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Encyclopedia > Loviride

Loveride was an antiviral drug manufactured by Janssen (now part of Janssen-Cilag) that is active against HIV. Loveride was a NNRTI that entered phase III clinical trials in the late 1990's but failed to gain marketing approval because of poor potency. It is of clinical significance only in those patients who were enrolled in clinical trials to evaluate Loveride (e.g., CAESAR and AVANTI), because in those trials Loveride was often given alone and with no companion drug, leading to a high probablity of developing reverse transcriptase mutations such as K103N which result in cross-class resistance to all NNRTI's. Janssen may refer to: Zacharias Janssen (1580–1638), a Dutch spectacle-maker; invented a compound microscope. ... Janssen-Cilag, a Johnson & Johnson subsidiary, was founded in the early nineties by joining the marketing organizations of Cilag and Janssen Pharmaceutica. ... Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. ... Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection. ... In biochemistry, a reverse transcriptase, also known as RNA-directed DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into double-stranded DNA. Normal transcription involves the synthesis of RNA from DNA, hence reverse transcription is the reverse of this, as it synthesises DNA from RNA. Reverse...


Synonyms

  • Loveride
  • R089439

External sites

  • aidsmap



Antivirals (primarily J05A, also S01AD and D06BB) edit
Anti-herpesvirus agents   Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents Amantadine, Arbidol, Oseltamivir, Peramivir, Rimantadine, Zanamivir
 
Antiretroviral drugs   NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
NtRTIs   Tenofovir
NNRTIs   Efavirenz, Delavirdine, Nevirapine, Loviride
PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
Fusion inhibitors Enfuvirtide
 
Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine, Interferon, Podophyllotoxin, Ribavirin, Viramidine

 
 

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