation of the protein's signaling function, which can lead to an overgrowth of cells and the formation of tumors characteristic of multiple endocrine neoplasia type 2. This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... This article or section does not cite its references or sources. ...


Most cases of multiple endocrine neoplasia type 2 are inherited in an autosomal dominant pattern, which means affected people may have affected siblings and relatives in successive generations (such as parents and children). An affected person usually has one parent with the condition. Some cases, however, result from new mutations in the RET gene. These cases occur in people with no history of the disorder in their family. An autosomal dominant gene is an abnormal gene on one of the autosomal (non-sex determining) chromosomes. ...


This article incorporates public domain text from The U.S. National Library of Medicine


 
 

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