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Encyclopedia > Mesocortical pathway

The mesocortical pathway is a neural pathway which connects the ventral tegmentum to the cortex, particularly the frontal lobes. It is one of the major dopamine pathways in the brain.

It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe) and is thought to be involved in motivation and emotional response.

This pathway is thought to be associated with the negative symptoms of schizophrenia, which include avolition, alogia and flat affect (lack of emotional response).

Other major dopamine pathways include:

See also

  Results from FactBites:
Antipsychotic - Wikipedia, the free encyclopedia (1754 words)
receptors in the dopamine pathways in the brain, so the normal effect of dopamine release in the relevant synapses is reduced.
receptors in the mesolimbic pathway of the brain which is thought to produce the intended antipsychotic effect.
Typical antipsychotics are not particularly selective and also block the same receptors in the mesocortical pathway, tuberoinfundibular pathway and the nigrostriatal pathway.
  More results at FactBites »



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