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Encyclopedia > Immunotherapy

The term immunotherapy incorporates an array of strategies of treatment based upon the concept of modulating the immune system to achieve a prophylactic and/or therapeutic goal. Image File history File links Acap. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ... Prophylaxis refers to any medical or public health procedure whose purpose is to prevent, rather than treat or cure, disease. ... Immunosuppression is the medical suppression of the immune system. ...

Contents

Activation

Cancer

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors. BCG immunotherapy for early stage (non-invasive) bladder cancer utilizes instillation of attenuated live bacteria into the bladder, and is effective in preventing recurrence in up to 2/3 of cases. Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which is an interferon producer causing the patients own killer T cells to destroy warts, actinic keratoses, basal cell cancer, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma. Injection immunotherapy uses mumps, candida or trichophytin antigen injections to treat warts (HPV induced tumors). Cancer Immunotherapy is the use of monoclonal antibodies (-mab) to specifically target cells. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ... An apparatus (4-5 cm length, with nine short needles) used for BCG vaccination in Japan. ... Bladder cancer refers to any of several types of malignant growths of the urinary bladder. ... Imiquimod (INN, marketed by 3M under the trade name Aldaraâ„¢) is a prescription medication used to treat certain diseases of the skin, including skin cancer (basal cell carcinoma, Bowens disease, superficial squamous cell carcinoma, some superfical malignant melanomas and actinic keratosis) as well as genital warts. ...


Dendritic cell based immunotherapy

This utilizes dendritic cells to activate a cytotoxic response towards an antigen. Dendritic cells, an antigen presenting cell, are harvested from a patient. These cells are then either pulsed with an antigen or transfected with a viral vector. The activated dendritic cells are then placed back into the patient; these cells then present the antigens to effector lymphocytes (CD4+ T cells, CD8+ T cells, and in specialised dendritic cells, B cells also). This intitiates a cytotoxic response to occur against these antigens and anything that may present these antigens. One use for this therapy is in cancer immunotherapy. Tumor Antigens are presented to dendritic cells which cause the immune system to target these antigens, which are often expressed on cancerous cells. Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... Cytotoxicity is the quality of being poisonous to cells. ... This article does not cite any references or sources. ... An antigen presenting cell (APC) is a cell that displays foreign antigen complexed with MHC on its surface. ... Viral vectors are a tool commonly used by biologists to deliver genetic material into cells inside a living organism or cultured in vitro. ...


T cell based adoptive immunotherapy

This therapy uses T cell-based cytotoxic responses to attack cancer. In brief, T cells that have a natural or genetically engineered reactivity to a patients' cancer are expanded in vitro using a variety of means and then adoptively transferred into a cancer patient. T cells with a natural occurring reactivity to a patients cancer can be found in infiltrated in that patients' own tumors. The tumor is harvested, and these tumor infiltrating lymphocytes (TIL) are expanded in vitro using high concentrations of interluekin-2 (IL-2), anti-CD3 and allo-reactive feeders. These T cells are then transferred back into the patient along with exogenous administration of IL-2. Thus far, a 51% objective response rate has been observed; in some patients, tumors shrank to nondetectable size. In the case of engineered T cells, T cell receptors (TCR) that have been identified to have reactivity against tumor associated antigens are cloned into a replication incompetent virus that is capable of genomic integration. A patients own lymphocytes are exposed to these viruses and then expanded non-specifically or stimulated using the engineered TCR. The cells are then transferred back into the patient. This therapy has been demonstrated to result in objective clinical responses in patients with refractory stage IV cancer. The Surgery Branch of the National Cancer Institute (Bethesda, Maryland) is actively investigating this form of cancer treatment for patients suffereing aggressive melanomas.


Vaccination

Anti-microbial immunotherapy, which includes vaccination, involves activating the immune system to respond to an infectious agent. An antimicrobial is a substance that kills or slows the growth of microbes like bacteria (antibacterial activity), fungi (antifungal activity), viruses (antiviral activity), or parasites (antiparasitic activity). ... Vaccination is the process of administering pathogens that cant reproduce (due to being weakened or dead) to a healthy person or animal, with the intent of conferring immunity against a targeted form of a related disease agent. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ...


Suppression

Immune suppression dampens an abnormal immune response in autoimmune diseases or reduces a normal immune response to prevent rejection of transplanted organs or cells. Immunosuppression is the medical suppression of the immune system. ... A request has been made on Wikipedia for this article to be deleted in accordance with the deletion policy. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... A request has been made on Wikipedia for this article to be deleted in accordance with the deletion policy. ... Transplant rejection occurs when the immune system of the recipient of a transplant attacks the transplanted organ or tissue. ... An organ transplant is the transplantation of an organ (or part of one) from one body to another, for the purpose of replacing the recipients damaged or failing organ with a working one from the donor. ...


Immune tolerance

Immune tolerance is the process by which the body naturally does not launch an immune system attack on its own tissues. Immune tolerance therapies seeks to reset the immune system so that the body stops mistakenly attacking its own organs or cells in autoimmune disease or accepts foreign tissue in organ transplantation.[1] A brief treatment should then reduce or eliminate the need for life-long immunosuppression and the chances of attendant side effects, in the case of transplantation, or preserve the body's own function, at least in part, in cases of type 1 diabetes or other autoimmune disorders. Immune or immunological tolerance is the process by which the immune system does not attack an antigen. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... An organ transplant is the transplantation of an organ (or part of one) from one body to another, for the purpose of replacing the recipients damaged or failing organ with a working one from the donor. ...

Allergies

Main article: Allergy immunotherapy

Immunotherapy is also used to treat allergies. While other allergy treatments (such as antihistamines or corticosteroids) treat only the symptoms of allergic disease, immunotherapy is the only available treatment that can modify the natural course of the allergic disease, by reducing sensitivity to allergens. Hyposensitization (or allergy desensitization) is a form of immunotherapy where the patient is gradually vaccinated against progressively larger doses of the allergen in question. ... An allergy is an abnormal, acquired sensitivity to a given substance, including pollen, drugs, or numerous environmental triggers. ... An antihistamine is a drug which serves to reduce or eliminate effects mediated by histamine, an endogenous chemical mediator released during allergic reactions, through action at the histamine receptor. ... In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... An allergen is any substance (antigen), most often eaten or inhaled, that is recognized by the immune system and causes an allergic reaction. ...


A three-to-five-year individually tailored regimen of injections may result in long-term benefits. Recent research suggests that patients who complete immunotherapy may continue to see benefits for years to come.[2] Immunotherapy does not work for everyone and is only partly effective in some people, but it offers allergy sufferers the chance to eventually reduce or stop symptomatic/rescue medication.


The therapy is indicated for people who are extremely allergic or who cannot avoid specific allergens. For example, they may not be able to live a normal life and completely avoid pollen, dust mites, mould spores, pet dander, insect venom, and certain other common triggers of allergic reactions. Immunotherapy is generally not indicated for food or medicinal allergies. Immunotherapy is typically individually tailored and administered by an allergist (allergologist). Injection schedules are available in some healthcare systems and can be prescribed by family physicians. This therapy is particularly useful for people with allergic rhinitis or asthma. An allergen is any substance (antigen), most often eaten or inhaled, that is recognized by the immune system and causes an allergic reaction. ... For the play, see Hay Fever. ...


The therapy is particularly likely to be successful if it begins early in life or soon after the allergy develops for the first time. Immunotherapy involves a series of injections (shots) given regularly for several years by a specialist in a hospital clinic. In the past, this was called a serum, but this is an incorrect name. Most allergists now call this mixture an allergy extract. The first shots contain very tiny amounts of the allergen or antigen to which you are allergic. With progressively increasing dosages over time, your body will adjust to the allergen and become less sensitive to it. This process is called desensitization. A recently approved sublingual tablet (Grazax), containing a grass pollen extract, is similarly effective, with few side effects, and can be self-administered at home, including by those patients who also suffer from allergic asthma, a condition which precludes the use of injection-based desensitisation. To read more about this topic, see: allergy and hyposensitization. An allergy is an abnormal, acquired sensitivity to a given substance, including pollen, drugs, or numerous environmental triggers. ... Hyposensitization (or allergy desensitization) is a form of immunotherapy where the patient is gradually vaccinated against progressively larger doses of the allergen in question. ...


See Also

The American Cancer Society (ACS) is a medical organization with a corporate attitude in the United States. ...

Footnotes

  1. ^ Rotrosen D, Matthews JB, Bluestone JA (2002). "The immune tolerance network: a new paradigm for developing tolerance-inducing therapies". J. Allergy Clin. Immunol. 110 (1): 17-23. PMID 12110811. 
  2. ^ Durham SR, Walker SM, Varga EM, et al (1999). "Long-term clinical efficacy of grass-pollen immunotherapy". N. Engl. J. Med. 341 (7): 468-75. PMID 10441602. 

  Results from FactBites:
 
InteliHealth: (1305 words)
Immunotherapy is a relatively new type of treatment that uses the body's own immune defenses to attack cancer.
Some types of immunotherapy are also used to treat noncancerous conditions such as rheumatoid arthritis, Crohn's disease and multiple sclerosis.
Immunotherapy is a rapidly evolving area of therapy, and much of the work being done is still experimental.
Immunotherapy - Wikipedia, the free encyclopedia (526 words)
Immunotherapy is a form of medical treatment based upon the concept of modulating the immune system to achieve a therapeutic goal.
Topical immunotherapy utilizes a immune enhancement cream (imiquimod) which is an interferon producer causing the patients own killer T cells to destroy warts, actinic keratoses, basal cell cancer, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma.
Immunotherapy is typically individually tailored and administered by an allergist (allergologist), although standardized immunotherapy serums and injection schedules are available in some healthcare systems and can be prescribed by family physicians.
  More results at FactBites »

 
 

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