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Encyclopedia > Morphinan

Morphinan is the base chemical structures of a subgroup of opioids. An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. ...


  Results from FactBites:
Medscape MEDLINE search: Morphinans (1064 words)
A novel series of morphinans were synthesized, and their binding affinity at and functional selectivity for micro, delta, and kappa opioid receptors were evaluated.
Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques.
PURPOSE: A series of morphine and morphinan derivatives were chromatographed on a column containing immobilized cellular membranes from a cell line expressing the alpha 3 beta 4 neuronal nicotinic acetylcholine receptor (alpha 3 beta 4 nAChR).
Morphinan derivatives and pharmaceutical use thereof - Patent 6177438 (4570 words)
A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, ##STR1## and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described.
The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective.kappa.-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive.
A pharmaceutical composition comprising a pharmaceutically effective amount of the morphinan derivative according to claim 1, or its pharmaceutically acceptable acid addition salt, and a pharmaceutically acceptable carrier.
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