The shorthand t(A;B)(p1;q2) is used to denote a translocation between chromosome A and chromosome B. The information in the second set of parentheses, when given, gives the precise location within the chromosome for chromosomes A and B respectively—with p indicating the short arm of the chromosome, q indicating the long arm, and the numbers after p or q referes to regions, bands and subbands seen when staining the chromosomes under microscope. Figure 1: Chromosome. ...
Anaplastic large cell lymphoma (ALCL) is a type of non_Hodgkin lymphoma that features in the World Health Organisation (WHO) classification of lymphomas. ... Burkitts lymphoma is a type of cancer that is associated with the Epstein-Barr virus, also the cause of mononucleosis as well as other cancers. ... c-Myc is a mammalian transcription factor belonging to the bHLH (basic Helix Loop Helix)_Leucine Zipper family. ... Philadelphia chromosome or Philadelphia translocation is a specific genetic, chromosomal abnormality that is associated with chronic myelogenous leukemia (CML) and involves an exchange of material between chromosomes 9 and 22. ... Chronic myelogenous leukemia (or CML) is a form of chronic leukemia characterised by increased production of myeloid cells in the bone marrow. ... Acute lymphoblastic leukaemia (ALL), also known as acute lymphocytic leukaemia, is a cancer of the white blood cells, characterised by the overproduction and continuous multiplication of malignant and immature white blood cells (referred to as lymphoblasts) in the bone marrow. ... X-Ray of a child with Ewings sarcoma of the tibia Ewings sarcoma is the common name for primitive neuroectodermal tumor. ... Follicular lymphoma (FL) is the most common of the indolent non-Hodgkins lymphomas. ... B cell lymphoma (Bcl)-2 is a mammalian protein family whose members govern mitochondrial membrane permeabilisation (MMP), a key event in apoptosis. ... Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm of the dermis layer of the skin, and is classified as a sarcoma. ... Acute myelogenous leukemia (AML), also known as acute myeloid leukemia, is a cancer of the myeloid line of white blood cells. ... Acute myelogenous leukemia (AML), also known as acute myeloid leukemia, is a cancer of the myeloid line of blood cells. ... A sarcoma is a cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. ...
Category: Genetics Philadelphia chromosome or Philadelphia translocation is a specific genetic, chromosomal abnormality that is associated with chronic myelogenous leukemia (CML) and involves an exchange of material between chromosomes 9 and 22. ... Robertsonian translocations are a common form of chromosomal rearrangement, which occurs in the five acrocentric human chromosome pairs, namely 13, 14, 15, 21, and 22. ...
In meiosis, the pairs of chromosomes are supposed to split up and go to different spots in the dividing cell; this event is called "disjunction." However, occasionally one pair doesn't divide, and the whole pair goes to one spot.
The 21st chromosome may actually hold 200 to 250 genes (being the smallest chromosome in the body in terms of total number of genes); but it's estimated that only a small percentage of those may eventually be involved in producing the features of Down syndrome.
Because of the small size of the 21st chromosome and its association with Down syndrome, it is the second-most heavily mapped human chromosome.
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