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Encyclopedia > Luis Federico Leloir
Luis Federico Leloir
An early photograph of Leloir in his twenties
An early photograph of Leloir in his twenties
Born September 06, 1906(1906-09-06)
Paris, France
Died December 2, 1987 (aged 81)
Buenos Aires, Argentina
Residence Buenos Aires, Argentina
Citizenship Flag of Argentina Argentina
Ethnicity Basque
Field Biochemistry
Institutions University of Buenos Aires
Washington University in St. Louis (1943-1945)
Fundación Instituto Campomar (1947-1981)
University of Cambridge (1936-1943)
Alma mater University of Buenos Aires
Known for galactosemia
lactose intolerance
carbohydrate metabolism
Notable prizes Nobel Prize in Chemistry (1970)
French Legion of Honor (1982)

Luis Federico Leloir (September 6, 1906December 2, 1987) was an Argentine doctor and biochemist who received the 1970 Nobel Prize in Chemistry. Along with Mario Molina, he is one of the first two Hispanic scientists to ever receive the award. Although born in France, Leloir received the majority of his education at the University of Buenos Aires and was director of the private research group Fundación Instituto Campomar until his death in 1987. Although his laboratories were often plagued by lack of financial support and second-rate equipment, his research into sugar nucleotides, carbohydrate metabolism, and renal hypertension has garnered international attention and fame and has led to significant progress in understanding, diagnosing and treating the congenital disease galactosemia. Image File history File links Download high-resolution version (755x959, 97 KB) Summary Image from Leloirs Biography at the Houssays page. ... September 6 is the 249th day of the year (250th in leap years). ... 1906 (MCMVI) was a common year starting on Monday (see link for calendar). ... City flag City coat of arms Motto: Fluctuat nec mergitur (Latin: Tossed by the waves, she does not sink) Paris Eiffel tower as seen from the esplanade du Trocadéro. ... December 2 is the 336th day (337th in leap years) of the year in the Gregorian calendar. ... 1987 (MCMLXXXVII) was a common year starting on Thursday of the Gregorian calendar. ... For other uses, see Buenos Aires (disambiguation). ... Image File history File links Flag_of_Argentina. ... Languages Basque - few monoglots Spanish - 1,525,000 monoglots French - 150,000 monoglots Basque-Spanish - 600,000 speakers Basque-French - 76,000 speakers [4] other native languages Religions Traditionally Roman Catholic The Basques (Basque: Euskaldunak) are an indigenous people[] who inhabit parts of both Spain and France. ... Biochemistry is the study of the chemical processes and transformations in living organisms. ... The Universidad de Buenos Aires (UBA) is the largest university in Argentina, founded on August 12, 1821 in the city of Buenos Aires. ... Washington University in St. ... The University of Cambridge (often Cambridge University), located in Cambridge, England, is the second-oldest university in the English-speaking world and has a reputation as one of the worlds most prestigious universities. ... Galactosemia is a rare genetic metabolic disorder which affects an individuals ability to properly digest the sugar galactose. ... The smooth endoplasmic reticulum is responsible for some carbohydrate metabolism. ... Image File history File links Nobel. ... This is a list of Nobel Prize laureates in Chemistry from 1901 to 2006. ... French Legion of Honor The Légion dhonneur (in Legion of Honor (AmE) or Legion of Honour (ComE)) is an Order of Chivalry awarded by the President of France. ... September 6 is the 249th day of the year (250th in leap years). ... 1906 (MCMVI) was a common year starting on Monday (see link for calendar). ... December 2 is the 336th day (337th in leap years) of the year in the Gregorian calendar. ... 1987 (MCMLXXXVII) was a common year starting on Thursday of the Gregorian calendar. ... 1970 (MCMLXX) was a common year starting on Thursday. ... The Nobel Prizes (Swedish: ) are awards in Physics, Chemistry, Literature, Peace, Physiology or Medicine and Economics. ... Mario J. Molina (born March 19, 1943) was awarded the 1995 Nobel Prize in Chemistry for his role in elucidating the threat to the Earths ozone layer of chlorofluorocarbon gases (or CFCs). ... A nucleotide is an organic molecule consisting of a heterocyclic nucleobase (a purine or a pyrimidine), a pentose sugar (deoxyribose in DNA or ribose in RNA), and a phosphate or polyphosphate group. ... Lactose is a disaccharide found in milk. ... Kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... This article or section does not cite its references or sources. ... Galactosemia is a rare genetic metabolic disorder which affects an individuals ability to properly digest the sugar galactose. ...

Contents

Biography

Early years

Leloir's parents, Federico and Hortensia Aguirre Leloir, traveled from Buenos Aires to Paris in the middle of 1906 with the intention of operating on Federico's illness. However, Federico died in late August, and a week later Luis was born in an old house at 81 Víctor Hugo Road in Paris, a few blocks away from the Arc de Triumph[1]. After returning to Argentina in 1908, Leloir lived together with his eight siblings on their family's extensive property(El Tuyú- 40,000 hectares of rocky land that included the coastline from San Clemente del Tuyú to Mar de Ajó; it has since become a popular tourist attraction[2]) that his grandparents had purchased after their immigration from the Basque Country of northern Spain. Arc de Triomphe The Arc de Triomphe is a monument in Paris that stands in the centre of the Place de lÉtoile, at the western end of the Champs-Élysées. ... 1908 (MCMVIII) was a leap year starting on Wednesday (link will display the full calendar). ... The Ikurriña, Basque flag Location of Territory of the Basque Country The Basque Country divided in seven provinces. ...


During his childhood, the future Nobel Prize winner found himself observing natural phenomenon with particular interest; his schoolwork and readings highlighted the connections between the natural sciences and biology. His education was divided between Escuela General San Martín(primary school), Colegio Lacordaire(secondary school), and for a few months at Beaumont College in England. His grades were unspectacular, and his first stint in college ended quickly when he abandoned his architectural studies that he had begun in Paris' Instituto Politécnico.[3] Beaumont College was a Catholic public school for boys alongside the River Thames in Old Windsor, Surrey. ... Motto (French) God and my right Anthem God Save the King (Queen) England() – on the European continent() – in the United Kingdom() Capital (and largest city) London (de facto) Official languages English (de facto) Government Constitutional monarchy  -  Queen Queen Elizabeth II  -  Prime Minister Tony Blair MP Unification  -  by Athelstan 967  Area...


It was during the 1920s that Leloir supposedly invented salsa golf (golf sauce). After being served prawns with the usual sauce during lunch with a group of friends at the Ocean Club in Mar del Plata, Leloir came up with a peculiar combination of ketchup and mayonnaise to spice up his meal. With the financial difficulties that later plagued Leloir's laboratories and research, he would joke, "If I had patented that sauce, we'd have a lot more money for research right now".[4]


Career

Buenos Aires

Leloir(top left) with family on the Argentine coastline, 1951.
Leloir(top left) with family on the Argentine coastline, 1951.

After returning again to Argentina, Leloir obtained his Argentine citizenship and joined the Department of Medicine at the University of Buenos Aires in hopes of receiving his doctorate. However, he got off to a rocky start, requiring four attempts to pass his anatomy exam.[5] He finally received his diploma in 1932 and began his residency in the Hospital de Clínicas and his medical internship in Ramos Mejía hospital. After some initial conflicts with colleagues and complications in his method of treating patients, Leloir decided to dedicate himself to research in the laboratory, claiming that "we could do little for our patients... antibiotics, psychoactive drugs, and all the new therapeutic agents were unknown [at the time]"[1]. Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... 1951 (MCMLI) was a common year starting on Monday; see its calendar. ...


In 1933, he met Bernardo A. Houssay, who pointed Leloir towards investigating in his doctoral thesis the suprarenal glands and carbohydrate metabolism. Houssay happened to be friends with Carlos Bonorino Udaondo, the brother-in-law of Victoria Ocampo, one of Leloir's cousins. Following the recommendation of Udaondo, Leloir began working with Houssay, who in 1947 would later win the Nobel Prize for Physiology or Medicine. The two would develop a close relationship, collaborating on various projects until Houssay's death in 1971; in his lecture after winning the Nobel Prize, Leloir claimed that his "whole research career has been influenced by one person, Prof. Bernardo A. Houssay".[1][6] 1933 (MCMXXXIII) was a common year starting on Sunday. ... Bernardo Alberto Houssay (April 10, 1887–September 21, 1971) was an Argentinian physiologist who received (with Carl and Gerty Cori) the 1947 Nobel Prize for Physiology or Medicine for his discovery of the role played by pituitary hormones in regulating the amount of blood sugar (glucose) in animals. ... In mammals, the adrenal gland (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit atop the kidneys; their name indicates that position (ad, near or at + renes, kidneys). They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines, including cortisol... Victoria Ocampo (April 7, 1890? - January 27, 1979) was an Argentine intellectual, described by Jorge Luis Borges as la mujer más argentina (the most Argentine woman). Best known as an advocate for others and as publisher of the magazine Sur, she was also a writer and critic in her... 1947 (MCMXLVII) was a common year starting on Wednesday (the link is to a full 1947 calendar). ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ...


Cambridge

After only two years, Leloir received recognition from the medical department at UBA for having produced the best doctoral thesis. Feeling that his knowledge in fields such as physics, mathematics, chemistry, and biology was lacking, he continued attending classes at the University as a part-time student. In 1936 he traveled to England to begin advanced studies at the University of Cambridge, under the supervision of another Nobel Prize winner, Sir Frederick Gowland Hopkins, who had obtained that distinction in 1929 for his work in physiology and in revealing the critical role of vitamins in maintaining good health. Leloir's research in the Biochemical Laboratory of Cambridge centered around enzymes, more specifically the effects of cyanide and pyrophosphate on succinic dehydrogenase; from this moment Leloir began to specialize in researching carbohydrate metabolism. Physics (Greek: (phúsis), nature and (phusiké), knowledge of nature) is the branch of science concerned with the fundamental laws of the universe. ... Euclid, Greek mathematician, 3rd century BC, as imagined by by Raphael in this detail from The School of Athens. ... Chemistry - the study of atoms, made of nuclei (conglomeration of center particles) and electrons (outer particles), and the structures they form. ... This article or section does not cite any references or sources. ... 1936 (MCMXXXVI) was a leap year starting on Wednesday (link will take you to calendar). ... The University of Cambridge (often Cambridge University), located in Cambridge, England, is the second-oldest university in the English-speaking world and has a reputation as one of the worlds most prestigious universities. ... Sir Frederick Gowland Hopkins (1861 - 1947) was an English biochemist. ... 1929 (MCMXXIX) was a common year starting on Tuesday (link will take you to calendar). ... Leonardo da Vincis Vitruvian Man, an important early achievement in the study of physiology. ... Retinol (Vitamin A) Vitamins are nutrients required in very small amounts for essential metabolic reactions in the body [1]. The term vitamin does not encompass other essential nutrients such as dietary minerals, essential fatty acids, or essential amino acids. ... Neuraminidase ribbon diagram An enzyme (in Greek en = in and zyme = blend) is a protein, or protein complex, that catalyzes a chemical reaction and also controls the 3D orientation of the catalyzed substrates. ... The cyanide ion, CN−. From the top: 1. ... In chemistry, the anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. ...


United States

Leloir returned to Buenos Aires in 1937 after his brief stay at Cambridge. 1943 saw Leloir marry; Luis Leloir and Amelia Zuberbuhler would later have a daughter also named Amelia. However, his return to Argentina was amidst conflict and strife; Houssay had been expelled from the University of Buenos Aires for signing a public petition opposing the fascist Nazi regime in Germany and the military government led Pedro Pablo Ramírez. Leloir fled to the United States, where he assumed the position of associate professor in the Department of Pharmacology at Washington University in St. Louis, collaborating with Carl Cori and Gerty Cori and David E. Green at Columbia University as a research assistant. Leloir would late credit Green with instilling within him the initiative to establish his own research group once back in Argentina[1]. 1937 (MCMXXXVII) was a common year starting on Friday (link will take you to calendar). ... 1943 (MCMXLIII) was a common year starting on Friday (the link is to a full 1943 calendar). ... Fascism (in Italian, fascismo), capitalized, was the authoritarian political movement which ruled Italy from 1922 to 1943 under the leadership of Benito Mussolini. ... National Socialism redirects here. ... General Pedro Pablo Ramírez Machuca (1884 - 1962) was President of Argentina from June 7, 1943 to February 24, 1944. ... Pharmacology (in Greek: pharmacon (φάρμακον) meaning drug, and logos (λόγος) meaning science) is the study of how substances interact with living organisms to produce a change in function. ... Washington University in St. ... Carl Ferdinand Cori (December 5, 1896 _ October 20, 1984) was an American biochemist born in Prague (then in Austria-Hungary) who, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in 1947 for their discovery of how glycogen (animal starch) - a derivative of... Dr. Gerty Cori Dr. Gerty Theresa Cori, née Radnitz, (August 15, 1896 – October 26, 1957) was an American biochemist born in Prague (then Austria-Hungary) who, together with her husband Carl Ferdinand Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in Physiology or Medicine in 1947 for... Columbia University is a private research university in the United States. ...


Fundación Instituto Campomar

Luis Leloir and Carlos Eugenio Cardini at work in Fundación Instituto Campomar, 1960.
Luis Leloir and Carlos Eugenio Cardini at work in Fundación Instituto Campomar, 1960.

In 1945 Leloir ended his exile and returned to Argentina to work under Houssay at the Instituto de Investigaciones Bioquímicas de la Fundación Campomar, which Leloir would direct from its creation in 1947 by businessman and patron Jaime Campomar. Initially, the institute was composed of five rooms, a bathroom, central hall, patio, kitchen, and changing room.[7] During the final years of the 1940s, although lacking financial resources and operating with very low-cost teams, Leloir's successful experiments would reveal the chemical origins of sugar synthesis in yeast as well as the oxidation of fatty acids in the liver; together with J. M. Muñoz, he produce an active cell-free system, a first in scientific research. It had initially been assumed that in order to study a cell, scientists could not separate it from its host organism, as oxidation could only occur in intact cells.[8] Along the way, Muñoz and Leloir, unable to procure the costly centrifuge needed to separate cell contents, improvised by spinning a tire stuffed with salt and ice.[9] Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... 1945 (MCMXLV) was a common year starting on Monday. ... 1947 (MCMXLVII) was a common year starting on Wednesday (the link is to a full 1947 calendar). ... Typical divisions Ascomycota (sac fungi) Saccharomycotina (true yeasts) Taphrinomycotina Schizosaccharomycetes (fission yeasts) Basidiomycota (club fungi) Urediniomycetes Sporidiales Yeasts are a growth form of eukaryotic microorganisms classified in the kingdom Fungi. ... The most fundamental reactions in chemistry are the redox processes. ... In chemistry, especially biochemistry, a fatty acid is a carboxylic acid (or organic acid), often with a long aliphatic tail (long chains), either saturated or unsaturated. ...


By 1947 he had formed a team that included Rawell Caputo, Enrico Cabib, Raúl Trucco, Alejandro Paladini, Carlos Cardini y José Luis Reissig, with whom he investigated and discovered why a malfunctioning kidney and angiotensin helped cause hypertension.[10] That same year, his colleague Rawell Caputo, in his investigations of the mammary gland, made discoveries regarding carbohydrate storage and its subsequent transformation into a reserve energy form in organisms. 1947 (MCMXLVII) was a common year starting on Wednesday (the link is to a full 1947 calendar). ... Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. ... Arterial hypertension, or high blood pressure is a medical condition where the blood pressure is chronically elevated. ... Mammary glands are the organs that, in the female mammal, produce milk for the sustenance of the young. ...

Chemical structure of galactose. Leloir and his team discovered that in galactosemia, patients lacked the necessary enzyme (Galactose-1-phosphate uridyl transferase) to convert unusable galactose into usuable glucose.
Chemical structure of galactose. Leloir and his team discovered that in galactosemia, patients lacked the necessary enzyme (Galactose-1-phosphate uridyl transferase) to convert unusable galactose into usuable glucose.

At the beginning of 1948, Leloir and his team identified the sugar nucleotides that were fundamental to the metabolism of carbohydrates, turning the Instituo Campomar into a biochemistry institution well-known throughout the world. Immediately thereafter, Leloir received the Argentine Scientific Society Prize, one of the many awards he would receive both in Argentina and internationally. During this time, his team dedicated itself to the study of glycoproteins; Leloir and his colleagues elucidated the primary mechanisms of galactose metabolism (now coined the Leloir pathway[11]) and determined the cause of galactosemia, a serious genetic disorder that resulted in lactose intolerance. Wikipedia does not have an article with this exact name. ... Wikipedia does not have an article with this exact name. ... Galactose (also called brain sugar) is a type of sugar found in dairy products, in sugar beets and other gums and mucilages. ... 1948 (MCMXLVIII) was a leap year starting on Thursday (the link is to a full 1948 calendar). ... A glycoprotein is a macromolecule composed of a protein and a carbohydrate (a sugar). ... A genetic disorder or a clinical phenotype. ...


The following year, he reached an agreement with Roland Garcia, dean of the Department of Natural Sciences at UBA, which named Leloir, Carlos Eugenio Cardini and Enrico Cabib as titular professors in the University's newly founded Biochemical Institute. The Institute would help develop scientific programs in budding Argentinian universities as well as attract researchers and scholars from the United States, Japan, England, France, Spain, and other Latin American countries.


Following Campomar's death in 1957, Leloir and his team applied to the National Institutes of Health in the United States desperate for funding, and surprisingly was accepted. In 1958, the Institute found a new home in a former all-girls school, a donation from the Argentine government. As Leloir and his research gained greater prominence, further research came from the Argentine Research Council, and the Institute would later become associated with the University of Buenos Aires.[12] 1957 (MCMLVII) was a common year starting on Tuesday of the Gregorian calendar. ... The National Institutes of Health (NIH) is the primary agency of the United States government responsible for medical research. ... Year 1958 (MCMLVIII) was a common year starting on Wednesday of the Gregorian calendar. ...


Later years

Leloir celebrating with colleagues December 10, 1970 after winning the Nobel Prize.
Leloir celebrating with colleagues December 10, 1970 after winning the Nobel Prize.

As his work in the laboratory was coming to an end, Leloir continued his teaching position in the Department of Natural Sciences at the University of Buenos Aires, taking a hiatus only to complete his studies at Cambridge and at the Enzyme Research Laboratory in the United States. Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... December 10 is the 344th day (345th in leap years) of the year in the Gregorian calendar, 21 days before the next year. ... 1970 (MCMLXX) was a common year starting on Thursday. ...


In 1983, Leloir became one of the founding members of the Third World Academy of Sciences. TWAS, the academy of sciences for the developing world -- until 2004 named Third World Academy of Sciences -- is a merit-based science academy uniting more than 750 scientists from 89 countries. ...


Nobel Prize

On December 2nd, 1970, Leloir received the Nobel Prize for Chemistry from the King of Sweden for his discovery of the metabolic pathways in lactose, becoming only the third Argentine to receive the prestigious honor in any field. In his acceptance speech at Stockholm, he borrowed Winston Churchill's famous 1940 speech to the House of Commons and remarked, "never have I received so much for so little".[13] Leloir and his team reportedly celebrated by drinking champagne from test tubes, a rare departure from the humbleness and frugality that characterized the atmosphere of Fundación Instituto Campomar under Leloir's direction. The $80,000 prize money was spent directly on research,[14] and when asked about the significance of his achievement, Leloir responded:[15] 1970 (MCMLXX) was a common year starting on Thursday. ... Nickname: Location of Stockholm in northern Europe Coordinates: Country Sweden Municipality Stockholm Municipality County Stockholm Province Södermanland and Uppland Charter 13th Century Population (April 2007)  - City 782,885  - Density 4,160/km² (10,774. ... Sir Winston Leonard Spencer-Churchill, KG, OM, CH, TD, FRS, PC (Can) (30 November 1874 – 24 January 1965) was a British statesman, soldier, and author. ... The House of Commons is the lower house of the Parliament of the United Kingdom. ...

"This is only one step in a much larger project. I discovered(no, not me: my team) the function of sugar nucleotides in cell metabolism. I want others understood this, but it is not easy to explain. This is not a very noteworthy deed; we hardly know even a little."

Legacy

Leloir published a short autobiography, entitled "Long Ago and Far Away" in the 1983 Annual Review of Biochemistry. The title, Leloir claims, is derived from one of William Henry Hudson's novels that depicted the country wildlife and scenery of Leloir's childhood[1]. 1983 (MCMLXXXIII) was a common year starting on Saturday of the Gregorian calendar. ... William H. Hudson William Henry Hudson (August 4, 1841 - August 18, 1922) was an Argentinan-British author, naturalist and ornithologist. ...


He died in Buenos Aires December 2, 1987 of a heart attack soon after returning to his home from the laboratory, and is buried in La Recoleta Cemetery. Mario Bunge, a friend and colleague of Leloir, claims that his lasting legacy was proving that "scientific research on an international level, although precarious, was possible in an underdeveloped country in the middle of political strife" and credits Leloir's vigilance and will for his ultimate success.[16] With his research in dire financial straits, Leloir often resorted to homemade gadgets and contraptions to continue his work in the laboratory. In one instance, Leloir reportedly used waterproof cardboard to create makeshift gutters in order to protect his laboratory's library from the rain.[17] December 2 is the 336th day (337th in leap years) of the year in the Gregorian calendar. ... 1987 (MCMLXXXVII) was a common year starting on Thursday of the Gregorian calendar. ... La Recoleta Cemetery is a famous cemetery located in the exclusive Recoleta neighbourhood of Buenos Aires, Argentina. ... Mario Augusto Bunge (born September 21, 1919, Buenos Aires) is an Argentinian philosopher and physicist mainly active in Canada. ...


Leloir was known for his humbleness, focus and consistency, described by many as a "true monk in science".[18] Every morning his wife Amelia would drive him in their Fiat 600 and drop him off at 1719 Julián Alvarez Street, location of Fundación Instituto Campomar, with Leloir wearing the same worn out, gray overalls. He worked sitting on the same straw seat for decades and encouraged colleagues to eat lunch in the laboratory to save time, bringing enough meat stew to share with everyone.[19] Indeed, despite Leloir's frugality and extreme dedication to his research, he was a sociable man, claiming not to like working alone.[20] The Fiat 600 (or Seicento) is a city car produced by the Italian automaker Fiat from 1955 to 1969. ...


The Fundación Instituto Campomar has since been renamed Fundación Instituto Leloir, and has grown to become a 21,000 sq. foot building with 20 senior researchers, 42 technicians and administrative personnel, 8 post doctorate fellows, and 20 Ph.D. candidates. The Institute conducts research in a variety of fields, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.[21]


Awards and distinctions

Leloir(left) with Armando Parodi and his daughter Amelia in the laboratory.
Leloir(left) with Armando Parodi and his daughter Amelia in the laboratory.
Leloir with his wife Amelia and cardiac surgeon René Favaloro.
Leloir with his wife Amelia and cardiac surgeon René Favaloro.
Year Distinction
1943 Third National Science Award
1958 T. Ducett Jones Memorial Award
1965 Bunge and Born Foundation Award
1966 Gairdner Foundation Award
1967 Columbia University's Louise Gross Horwitz Award
1968 Benito Juárez Award
1968 Honorary Doctorate from Universidad Nacional de Córdoba
1968 Argentina Chemistry Association's José Jolly Kyle Award
1969 Honorary member of the English Biochemical Society
1970 Nobel Prize for Chemistry
1971 Legion de Honor “Orden de Andrés Bello”
1976 Bernardo O'Higgins en el Grado de Gran Cruz
1982 French Legion of Honor

Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... 1943 (MCMXLIII) was a common year starting on Friday (the link is to a full 1943 calendar). ... Year 1958 (MCMLVIII) was a common year starting on Wednesday of the Gregorian calendar. ... 1965 (MCMLXV) was a common year starting on Friday (the link is to a full 1965 calendar). ... 1966 (MCMLXVI) was a common year starting on Saturday (the link is to a full 1966 calendar). ... 1967 (MCMLXVII) was a common year starting on Sunday of the Gregorian calendar (the link is to a full 1967 calendar). ... Columbia University is a private research university in the United States. ... 1968 (MCMLXVIII) was a leap year starting on Monday. ... For the Stargate SG-1 episode, see 1969 (Stargate SG-1). ... 1970 (MCMLXX) was a common year starting on Thursday. ... 1971 (MCMLXXI) was a common year starting on Friday. ... 1976 (MCMLXXVI) was a leap year starting on Thursday. ... 1982 (MCMLXXXII) was a common year starting on Friday of the Gregorian calendar. ... French Legion of Honor The Légion dhonneur (in Legion of Honor (AmE) or Legion of Honour (ComE)) is an Order of Chivalry awarded by the President of France. ...

Published works

  • "Suprarrenales y Metabolismo de los hidratos de carbono", (1934)
  • "Farmacología de la hipertensina", (1940)
  • "Hipertensión arterial nefrógena, (1943)
  • "Perspectives in Biology", (1963)
  • "Renal Hipertensión", (1964)
  • "In Vitro Synthesis of Particulate Glycogen", (1965)
  • "Properties of Synthetic and Native liver Glycogen", (1967)
  • "Faraway and Long ago", (1983)
  • "Lipid-bond Saccharides containing glucose and galactose in agrobacterium tumefaciens", (1984)
  • "An Intermediail in Cyclic 1-2 Glucan Biosynthesis", (1985)
  • "Structural correspondence between an oligosaccharide bound to a lipid with the repeating unit of the Rhizobium meliloti" (M. E. Tolmasky, R. J. Staneloni, and L. F. Leloir), Anales de la Asociación Química Argentina (1982) no.70 pg.833-842.
  • "N-glycosilation of the proteins" (M. E. Tolmasky, H. K. Takahashi, R. J. Staneloni, and L. F. Leloir), Anales de la Asociación Química Argentina (1982) no.70 pg.405-411.
  • "Transfer of oligosaccharide to protein from a lipid intermediate in plants" (R. J. Staneloni, M. E. Tolmasky, C. Petriella, and L. F. Leloir), Plant Physiology (1981) no.68 pg.1175-1179.
  • "Presence in a plant of a compund similar to the dolichyl diphosphate oligosaccharide of animal tissue" (R. J. Staneloni, M. E. Tolmasky, C. Petriella, R. A. Ugalde, and L. F. Leloir), Biochemical Journal (1980) no.191 pg.257-260.
  • "Lipid bound sugars in Rhizobium meliloti" (M. E. Tolmasky, R. J. Staneloni , R. A. Ugalde, and L. F. Leloir), Archives of Biochemistry and Biophysics (1980) no.203 pg.358-364.

References

  1. ^ a b c d e Luis Federico Leloir, "Long Ago and Far Away"
  2. ^ welcomeargentina.com, "San Clemente del Tuyú: Historia de la ciudad y leyendas de la zona" web:http://www.welcomeargentina.com/sanclementedeltuyu/historia.html
  3. ^ "Cientificos Argentinos Distinguidos Con El Premio Nobel En Ciencia" web:http://www.oni.escuelas.edu.ar/olimpi98/ConociendoNuestraCiencia/nobel%20leloir.html
  4. ^ Pedro Tesone (2006). Luis Federico Leloir. Sociedad Argentina de Diabetes. Retrieved on 2007-03-19.
  5. ^ Valeria Roman, "A cien años del nacimiento de Luis Federico Leloir" web:http://www.clarin.com/diario/2006/08/27/sociedad/s-01259864.htm
  6. ^ Luis Leloir, "Two decades of research on the biosynthesis of saccharides" web:http://nobelprize.org/nobel_prizes/chemistry/laureates/1970/leloir-lecture.html
  7. ^ Ariel Barrios Medina, "Luis Federico Leloir (1906-1987): un esbozo biográfico" web: http://www.houssay.org.ar/hh/bio/leloir.htm
  8. ^ Nicole Kresge, Robert D. Simoni, and Robert L. Hill, "Luis F. Leloir and Biosynthesis of Saccharides" web:http://www.jbc.org/cgi/content/full/280/19/e16
  9. ^ Ariel Barrios Medina, "Luis Federico Leloir (1906-1987): un esbozo biográfico" web: http://www.houssay.org.ar/hh/bio/leloir.htm
  10. ^ "The Substance Causing Renal Hypertension"(E. Braun-Menedez, J.C. Fasciolo, L.F. Leloir, J.M. Muñoz)The Journal of Physiology(1940) no.98 pg.283-298
  11. ^ Holton JB, Walter JH, and Tyfield LA. “Galactosemia” in The Metabolic and Molecular Bases of Inherited Disease, 8th edition, 2001. Scriver, Beaudet, et al., McGraw-Hill, vol I, chapter 72 , p.1553-1587.
  12. ^ World of Scientific Discovery, Thomas Gale, Thomson Corporation, 2005-2006
  13. ^ Nobelprize.org: "Luis Leloir- Banquet Speech" web:http://nobelprize.org/nobel_prizes/chemistry/laureates/1970/leloir-speech.html
  14. ^ Valeria Roman, "A cien años del nacimiento de Luis Federico Leloir" web:http://www.clarin.com/diario/2006/08/27/sociedad/s-01259864.htm
  15. ^ Comodoro Rivadavia. Luis Federico Leloir. Chubut Argentina. Retrieved on 2007-03-19.
  16. ^ Mario Bunge, "Luis F. Leloir" web:http://www.clubdelprogreso.com/index.php?sec=04_05&sid=43&id=2513
  17. ^ World of Scientific Discovery, Thomas Gale, Thomson Corporation, 2005-2006
  18. ^ Valeria Roman, "A cien años del nacimiento de Luis Federico Leloir" web:http://www.clarin.com/diario/2006/08/27/sociedad/s-01259864.htm
  19. ^ Valeria Roman, "A cien años del nacimiento de Luis Federico Leloir" web:http://www.clarin.com/diario/2006/08/27/sociedad/s-01259864.htm
  20. ^ Ariel Barrios Medina, "Luis Federico Leloir (1906-1987): un esbozo biográfico" web: http://www.houssay.org.ar/hh/bio/leloir.htm
  21. ^ Instituto Leloir, web:http://www.leloir.org.ar/Paginas/Institute.htm

2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the Anno Domini era. ... March 19 is the 78th day of the year in the Gregorian calendar (79th in leap years). ... 2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the Anno Domini era. ... March 19 is the 78th day of the year in the Gregorian calendar (79th in leap years). ...

Bibliography

  • Lorenzano, Julio Cesar. Por los caminos de Leloir. Editorial Biblos; 1a edition, July 1994. ISBN 9-5078-6063-0
  • Zuberbuhler de Leloir, Amelia. Retrato personal de Leloir. Vol. 8, No. 25, pp. 45-46, 1983.
  • Nachón, Carlos Alberto. Luis Federico Leloir: ensayo de una biografía. Bank Foundation of Boston, 1994.

See also

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The Nobel Prizes (Swedish: ) are awards in Physics, Chemistry, Literature, Peace, Physiology or Medicine and Economics. ... The Universidad de Buenos Aires (UBA) is the largest university in Argentina, founded on August 12, 1821 in the city of Buenos Aires. ... Bernardo Alberto Houssay (April 10, 1887–September 21, 1971) was an Argentinian physiologist who received (with Carl and Gerty Cori) the 1947 Nobel Prize for Physiology or Medicine for his discovery of the role played by pituitary hormones in regulating the amount of blood sugar (glucose) in animals. ... Galactosemia is a rare genetic metabolic disorder which affects an individuals ability to properly digest the sugar galactose. ... Image File history File links Commons-logo. ... The Wikimedia Commons (also called Wikicommons) is a repository of free content images, sound and other multimedia files. ...

External links

Nobel Laureate in Chemistry

Preceded by
Derek Harold Richard Barton
and Odd Hassel
Nobel Prize in Chemistry
1970
Succeeded by
Gerhard Herzberg
Persondata
NAME Leloir, Luis Federico
ALTERNATIVE NAMES
SHORT DESCRIPTION Argentine biochemist
DATE OF BIRTH 1906-9-6
PLACE OF BIRTH Paris, France
DATE OF DEATH 1987-12-2
PLACE OF DEATH Buenos Aires, Argentina

City flag City coat of arms Motto: Fluctuat nec mergitur (Latin: Tossed by the waves, she does not sink) Paris Eiffel tower as seen from the esplanade du Trocadéro. ... For other uses, see Buenos Aires (disambiguation). ...


  Results from FactBites:
 
Informat.io on Luis Federico Leloir (249 words)
Luis Federico Leloir (September 6, 1906 – December 2, 1987) was a biochemist born in Paris but who lived all his life in Argentina.
Leloir was promptly given the Premio de la Sociedad Científica Argentina, one of few to receive such a prize in a country in which he was a foreigner.
Leloir died in Buenos Aires in 1987 and was interred in La Recoleta Cemetery.
  More results at FactBites »

 
 

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