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Encyclopedia > Knockdown

A gene knockdown, is a genetically modified organism that carries one or more genes in its chromosomes that has been made less active or had its "expression" reduced. So far such organisms have been engineered chiefly for research purposes. Also known as knockdown organisms or simply knockdowns, their most direct use is for learning about a gene that has been sequenced, but has an unknown or incompletely known function. Researchers draw inferences from how the knockdown differs from individuals in which the gene of interest has not been made inoperative. Knockdown is also the process of creating such an organism, as in "knocking down a gene."

A popular method of knocking down the expression of a gene is through supression of translation using "small interfering RNA."

Compare: gene knockout

  Results from FactBites:
YOJOE.COM | Knockdown (243 words)
Knockdown was first released carded invidually as part of the Battleforce 2000 subset of G.I.Joe at the very end of the sixth series (1987).
Knockdown came with a gold helmet and a silver "experimental ground-to-air pistol".
Knockdown's head was later repainted and used to create Super Trooper, and Rapid Fire.
Knockdown - GuildWiki (1011 words)
knockdown is an effect, usually inflicted by an enemy, during which a character cannot move, attack, or activate skills aside from those with instant activations (such as stances or shouts).
A Knockdown is indicated by the knocked down character falling down to the ground.
On the flip side, skills that cause knockdowns are usually slow to activate, are conditional, or cause exhaustion (or some combination of the three).
  More results at FactBites »



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