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Encyclopedia > JC polyomavirus
JC polyomavirus
Scientific classification
Domain: Virus
(unranked) dsDNA viruses
Family: Polyomaviridae
Genus: Polyomavirus
Species: JC polyomavirus

JC virus or JC polyomavirus is a type of human polyomavirus, genetically similar to BK virus and SV40. It was discovered in 1971 and named after the initials of the person in whom it was found, a patient with progressive multifocal leukoencephalopathy.

The virus is very common in the general population, infecting 70 to 90 percent of humans. Initial infection, which may be through the respiratory tract or orally, produces no symptoms; the virus usually remains latent in the respiratory system and/or kidneys, and can also infect the central nervous system and gastrointestinal tract. Normally, reactivation of the virus will occur only if the patient is immunodeficient, as in AIDS, or immunosuppressed, as in organ transplant patients. If the virus is reactivated, it can attack the kidneys, causing cystitis and ureteral stenosis, or the brain, causing the fatal PML.

Studies since 2000 have found JC virus in malignant colon tumors and suggested that the virus may be linked to colon cancer.

  Results from FactBites:
Polyomavirus - Wikipedia, the free encyclopedia (295 words)
Polyomavirus is the sole genus of viruses within the family Polyomaviridae.
There are two polyomaviruses found in humans: JC virus, which can infect the respiratory system, kidneys, or brain (sometimes causing the fatal progressive multifocal leukoencephalopathy in the latter case), and BK virus, which produces a mild respiratory infection and can affect the kidneys of immunosuppressed transplant patients.
An avian polyomavirus sometimes referred to as the Budgerigar fledgling disease virus is a frequent cause of death among caged birds.
Polyomaviruses, JC Virus, BK Virus (1487 words)
JC was first isolated from the brain from a patient suffering from Hodgkin's disease, and suffering from PML.
Polyomavirus replication in permissive cells can be detected by observing CPE or plaque production, by identifying virus particles in cell or culture fluid by EM, by detecting virus antigens using IF, or by observing haemagglutination.
JC and BK viruses are ubiquitous throughout the world, and the 2 viruses circulate independently.
  More results at FactBites »



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