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Encyclopedia > Melanogenesis

Melanogenesis is the production of the pigment melanin, responsible for skin colour. It is triggered by the damaging effect of ultraviolet rays. Ultraviolet rays penetrate the skin and damage DNA; thymidine dinucleotides (pTpT) fragments from damaged DNA will trigger release of the hormone alpha-MSH, which can then bind to melanocytes to cause them produce melanin. Melanin vesicles from the melanocytes are then transferred to surrounding keratinocytes. The skin will then be darker, when the keratinocytes which have been filled with melanin move toward the skin surface.


External links

  • The IFPCS presidential lecture: a chemist's view of melanogenesis (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12753395)

  Results from FactBites:
 
Melanogenesis - Wikipedia, the free encyclopedia (121 words)
Melanogenesis is the production of the pigment melanin, responsible for skin colour.
It is triggered by the damaging effect of ultraviolet rays.
The IFPCS presidential lecture: a chemist's view of melanogenesis
Study 4 Melanin 95 (10653 words)
Besides, it should be stressed that the various melanogenesis in vitro and in vivo are fluctuating chemical systems, in the sense predicted and studied by Piccardi (Florence) sensitive to variables of a terrestrial, solar and cosmic nature.
The melanogenesis of the tuberculosis bacillus is unclear as is that of the Mycobacerium nigrum.
The dopasemiquinone which is formed in the first stages of melanogenesis by oxidation of the DOPA also provides the explanation of the formation of different tricochromes (pheochromes) (1, d) from the various cysteinyldopas.
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