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Encyclopedia > Megakaryoblast

A megakaryoblast is a precursor cell to a promegakaryocyte, which in turn becomes a megakaryocyte. It is the beginning of the thrombocytic series. The megakaryocyte is a bone marrow cell responsible for the production of blood platelets when cytoplasm processes become fragmented. ...


It derives from an CFU-Me colony unit of pluripotential hemopoietic stem cells. Sketch of bone marrow and its cells Pluripotential hemopoietic stem cells or pluripotential hematopoietic stem cells (PHSCs) are stem cells found in the bone marrow. ...


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Blood - Blood plasma
Pluripotential hemopoietic stem cell - Red blood cells (Reticulocyte, Normoblast) - White blood cells
Lymphocytes (Lymphoblast)
T cells (Cytotoxic - Helper - Regulatory T cell) - B cells (Plasma cells & Memory B cells) - Natural killer cell
Myelocytes (Myeloblast)
Granulocytes (Neutrophil, Eosinophil, Basophil) - Monocytes (Histiocyte, Macrophages, Dendritic cells, Langerhans cells, Microglia, Kupffer cells) - Megakaryoblast - Megakaryocyte - Platelets

  Results from FactBites:
 
Interleukin-4 inhibits proliferation of human leukemic megakaryoblast cell line MHH 225. (240 words)
Interleukin-4 inhibits proliferation of human leukemic megakaryoblast cell line MHH 225.
Interleukin-4 inhibits proliferation of human leukemic megakaryoblast cell line MHH 225.The MHH 225 cells have been growing exponentially without cytokines or conditioned media.
After five days of treatment with erythropoietin, GM-CSF, G-CSF or IL-6 no change was observed in MHH 225 cell antigens expression.
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