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Encyclopedia > Mitosis
Mitosis divides genetic information during cell division.
Mitosis divides genetic information during cell division.

Mitosis is the process by which a cell duplicates its genetic information (DNA), in order to generate two, identical, daughter cells. It is generally followed immediately by cytokinesis which divides the cytoplasm and cell membrane. This results in two identical daughter cells with a roughly equal distribution of organelles and other cellular components. Mitosis and cytokinesis together define the mitotic (M) phase of the cell cycle, the division of the mother cell into two daughter cells, each with the genetic equivalent of the parent cell. Image File history File links Major_events_in_mitosis. ... Image File history File links Major_events_in_mitosis. ... A cell that has almost completed cytokinesis. ... Organelles. ... Look up cell membrane in Wiktionary, the free dictionary. ... Schematic of typical animal cell, showing subcellular components. ... The cell cycle, or cell-division cycle, is the series of events that take place in a eukaryotic cell leading to its replication. ... This does not adequately cite its references or sources. ...


Mitosis occurs exclusively in eukaryotic cells, but occurs in different ways in different species. For example, animals undergo an "open" mitosis, where the nuclear envelope breaks down before the chromosomes separate, while yeast such as Saccharomyces cerevisiae and fungi such as Aspergillus nidulans undergo a "closed" mitosis, where chromosomes divide within an intact cell nucleus.[1] In multicellular organisms, the somatic cells undergo mitosis, while germ cells — cells destined to become sperm in males or ova in females — divide by a related process called meiosis. Prokaryotic cells, which lack a nucleus, divide by a process called binary fission. Kingdoms Animalia - Animals Fungi Plantae - Plants Chromalveolata Protista Alternative phylogeny Unikonta Opisthokonta Metazoa Choanozoa Eumycota Amoebozoa Bikonta Apusozoa Cabozoa Rhizaria Excavata Corticata Archaeplastida Chromalveolata Animals, plants, fungi, and protists are eukaryotes (IPA: ), organisms whose cells are organized into complex structures by internal membranes and a cytoskeleton. ... For other uses, see Animal (disambiguation). ... The nuclear envelope (also known as the perinuclear envelope, nuclear membrane, nucleolemma or karyotheca) is the double membrane of the nucleus that encloses genetic material in eukaryotic cells. ... Typical divisions Ascomycota (sac fungi) Saccharomycotina (true yeasts) Taphrinomycotina Schizosaccharomycetes (fission yeasts) Basidiomycota (club fungi) Urediniomycetes Sporidiales Yeasts are a growth form of eukaryotic microorganisms classified in the kingdom Fungi, with approximately 1,500 species described. ... Binomial name Meyen ex E.C. Hansen Saccharomyces cerevisiae is a species of budding yeast. ... Divisions Chytridiomycota Zygomycota Ascomycota Basidiomycota The Fungi (singular: fungus) are a large group of organisms ranked as a kingdom within the Domain Eukaryota. ... Binomial name Aspergillus nidulans G Winter 1884 Synonyms Emericella nidulans Aspergillus nidulans (sometimes found like Emericella nidulans) is one of many species of filamentous fungi in the phylum Ascomycota. ... HeLa cells stained for DNA with the Blue Hoechst dye. ... This article does not cite any references or sources. ... A germ cell is part of the germline and is involved in the reproduction of organisms. ... For other uses, see Sperm (disambiguation). ... A human ovum Sperm cells attempting to fertilize an ovum An ovum (plural ova) is a haploid female reproductive cell or gamete. ... Not to be confused with miosis. ... Prokaryotes (pro-KAR-ee-oht) (from Old Greek pro- before + karyon nut or kernel, referring to the cell nucleus, + suffix -otos, pl. ... Binary fission Binary fission is the form of asexual reproduction in single-celled organisms by which one cell divides into two cells of the same size, used by most prokaryotes. ...


The process of mitosis is complex and highly regulated. The sequence of events is divided into phases, corresponding to the completion of one set of activities and the start of the next. These stages are prophase, prometaphase, metaphase, anaphase and telophase. During the process of mitosis the pairs of chromosomes condense and attach to fibers that pull the sister chromatids to opposite sides of the cell. The cell then divides in cytokinesis, to produce two identical daughter cells. This article is about the biological chromosome. ... Sister chromatids are identical copies of a chromosome. ... A cell that has almost completed cytokinesis. ...


Because cytokinesis usually occurs in conjunction with mitosis, "mitosis" is often used interchangeably with "mitotic phase". However, there are many cells where mitosis and cytokinesis occur separately, forming single cells with multiple nuclei. This occurs most notably among the fungi and slime moulds, but is found in various different groups. Even in animals, cytokinesis and mitosis may occur independently, for instance during certain stages of fruit fly embryonic development.[2] Errors in mitosis can either kill a cell through apoptosis or cause mutations that may lead to cancer. Subkingdom/Phyla Chytridiomycota Blastocladiomycota Neocallimastigomycota Glomeromycota Zygomycota Dikarya (inc. ... Typical orders Protostelia    Protosteliida Myxogastria    Liceida    Echinosteliida    Trichiida    Stemonitida    Physarida Dictyostelia    Dictyosteliida Slime mould (or slime mold) is a broad term often referring to roughly 6 groups of Eukaryotes. ... Binomial name Meigen, 1830[1] Drosophila melanogaster (from the Greek for black-bellied dew-lover) is a two-winged insect that belongs to the Diptera, the order of the flies. ... A section of mouse liver showing an apoptotic cell indicated by an arrow Apoptosis (pronounced apo tō sis) is a process of suicide by a cell in a multicellular organism. ... It has been suggested that mutant be merged into this article or section. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...

A cell in late metaphase. All chromosomes (blue) but one have arrived at the metaphase plate.

Contents

Image File history File links An image of a newt lung cell stained with flourescent dyes undergoing mitosis, specifically during early anaphase. ... Image File history File links An image of a newt lung cell stained with flourescent dyes undergoing mitosis, specifically during early anaphase. ... An image of a newt lung cell stained with fluorescent dyes during metaphase. ...

Overview

The primary result of mitosis is the division of the parent cell's genome into two daughter cells. The genome is composed of a number of chromosomes, complexes of tightly-coiled DNA that contain genetic information vital for proper cell function. Because each resultant daughter cell should be genetically identical to the parent cell, the parent cell must make a copy of each chromosome before mitosis. This occurs during S phase, in interphase, the period that precedes the mitotic phase in the cell cycle where preparation for mitosis occurs.[3] Figure 1: A representation of a condensed eukaryotic chromosome, as seen during cell division. ... The structure of part of a DNA double helix Deoxyribonucleic acid, or DNA, is a nucleic acid molecule that contains the genetic instructions used in the development and functioning of all known living organisms. ... part of a DNA sequence A DNA sequence (sometimes genetic sequence) is a succession of letters representing the primary structure of a real or hypothetical DNA molecule or strand, The possible letters are A, C, G, and T, representing the four nucleotide subunits of a DNA strand (adenine, cytosine, guanine... Molecular cloning refers to the procedure of isolating a defined DNA sequence and obtaining multiple copies of it in vivo. ... This article does not cite any references or sources. ...


Each new chromosome now contains two identical copies of itself, called sister chromatids, attached together in a specialized region of the chromosome known as the centromere. Each sister chromatid is not considered a chromosome in itself, and a chromosome does not always contain two sister chromatids. A chromatid forms one part of a chromosome after it has coalesced for the process of mitosis or meiosis. ... The centromere is a region of chromosomes with a special sequence and structure. ...


In most eukaryotes, the nuclear envelope that separates the DNA from the cytoplasm disassembles. The chromosomes align themselves in a line spanning the cell. Microtubules, essentially miniature strings, splay out from opposite ends of the cell and shorten, pulling apart the sister chromatids of each chromosome.[4] As a matter of convention, each sister chromatid is now considered a chromosome, so they are renamed to sister chromosomes. As the cell elongates, corresponding sister chromosomes are pulled toward opposite ends. A new nuclear envelope forms around the separated sister chromosomes. Kingdoms Eukaryotes are organisms with complex cells, in which the genetic material is organized into membrane-bound nuclei. ... The nuclear envelope (also known as the perinuclear envelope, nuclear membrane, nucleolemma or karyotheca) is the double membrane of the nucleus that encloses genetic material in eukaryotic cells. ... Organelles. ... Microtubules are one of the components of the cytoskeleton. ...


As mitosis completes cytokinesis is well underway. In animal cells, the cell pinches inward where the imaginary line used to be, (the pinching of the cell membrane to form the two daughter cells is called cleavage furrow) separating the two developing nuclei. In plant cells, the daughter cells will construct a new dividing cell wall between each other. Eventually, the mother cell will be split in half, giving rise to two daughter cells, each with an equivalent and complete copy of the original genome. A three-dimensional diagram of the animal cell, including its organelles. ... Plant cell structure Plant cells are quite different from the cells of the other eukaryotic kingdoms organisms. ...


Prokaryotic cells undergo a process similar to mitosis called binary fission. However, prokaryotes cannot be properly said to undergo mitosis because they lack a nucleus and only have a single chromosome with no centromere.[5]


Phases

Interphase

The cell cycle
The cell cycle


The mitotic phase is a relatively short period of the cell cycle. It alternates with the much longer interphase, where the cell prepares itself for cell division. Interphase is divided into three phases, G1 (first gap), S (synthesis), and G2 (second gap). During all three phases, the cell grows by producing proteins and cytoplasmic organelles. However, chromosomes are replicated only during the S phase. Thus, a cell grows (G1), continues to grow as it duplicates its chromosomes (S), grows more and prepares for mitosis (G2), and divides (M).[3] Image File history File links from meta File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ... Image File history File links from meta File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ... The cell cycle, or cell-division cycle, is the series of events that take place in a eukaryotic cell leading to its replication. ... This article does not cite any references or sources. ... DNA replication. ...


Preprophase

Main article: Preprophase

In plant cells only, prophase is preceded by a pre-prophase stage. In highly vacuolated plant cells, the nucleus has to migrate into the center of the cell before mitosis can begin. This is achieved through the formation of a phragmosome, a transverse sheet of cytoplasm that bisects the cell along the future plane of cell division. In addition to phragmosome formation, preprophase is characterized by the formation of a ring of microtubules and actin filaments (called preprophase band) underneath the plasmamembrane around the equatorial plane of the future mitotic spindle and predicting the position of cell plate fusion during telophase. The cells of higher plants (such as the flowering plants) lack centrioles. Instead, spindle microtubules aggregate on the surface of the nuclear envelope during prophase. The preprophase band disappears during nuclear envelope disassembly and spindle formation in prometaphase.[6] Microtubule dynamics during preprophase and prophase in plant cell mitosis, modified from Donukshe et al. ... Phragmosome formation in a highly vacuolated plant cell. ... The preprophase band predicts the cell division plane: 1) Preprophase band formation during preprophase. ... A cell during telophase that has almost completed cytokinesis. ...


Prophase

Prophase: The two round objects above the nucleus are the centrosomes. Note the condensed chromatin.
Main article: Prophase

Normally, the genetic material in the nucleus is in a loosely bundled coil called chromatin. At the onset of prophase, chromatin condenses together into a highly ordered structure called a chromosome. Since the genetic material has already been duplicated earlier in S phase, the replicated chromosomes have two sister chromatids, bound together at the centromere by the cohesion complex. Chromosomes are visible at high magnification through a light microscope. Image File history File links This is step II cut out from Image:Gray2. ... Newt lung cell in Prophase, with the mitotic spindles stained green and the cell nucleus and chromatin stained blue. ... Chromatin is the complex of DNA and protein found inside the nuclei of eukaryotic cells. ... The centromere is a region of chromosomes with a special sequence and structure. ...


Close to the nucleus are two centrosomes. Each centrosome, which was replicated earlier independent of mitosis, acts as a coordinating center for the cell's microtubules. The two centrosomes nucleate microtubules (which may be thought of as cellular ropes or poles) by polymerizing soluble tubulin present in the cytoplasm. Molecular motor proteins create repulsive forces that will push the centrosomes to opposite side of the nucleus. The centrosomes are only present in animals. In plants the microtubules form independently. The centrosome is the main microtubule organizing center (MTOC) of the cell as well as a regulator of cell-cycle progression. ... Microtubules are one of the components of the cytoskeleton. ... Tubulin is the protein which makes up microtubules. ... Molecular motors are biological nanomachines and are the essential agents of movement in living organisms. ...


Some centrosomes contain a pair of centrioles that may help organize microtubule assembly, but they are not essential to formation of the mitotic spindle.[7] A centriole is a barrel shaped organelle[1] found in most eukaryotic cells, though absent in higher plants and fungi. ...

Prometaphase

Prometaphase: The nuclear membrane has degraded, and microtubules have invaded the nuclear space. These microtubules can attach to kinetochores or they can interact with opposing microtubules.
Prometaphase: The nuclear membrane has degraded, and microtubules have invaded the nuclear space. These microtubules can attach to kinetochores or they can interact with opposing microtubules.
Main article: Prometaphase

The nuclear envelope disassembles and microtubules invade the nuclear space. This is called open mitosis, and it occurs in most multicellular organisms. Fungi and some protists, such as algae or trichomonads, undergo a variation called closed mitosis where the spindle forms inside the nucleus or its microtubules are able to penetrate an intact nuclear envelope.[8][9] Image File history File links This is step III cut out from Image:Gray2. ... In early prometaphase, the nuclear membrane has just degraded, allowing the microtubules to quickly interact with the kinetochores on the chromosomes, which have just condensed. ... Typical phyla Chromalveolata Chromista Heterokontophyta Haptophyta Cryptophyta (cryptomonads) Alveolata Dinoflagellata Apicomplexa Ciliophora (ciliates) Cabozoa Excavata Euglenozoa Percolozoa Metamonada Rhizaria Radiolaria Foraminifera Cercozoa Archaeplastida (in part) Rhodophyta (red algae) Glaucophyta (basal archaeplastids) Amoebozoa Choanozoa Many others; classification varies Protists (IPA: (RP); (GenAm)), Greek protiston -a meaning the (most) first of all... A seaweed (Laurencia) up close: the branches are multicellular and only about 1 mm thick. ... families Calonymphidae Cochlosomatidae Devescovinidae Monocercomonadidae Trichomonadidae The trichomonads are an order of anaerobic protists, included with the parabasalids. ...


Each chromosome forms two kinetochores at the centromere, one attached at each chromatid. A kinetochore is a complex protein structure that is analogous to a ring for the microtubule hook; it is the point where microtubules attach themselves to the chromosome.[10] Although the kinetochore structure and function are not fully understood, it is known that it contains some form of molecular motor.[11] When a microtubule connects with the kinetochore, the motor activates, using energy from ATP to "crawl" up the tube toward the originating centrosome. This motor activity, coupled with polymerisation and depolymerisation of microtubules, provides the pulling force necessary to later separate the chromosome's two chromatids.[11] The kinetochore is the protein structure in eukaryotes which assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis. ... This is a list of gene families or gene complexes, that is sets of genes which occur across a number of different species which often serve similar biological functions. ... Adenosine 5-triphosphate (ATP) is a multifunctional nucleotide that is most important as a molecular currency of intracellular energy transfer. ...


When the spindle grows to sufficient length, kinetochore microtubules begin searching for kinetochores to attach to. A number of nonkinetochore microtubules find and interact with corresponding nonkinetochore microtubules from the opposite centrosome to form the mitotic spindle.[12] Prometaphase is sometimes considered part of prophase.

Metaphase

Metaphase: The chromosomes have aligned at the metaphase plate.
Main article: Metaphase

As microtubules find and attach to kinetochores in prometaphase, the centromeres of the chromosomes convene along the metaphase plate or equatorial plane, an imaginary line that is equidistant from the two centrosome poles.[12] This even alignment is due to the counterbalance of the pulling powers generated by the opposing kinetochores, analogous to a tug-of-war between equally strong people. In certain types of cells, chromosomes do not line up at the metaphase plate and instead move back and forth between the poles randomly, only roughly lining up along the midline. Metaphase comes from the Greek μετα meaning "after." Image File history File links This is step IV cut out from Image:Gray2. ... An image of a newt lung cell stained with fluorescent dyes during metaphase. ...


Because proper chromosome separation requires that every kinetochore be attached to a bundle of microtubules (spindle fibers) , it is thought that unattached kinetochores generate a signal to prevent premature progression to anaphase[1] without all chromosomes being aligned. The signal creates the mitotic spindle checkpoint.[13] Newt lung cell during late anaphase. ... The spindle checkpoint blocks entry into anaphase until all chromosomes are properly attached to the mitotic spindle. ...

Anaphase

Early anaphase: Kinetochore microtubules shorten
Early anaphase: Kinetochore microtubules shorten
Main article: Anaphase

When every kinetochore is attached to a cluster of microtubules and the chromosomes have lined up along the metaphase plate, the cell proceeds to anaphase (from the Greek ανα meaning “up,” “against,” “back,” or “re-”). Image File history File links This is step V cut out from Image:Gray2. ... Newt lung cell during late anaphase. ...


Two events then occur; First, the proteins that bind sister chromatids together are cleaved, allowing them to separate. These sister chromatids turned sister chromosomes are pulled apart by shortening kinetochore microtubules and toward the respective centrosomes to which they are attached. Next, the nonkinetochore microtubules elongate, pushing the centrosomes (and the set of chromosomes to which they are attached) apart to opposite ends of the cell.


These two stages are sometimes called early and late anaphase. Early anaphase is usually defined as the separation of the sister chromatids, while late anaphase is the elongation of the microtubules and the microtubules being pulled farther apart. At the end of anaphase, the cell has succeeded in separating identical copies of the genetic material into two distinct populations.

Telophase

Telophase: The decondensing chromosomes are surrounded by nuclear membranes. Note cytokinesis has already begun, the pinching is known as the cleavage furrow.
Telophase: The decondensing chromosomes are surrounded by nuclear membranes. Note cytokinesis has already begun, the pinching is known as the cleavage furrow.
Main article: Telophase

Telophase (from the Greek τελος meaning "end") is a reversal of prophase and prometaphase events. It "cleans up" the after effects of mitosis. At telophase, the nonkinetochore microtubules continue to lengthen, elongating the cell even more. Corresponding sister chromosomes attach at opposite ends of the cell. A new nuclear envelope, using fragments of the parent cell's nuclear membrane, forms around each set of separated sister chromosomes. Both sets of chromosomes, now surrounded by new nuclei, unfold back into chromatin. Mitosis is complete, but cell division is not yet complete. Image File history File links This is step VII cut out from Image:Gray2. ... A cell during telophase that has almost completed cytokinesis. ...

Cytokinesis

Main article: Cytokinesis

Cytokinesis is often mistakenly thought to be the final part of telophase, however cytokinesis is a separate process that begins at the same time as telophase. Cytokinesis is technically not even a phase of mitosis, but rather a separate process, necessary for completing cell division. In animal cells, a cleavage furrow (pinch) containing a contractile ring develops where the metaphase plate used to be, pinching off the separated nuclei.[14] In both animal and plant cells, cell division is also driven by vesicles derived from the Golgi apparatus, which move along microtubules to the middle of the cell. [15] In plants this structure coalesces into a cell plate at the center of the phragmoplast and develops into a cell wall, separating the two nuclei. The phragmoplast is a microtubule structure typical for higher plants, whereas some green algae use a phycoplast microtubule array during cytokinesis.[16] Each daughter cell has a complete copy of the genome of its parent cell. The end of cytokinesis marks the end of the M-phase. A cell that has almost completed cytokinesis. ... In cell biology, the cleavage furrow is the indentation that begins the process of cleavage, by which animal cells undergo cytokinesis. ... Micrograph of Golgi apparatus, visible as a stack of semicircular black rings near the bottom. ... A phragmoplast is the center region of the mitotic spindle of a cell during the telophase portion of mitosis. ... Schematic representation of types of cytokinesis in the green algae: 1) Phycoplast formation with cleavage furrow (e. ...


Significance

The importance of mitosis is the maintenance of the chromosomal set; each cell formed receives chromosomes that are alike in composition and equal in number to the chromosomes of the parent cell. Transcription is generally believed to cease during mitosis, but epigenetic mechanisms such as bookmarking function during this stage of the cell cycle to ensure that the "memory" of which genes were active prior to entry into mitosis are transmitted to the daughter cells.[17] Epigenetic inheritance is the transmission of information from a cell or multicellular organism to its descendants without that information being encoded in the nucleotide sequence of the gene. ... Bookmarking is a biological phenomenon believed to function as an epigenetic mechanism for transmitting cellular memory of the pattern of gene expression in a cell through mitosis to its daughter cells. ...


Consequences of errors

Although errors in mitosis are rare, the process may go wrong, especially during early cellular divisions in the zygote. Mitotic errors can be especially dangerous to the organism because future offspring from this parent cell will carry the same disorder. It has been suggested that Biparental zygote be merged into this article or section. ...


In non-disjunction, a chromosome may fail to separate during anaphase. One daughter cell will receive both sister chromosomes and the other will receive none. This results in the former cell having three chromosomes coding for the same thing (two sisters and a homologue), a condition known as trisomy, and the latter cell having only one chromosome (the homologous chromosome), a condition known as monosomy. These cells are considered aneuploidic cells and these abnormal cells can cause cancer.[18] Aneuploidy is a change in the number of chromosomes that can lead to a chromosomal disorder. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...


Mitosis is a traumatic process. The cell goes through dramatic changes in ultrastructure, its organelles disintegrate and reform in a matter of hours, and chromosomes are jostled constantly by probing microtubules. Occasionally, chromosomes may become damaged. An arm of the chromosome may be broken and the fragment lost, causing deletion. The fragment may incorrectly reattach to another, non-homologous chromosome, causing translocation. It may reattach to the original chromosome, but in reverse orientation, causing inversion. Or, it may be treated erroneously as a separate chromosome, causing chromosomal duplication. The effect of these genetic abnormalities depend on the specific nature of the error. It may range from no noticeable effect, cancer induction, or organism death. A genetic deletion is a genetic aberration in which part of a chromosome is missing. ... Chromosomal translocation of the 4th and 20th chromosome. ... An inversion is a chromosome rearrangement in which a segment of a chromosome is reversed end to end. ... A duplication Chromosomal duplication occurs when a section of DNA is accidentally duplicated when a chromosome is copied. ...


Endomitosis

Endomitosis is a variant of mitosis without nuclear or cellular division, resulting in cells with many copies of the same chromosome occupying a single nucleus. This process may also be referred to as endoreduplication and the cells as endoploid.[2] Endoreduplication is the duplication of the genome without mitosis. ... Ploidy is the number of homologous sets of chromosomes in a biological cell. ...


Timeline in pictures

Real mitotic cells can be visualized through the microscope by staining them with fluorescent antibodies and dyes. These light micrographs are included below. Staining is a biochemical technique of adding a class-specific (DNA, proteins, lipids, carbohydrates) dye to a substrate to qualify or quantify the presence of a specific compound. ... Fluorescence induced by exposure to ultraviolet light in vials containing various sized cadmium selenide (CdSe) quantum dots. ... A dye can generally be described as a coloured substance that has an affinity to the substrate to which it is being applied. ...

References

  1. ^ De Souza CP, Osmani SA (2007). "Mitosis, not just open or closed". Eukaryotic Cell 6 (9): 1521–7. PMID 17660363. 
  2. ^ a b Lilly M, Duronio R (2005). "New insights into cell cycle control from the Drosophila endocycle.". Oncogene 24 (17): 2765-75. PMID 15838513. 
  3. ^ a b Blow J, Tanaka T (2005). "The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.". EMBO Rep 6 (11): 1028-34. PMID 16264427. 
  4. ^ Zhou J, Yao J, Joshi H (2002). "Attachment and tension in the spindle assembly checkpoint.". J Cell Sci 115 (Pt 18): 3547-55. PMID 12186941. 
  5. ^ Nanninga N (2001). "Cytokinesis in prokaryotes and eukaryotes: common principles and different solutions.". Microbiol Mol Biol Rev 65 (2): 319-33. PMID 11381104. 
  6. ^ Raven, Peter H.; Ray F. Evert, Susan E. Eichhorn (2005). Biology of Plants, 7th Edition. New York: W.H. Freeman and Company Publishers, 58-67. ISBN 0-7167-1007-2. 
  7. ^ Lloyd C, Chan J. (2006). "Not so divided: the common basis of plant and animal cell division.". Nat Rev Mol Cell Biol. 7 (2): 147-52. PMID 16493420. 
  8. ^ Heywood P. (1978). "Ultrastructure of mitosis in the chloromonadophycean alga Vacuolaria virescens.". J Cell Sci. 31: 37-51. PMID 670329. 
  9. ^ Ribeiro K, Pereira-Neves A, Benchimol M (2002). "The mitotic spindle and associated membranes in the closed mitosis of trichomonads.". Biol Cell 94 (3): 157-72. PMID 12206655. 
  10. ^ Chan G, Liu S, Yen T (2005). "Kinetochore structure and function.". Trends Cell Biol 15 (11): 589-98. PMID 16214339. 
  11. ^ a b Maiato H, DeLuca J, Salmon E, Earnshaw W (2004). "The dynamic kinetochore-microtubule interface.". J Cell Sci 117 (Pt 23): 5461-77. PMID 15509863. 
  12. ^ a b Winey M, Mamay C, O'Toole E, Mastronarde D, Giddings T, McDonald K, McIntosh J (1995). "Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle.". J Cell Biol 129 (6): 1601-15. PMID 7790357. 
  13. ^ Chan G, Yen T. "The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.". Prog Cell Cycle Res 5: 431-9. PMID 14593737. 
  14. ^ Glotzer M (2005). "The molecular requirements for cytokinesis.". Science 307 (5716): 1735-9. PMID 15774750. 
  15. ^ Albertson R, Riggs B, Sullivan W (2005). "Membrane traffic: a driving force in cytokinesis.". Trends Cell Biol 15 (2): 92-101. PMID 15695096. 
  16. ^ Raven, Peter H.; Ray F. Evert, Susan E. Eichhorn (2005). Biology of Plants, 7th Edition. New York: W.H. Freeman and Company Publishers, 64-67, 328-329. ISBN 0-7167-1007-2. 
  17. ^ Zhou G, Liu D, Liang C (2005). "Memory mechanisms of active transcription during cell division.". Bioessays 27 (12): 1239-45. PMID 16299763. 
  18. ^ Draviam V, Xie S, Sorger P (2004). "Chromosome segregation and genomic stability.". Curr Opin Genet Dev 14 (2): 120-5. PMID 15196457. 

Further reading

  • Morgan DO (2007) "The Cell Cycle: Principles of Control" London: New Science Press.
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, and Walter P (2002). Mitosis. Molecular Biology of the Cell. Garland Science. Retrieved on January 22, 2006.
  • Campbell, N. and Reece, J. (December 2001). "The Cell Cycle", Biology, 6th ed., San Francisco: Benjamin Cummings/Addison-Wesley, pp. 217-224. ISBN 0-8053-6624-5. 
  • Cooper, G. (2000). The Events of M Phase. The Cell: A Molecular Approach. Sinaeur Associates, Inc. Retrieved on January 22, 2006.
  • Freeman, S (2002). "Cell Division", Biological Science. Upper Saddle River, NJ: Prentice Hall, pp. 155-174. ISBN 0-13-081923-9. 
  • Lodish H, Berk A, Zipursky L, Matsudaira P, Baltimore D, Darnell J (2000). Overview of the Cell Cycle and Its Control. Molecular Cell Biology. W.H. Freeman. Retrieved on January 22, 2006.

is the 22nd day of the year in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ... is the 22nd day of the year in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ... is the 22nd day of the year in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ...

External links


  Results from FactBites:
 
Mitosis (418 words)
Mitosis is a special kind of cell division used by eukaryote cells.
Mitosis is really a division of the nucleus into two identical nuclei.
Before mitosis starts you cannot see any chromosomes in the nucleus, however, all the DNA in the nucleus is replicated exactly.
Mitosis - MSN Encarta (823 words)
Mitosis results in two cells that are genetically identical, a necessary condition for the normal functioning of virtually all cells.
Mitosis is vital for growth; for repair and replacement of damaged or worn out cells; and for asexual reproduction, or reproduction without eggs and sperm.
Mitosis continues in full-grown organisms as a means of maintaining the organism—replacing dying skin cells, for example, or repairing damaged muscle cells.
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