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Encyclopedia > Hydroxypethidine
Hydroxypethidine
Systematic (IUPAC) name
Ethyl 4-(3-hydroxyphenyl)-1-methyl-piperidine-4-carboxylate
Identifiers
CAS number 468-56-4
ATC code  ?
PubChem 61120
Chemical data
Formula C15H21NO3 
Mol. mass 263.332 g/mol
Synonyms Hydroxypethidine, Bemidone
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules. ... This article does not cite its references or sources. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... Synonyms can be nouns, adverbs or adjectives, as long as both members of the pair are the same part of speech. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of pethidine (meperidine). Hydroxypethidine is considered more potent and effective an analgesic than pethidine, but less potent than ketobemidone. [1] The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... This article needs additional references or sources to facilitate its verification. ... This article or section does not adequately cite its references or sources. ... An analog is in chemistry a chemical closely related to another usually sharing the same nucleus. ... Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolargan® (in Poland);[1] Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ... Ketobemidone structure Ketobemidone is a powerful opioid analgesic. ...


Hydroxypethidine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening. An itch (Latin: pruritus) is a sensation felt on an area of skin that makes a person or animal want to scratch it. ... For the Beck song, see Nausea (song). ... In medicine, hypoventilation exists when ventilation is inadequate to perform gas exchange. ...


References

  1. ^ Isbell Harris. The addiction liability of some analogues of meperidine. Journal of Pharmacology And Experimental Therapeutics, 1949; 97(2): 182-190

  Results from FactBites:
 
UNODC - Bulletin on Narcotics - 1952 Issue 4 - 004 (5349 words)
The synthetics which may be encountered as illicit seizures are: methadone, pipidone, phenadoxone; pethidine, hydroxypethidine, ketobemidone, alphaprodine; methorphinan and metopon.
As far as the authors have been able to learn, for four of these nine narcotics there has been no previous publication of any article dealing particularly with their identification as it may have to be made by narcotic or drug chemists.
The reagent gives crystals with cocaine and hydroxypethidine, which are closely related to alphaprodine in structure as well as having about the same basic strength.
  More results at FactBites »

 
 

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