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Encyclopedia > Human serum albumin
It has been suggested that this article or section be merged into serum albumin. (Discuss)
Human serum albumin chemical structure
The structure of human serum albumin complexed with 6 palmitic acid molecules
(from PDB 1E7H)
Human serum albumin
Identifiers
Symbol(s) ALB
Entrez 213
OMIM 103600
RefSeq NM_000477
UniProt P02768
PDB {{{PDB}}}
Other data
EC number [1]
Locus Chr. 4 q13.3

Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. The reference range for albumin concentrations in blood is 30 to 50 g/L (3.0 to 5.0 g/dL). It has a serum half-life of approximately 20 days. It has a molecular mass of 67 kDa. Wikipedia does not have an article with this exact name. ... You may be looking for albumen, or egg white. ... Image File history File links ALB_structure. ... Palmitic acid, also called hexadecanoic acid, is one of the most common saturated fatty acids found in animals and plants. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Trinomial name Homo sapiens sapiens Linnaeus, 1758 Humans, or human beings, are animals biologically classified as bipedal primates belonging to the mammalian genus Homo, in particular to its only extant species, Homo sapiens (Latin for wise man or knowing man), under the family Hominidae (the great apes). ... Blood plasma is the liquid component of blood, in which the blood cells are suspended. ... The liver is the largest internal organ of the human body. ... In health-related fields, a reference range is a set of values of some measurement that a physician or other health professional can use to interpret a set of results for a particular patient. ... The molecular mass (abbreviated MM) of a substance, called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ...

Contents


Hypoalbuminemia

Low blood albumin levels can be caused by malnutrition, malabsorption, liver disease, nephrotic syndrome, neoplasia or pregnancy. Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Malnutrition is a general term for the medical condition caused by an improper or insufficient (undernourished) diet. ... Neoplasia (literally: new growth) is abnormal, disorganized growth in a tissue or organ, usually forming a distinct mass. ... Pregnancy is the carrying of one or more embryos or fetuses by female mammals, including humans, inside their bodies. ...


Hyperalbuminemia

Typically is a sign of severe dehydration.


Amino Acid Sequence

The approximate sequence of human serum albumin is:


MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV AASQAALGL


Where the italicized first 24 amino acids are signal and propeptide portions not observed in the transcribed and tranported protein but present in the gene. There are 609 amino acids in this sequence with only 585 amino acids in the final product observed in the blood.


External links

  • Human Albumin information in the Swis-Prot/TrEMBL database
  • Human Serum Albumin on the Human Protein Reference Database

The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ...

See also


 
 

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