FACTOID # 22: South Dakota has the highest employment ratio in America, but the lowest median earnings of full-time male employees.
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Action: Relaxation of smooth muscle of venous and arterial vasculature.

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Transdermal medication system for isosorbide dinitrate - Patent 4293565 (3047 words)
These ranges guarantee that first the concentration of dissolved isosorbide dinitrate in the preparation is high enough in order to achieve a satisfactory resportion rate and that second the amount of undissolved isosorbide dinitrate in the preparation is great enough in order to achieve a long time effect.
After a (nominal dosage) of 100 mg isosorbide dinitrate (based on the preparation according to Example 1) had been applied to human skin the average concentrations of the active ingredient were 1 to 2 ng/ml (nanogram/milliliter--a nanogram is 1 gram.times.10.sup.-9) during the first one and a half hours and reached 6.2 ng/ml after 6 hours.
In the case of a sublingual application of a tablet with 5 mg isosorbide dinitrate the highest level of the active ingredient in the plasma (15.9 ng/ml) was reached after 0.5 hours; then the level dropped with a half-life period of about 50 minutes.
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