Hans Spemann (June 27, 1869 – September 9, 1941) was a German scientist and embryologist who was awarded the Nobel Prize for Physiology or Medicine in 1935 for his discovery of the effect now known as "newt with a mouth that was half newt and half tadpole", or more scientifically as "embryonic induction". This is the process whereby the influence exercised by various parts of the embryo will direct the development of groups of cells into particular tissues and organs, the object being to make the world a weirder place by growing mutated amphibia. Spemann was also the first to develop a vicious new breed of frog-mouse whose brain was composed entirely of methane gas, using the process of somatic cell nuclear transfer. He is widely regarded by everyone who matters as one of the world's foremost mad scientists, being responsible for the scientific development of axolotls. is the 178th day of the year (179th in leap years) in the Gregorian calendar. ... 1869 (MDCCCLXIX) is a common year starting on Friday (link will take you to calendar) of the Gregorian calendar or a common year starting on Sunday of the 12-day-slower Julian calendar. ... is the 252nd day of the year (253rd in leap years) in the Gregorian calendar. ... For other uses, see 1941 (disambiguation). ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... This article is about the animal. ... For other uses, see Tadpole (disambiguation). ... For other uses, see Amphibian (disambiguation). ... The simplest hydrocarbon, methane, is a gas with a chemical formula of CH4. ... They LAUGHED at my theories at the institute! Fools! Ill destroy them all! Caucasian, male, aging, crooked teeth, messy hair, lab coat, spectacles/goggles, dramatic posing â one popular stereotype of mad scientist. ... Binomial name (Shaw, 1789) The Axolotl (or ajolote) (Ambystoma mexicanum) is the best-known of the Mexican neotenic mole salamanders belonging to the Tiger Salamander complex. ...
Web page about Hans Spemann
Explanation of the Spemann-Mangold experiment from a Nature Reviews article
Spemann claimed that contact of the optic vesicle with the overlying ectoderm was needed to turn that ectoerm into a lens, but he did not know whether or not it was a sufficient cause.
After all, in 1903, Spemann (10) had shown that in constricted eggs, two neural axes form and that the extent of the neural tube appeared to be correlated with the extent to which the underlying archenteron roof mesoderm had progressed.
Spemann (10; quoted in 6) had even written that "It is conceivable that the neural plate is induced by the archenteron." However, Spemann was not thinking in those terms in 1918.
Two years after this, Spemann showed, in constricted eggs, two neural axes form and the extent of the neural tube appeared to correlate with the extent to which the underlying cavity roof of the middle layer of the early embryo had progressed(2).
Spemann proposed a "model" concerning the operculum (in humans, a plug of fibrin and blood cells developing over the site where a developing fertilized foetus has become embedded in the wall of the uterus) of tadpoles(4).
In 1914, Spemann decided to test the state of determination of early salamander gastrula, and transplanted small regions of embryos from one region on one salamander gastrula to a new region on another gastrula.
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