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Encyclopedia > Lymphocytic choriomeningitis
Lymphocytic Choriomeningitis Virus
Virus classification
Group: Group V ((-)ssRNA)
Family: Arenaviridae
Genus: Arenavirus
Species: Lymphocytic Choriomeningitis Virus

Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the Lymphocytic Choriomeningitis Virus (LCMV), a member of the family Arenaviridae. Viruses can be classified in several ways, such as by their geometry, by whether they have envelopes, by the identity of the host organism they can infect, by mode of transmission, or by the type of disease they cause. ... An RNA virus is a virus that either uses RNA as its genetic material, or whose genetic material passes through an RNA intermediate during replication. ... Families Many, see text The order Rodentia is the most numerous of all the branches on the mammal family tree. ... Meningitis is inflammation of the membranes (meninges) covering the brain and the spinal cord. ... Encephalitis is an acute inflammation of the brain, commonly caused by a viral infection. ... Arenavirus is a genus of virus. ...


Virus biology

The first arenavirus, lymphocytic choriomeningitis virus (LCMV), was isolated in 1933 during a study of an epidemic of St. Louis encephalitis. Although not the cause of the outbreak, LCMV was found to be a cause of aseptic (nonbacterial) meningitis. LCMV is a reverse strand single stranded RNA virus. St. ... An RNA virus is a virus that either uses RNA as its genetic material, or whose genetic material passes through an RNA intermediate during replication. ...


Infection

LCMV is naturally spread by the common house mouse, Mus musculus. Once infected, these mice can become chronically infected by maintaining virus in their blood and/or persistently shedding virus in their urine. Chronically infected female mice usually transmit infection to their offspring, which in turn become chronically infected. About five per cent of mice, hamsters and rodents are thought to carry the disease. Binomial name Mus musculus Linnaeus, 1758 Mus musculus is the house mouse. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Urine is liquid waste excreted by the kidneys and eventually expelled from the body in a process known as urination. ...


Humans become infected by inhaling infectious aerosolized particles of rodent urine, feces, or saliva, by ingesting food contaminated with virus, by contamination of mucus membranes with infected body fluids, or by directly exposing cuts or other open wounds to virus-infected blood. Person-to-person transmission has not been reported, with the exception of vertical transmission from an infected mother to fetus. Feces (also spelled faeces in British English, or fæces) are semi-solid waste products from the digestive tract expelled through the anus (or cloaca) during defecation. ... For the band, see Saliva (band). ... Fetus at eight weeks A fetus (alternatively foetus or fœtus) is an embryo in later stages of development, from the third month of pregnancy until birth in humans. ...


About two per cent of the US population have been exposed to the virus. The virus normally has little effect on healthy people but can be deadly for people whose immune system has been weakened. The death of at least six organ transplant patients in the US have been linked to the virus as at May 2005.


References

  • Centers for Disease Control and Prevention. Lymphocytic Choriomeningitis Fact Sheet (http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/Fact_Sheets/Lymphocytic_Choriomeningitis_Fact_Sheet.pdf)
  • Associated Press story about deaths linked to virus (http://story.news.yahoo.com/news?tmpl=story&cid=541&e=5&u=/ap/transplant_deaths)

  Results from FactBites:
 
EID V1 N4: Lymphocytic Choriomeningitis Virus: An Unrecognized Teratogenic Pathogen (1224 words)
Lymphocytic choriomeningitis virus (LCMV), the first member of the arenavirus family to be isolated, is the causative agent of a zoonosis acquired from chronically viremic mice or hamsters (1).
Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore.
Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an intercity population.
  More results at FactBites »

 
 

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