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Encyclopedia > Marginal zone

The marginal zone is a portion of the spleen. The spleen is a ductless, vertebrate gland that is not necessary for life but is closely associated with the circulatory system, where it functions in the destruction of old red blood cells and removal of other debris from the bloodstream, and also in holding a reservoir of blood. ...

Marginal zone lymphocytes are a type of B cell ("MZ B cell") created there, capable of binding IgM-antigen complexes. They are notable for their ability to serve several different roles in the immune system. A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... Schematic of antibody binding to an antigen An antibody is a protein complex used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... The immune system is the system of specialised cells and organs that protect an organism from outside biological influences. ...

It is associated with three different kinds of lymphoma: Lymphoma is a general term for a variety of cancer that begins in the lymphatic system. ...

  • Splenic marginal zone lymphoma
  • Extranodal marginal zone B cell lymphoma (MALT lymphoma, or "mucosa-associated lymphoid tissue")
  • Nodal marginal zone B cell lymphoma (NMZL)

See also

Humoral immunity is mediated by secreted antibodies, produced in the cells of the B lymphocyte lineage (B cell). ...

External links

  • Annual Review of Immunology
  • BioMedCentral
  • Marginal zone lymphomas
  • JEM
  • Spleen
  • Spleen

  Results from FactBites:
Marginal Zone Lymphomas (1287 words)
Marginal Zone Lymphomas are a related cancers of the lymphatic system - a complex system of lymph organs, including the bone marrow, thymus, spleen, and the lymph nodes.
Marginal Zone NHL is the most common type of b-cell lymphoma, comprising approximately 2-4% of all cases.
Marginal Zone Lymphomas and Hepatitis C: Splenic and nodal marginal zone lymphomas are indolent disorders at high hepatitis C virus seroprevalence with distinct presenting features but similar morphologic and phenotypic profiles.
  More results at FactBites »



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