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Encyclopedia > Mefenamic acid
Mefenamic acid
Systematic (IUPAC) name
2-(2,3-dimethylphenyl)aminobenzoic acid
Identifiers
CAS number 61-68-7
ATC code M01AG01
PubChem 4044
DrugBank APRD0073
Chemical data
Formula C15H15NO2 
Mol. mass 241.285 g/mol
Pharmacokinetic data
Bioavailability 90%
Protein binding 90%
Metabolism Hepatic (CYP2C9)
Half life 2 hours
Excretion Renal and fecal
Therapeutic considerations
Pregnancy cat.

C (Au, U.S.) Image File history File links Size of this preview: 800 × 444 pixelsFull resolution (2360 × 1310 pixel, file size: 2. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, symbol, number carbon, C, 6 Chemical series nonmetals Group, period, block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... BIC pen cap, about 1 gram. ... The mole (symbol: mol) is the SI base unit that measures an amount of substance. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... A drugs efficacy may be affected by the degree to which it binds to the proteins within blood plasma. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... The liver is an organ present in vertebrates and some other animals. ... Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. ... It has been suggested that Effective half-life be merged into this article or section. ... The hour (symbol: h) is a unit of time. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The kidneys are organs that filter wastes (such as urea) from the blood and excrete them, along with water, as urine. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... For other uses, see Australia (disambiguation). ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

℞-only (U.S.) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Routes Oral

Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is commercially available as Ponstel®. It is also prescribed as an antipyretic drug. It is typically prescribed for oral administration. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Menstrual cycle. ... Antipyretics are drugs that prevent or reduce fever by lowering the body temperature from a raised state. ...


Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... The uterus or womb is the major female reproductive organ of most mammals, including humans. ... Chemical structure of prostaglandin E1 (PGE1). ...


Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid. The liver is an organ present in vertebrates and some other animals. ... The kidneys are organs that filter wastes (such as urea) from the blood and excrete them, along with water, as urine. ... Kidneys Nephron Urine Large Intestine Lung Carbon dioxide Skin Sweat Bile Malphigian tubule system (Arthropod excretory system) Menses The Excretory system is responsible for the elimination of wastes produced by homeostasis. ...


Side effects

Mefenamic acid is known to cause an upset stomach, therefore it is recommended to take prescribed doses together with food or milk. Instances of drowsiness may also occur. As such, it is recommended to avoid driving or consuming alcohol while taking this medication. This article does not cite any references or sources. ...


Other known mild side effects of mefenamic acid include headaches, nervousness and vomiting. Serious side effects may include diarrhea, bloody vomit, blurred vision, skin rash, itching and swelling, sore throat and fever. It is advised to consult a doctor immediately if these symptoms appear while taking this medication. An adverse drug reaction (abbreviated ADR) is a term to describe the unwanted, negative consequences sometimes associated with the use of medications. ... A headache (cephalalgia in medical terminology) is a condition of pain in the head; sometimes neck or upper back pain may also be interpreted as a headache. ... Vomiting (or emesis) is the forceful expulsion of the contents of ones stomach through the mouth. ... Types 5-7 on the Bristol Stool Chart are often associated with diarrhea Diarrhea (in American English) or diarrhoea (in British English) is a condition in which the sufferer has frequent watery, loose bowel movements (from the Greek word διάρροια; literally meaning through-flowing). Acute infectious diarrhea is a common cause... This article needs additional references or sources for verification. ... The term symptom (from the Greek meaning chance, mishap or casualty, itself derived from συμπιπτω meaning to fall upon or to happen to) has two similar meanings in the context of physical and mental health: Strictly, a symptom is a sensation or change in health function experienced by a patient. ...


Sources

  • MedlinePlus Drug Information: Mefenamic Acid. Last accessed September 28, 2005.
  • Ponstel Pharmacology, Pharmacokinetics, Studies, Metabolism - Mefenamic Acid - RxList Monographs. Last accessed September 28, 2005.

  Results from FactBites:
 
Mefenamic acid Information on Healthline (797 words)
Mefenamic acid is used to reduce pain caused by various conditions including menstruation.
Mefenamic acid is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby.
Mefenamic acid should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart.
Spherical Agglomeration of Mefenamic Acid and Nabumetone to Improve Micromeritics and Solubility: A Technical Note (1780 words)
Mefenamic acid (2.5 g) was dissolved in 40 mL dimethylformamide (DMF) by gentle warming and the solution was added with stirring to 400 mL distilled water contained in the agglomerating vessel.
Mefenamic acid (2.5 g) was dissolved in 40 mL DMF by gentle warming and then cooled to 25ºC. A solution of 0.1% wt/vol of hydroxypropylmethyl cellulose (HPMC) in distilled water (30 mL) was then added to it with stirring.
Mefenamic acid in the aliquot was assayed spectrophotometrically at 285 nm.
  More results at FactBites »

 
 

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