The marginal zone is a portion of the spleen. The spleen is a ductless, vertebrate gland that is not necessary for life but is closely associated with the circulatory system, where it functions in the destruction of old red blood cells and removal of other debris from the bloodstream, and also in holding a reservoir of blood. ...
Marginal zone lymphocytes are a type of B cell ("MZ B cell") created there, capable of binding IgM-antigen complexes. They are notable for their ability to serve several different roles in the immune system. A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... Schematic of antibody binding to an antigen An antibody is a protein complex used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... The immune system is the system of specialised cells and organs that protect an organism from outside biological influences. ...
It is associated with three different kinds of lymphoma: Lymphoma is a general term for a variety of cancer that begins in the lymphatic system. ...
Splenic marginal zone lymphoma
Extranodal marginal zone B cell lymphoma (MALT lymphoma, or "mucosa-associated lymphoid tissue")
MarginalZone Lymphomas are a related cancers of the lymphatic system - a complex system of lymph organs, including the bone marrow, thymus, spleen, and the lymph nodes.
MarginalZone NHL is the most common type of b-cell lymphoma, comprising approximately 2-4% of all cases.
MarginalZone Lymphomas and Hepatitis C: Splenic and nodal marginalzone lymphomas are indolent disorders at high hepatitis C virus seroprevalence with distinct presenting features but similar morphologic and phenotypic profiles.
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