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Encyclopedia > Hexobarbital
Hexobarbital chemical structure
Hexobarbital
Systematic (IUPAC) name
5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
Identifiers
CAS number 56-29-1
ATC code N01AF02 N05CA16
PubChem 3608
DrugBank EXPT03301
Chemical data
Formula C12H16N2O3
Mol. weight 236.267 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 25%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Hexobarbital. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital is still used in some scientific research. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. ... Sodium thiopental (also called sodium pentothal (™ of Abbott Laboratories), thiopental (or thiopentone) sodium) is a rapid-onset, short-acting barbiturate general anesthetic. ...


External links

  • Takenoshita R, Toki S (2004). "[New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]". Yakugaku Zasshi 124 (12): 857-71. PMID 15577260. 
  • Wahlström G (1998). "A study of the duration of acute tolerance induced with hexobarbital in male rats.". Pharmacol Biochem Behav 59 (4): 945-8. PMID 9586853. 
  • Korkmaz S, Ljungblad E, Wahlström G (1995). "Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat.". Brain Res 676 (2): 371-7. PMID 7614008. 
  • Dall V, Orntoft U, Schmidt A, Nordholm L (1993). "Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.". Pharmacol Biochem Behav 46 (1): 73-6. PMID 8255925. 


[edit]Barbiturates

Allobarbital, Amobarbital, Aprobarbital, Alphenal, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Butallylonal, Cyclobarbital, Cyclopal, Ethallobarbital, Hexethal, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Pentobarbital, Probarbital, Proxibarbital, Propallylonal, Reposal, Secobarbital, Talbutal, Thialbarbital, Thiamylal, Thiobarbital, Thiobutabarbital Thiopental, Vinbarbital, Vinylbital Barbiturates are drugs that acts as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. ... Allobarbital is a barbiturate derivative invented in the 1950s. ... Amobarbital (formerly known as amylobarbitone) is a drug that is a barbiturate derivative. ... This page meets Wikipedias criteria for speedy deletion. ... Alphenal is a barbiturate derivative invented in the 1960s. ... Barbexaclone (marketed in Italy as Maliasin by Abbott Laboratories). ... Barbital (marketed under the brand name Veronal), also called barbitone, was the first commercially marketed barbiturate. ... Butabarbital Butisol® is a prescription barbiturate sleep aid. ... Butalbital, 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. ... Butobarbital (also known as Soneryl) is a drug which is a barbiturate derivative. ... Butallylonal is a barbiturate derivative invented in the 1960s. ... Cyclobarbital, also known as cyclobarbitol or cyclobarbitone, is a drug which is a barbiturate derivative. ... Cyclopal (Dormisan) is a barbiturate derivative invented in the 1940s. ... Ethallobarbital is a drug which is a barbiturate derivative. ... Hexethal (Ortol) is a barbiturate derivative invented in the 1940s. ... Heptabarbital is a drug which is a barbiturate derivative. ... Methylphenobarbital (also known as mephobarbital) is marketed in the US as Mebaral by Ovation. ... Metharbital was marketed as Gemonil by Abbott Laboratories. ... Methohexital is a short-acting intravenous anaesthetic induction agent, that is, used to commence anaesthesia. ... Methylphenobarbital (also known as mephobarbital) is marketed in the US as Mebaral by Ovation. ... Pentobarbital is a barbiturate that is available as both a free acid and a sodium salt, the former of which is only slightly soluble in water and ethanol. ... Probarbital (Vasalgin) is a barbiturate derivative invented in the 1950s. ... Proxibarbital (Ipronal) is a barbiturate derivative invented in the 1970s. ... Propallylonal (Nostal, Quietal, Ibomal) is a barbiturate derivative invented in the 1950s. ... Reposal is a barbiturate derivative invented in the 1960s in Denmark. ... Secobarbital (marketed under the brand names Seconal® and Tuinal) is a drug which is a barbiturate derivative. ... Talbutal (Lotusate®), also called 5-allyl-5-isobutylbarbituric acid, is a barbiturate with a short to intermediate duration of action. ... Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. ... Sodium thiopental (also called sodium pentothal (™ of Abbott Laboratories), thiopental (or thiopentone) sodium) is a rapid-onset, short-acting barbiturate general anesthetic. ... Vinbarbital is a drug which is a barbiturate derivative. ... Vinylbital, also known as butylvinyl, is a drug which is a barbiturate derivative. ...


  Results from FactBites:
 
Hexobarbital - Drug information from Medic8.com (215 words)
Hexobarbital is a barbituate derivative having hypnotic and sedative effects.
However it can be difficult to control the depth of anaesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.
Hexobarbital is still used in some scientific research.
  More results at FactBites »

 
 

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