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Encyclopedia > HGH controversies
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There are many controversies around the claims, products, and businesses related to the use of growth hormone as an anti-aging therapy. Most of this controversy falls into two categories: Image File history File links Unbalanced_scales. ... Image File history File links Information_icon. ... Growth hormone (GH or somatotropin) is a 191-amino acid, single chain polypeptide hormone which is synthesised, stored and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland, which stimulates growth and cell reproduction in humans and other animals. ... Life extension refers to an increase in maximum or average lifespan, especially in humans, by slowing down or reversing the processes of aging. ...

  1. Claims of exaggerated, misleading, or unfounded assertions that real growth hormone treatment slows or reverses the effects of aging
  2. The sale of products that fraudulently or misleadingly purport to be growth hormone or to increase the user's own secretion of natural human growth hormone to a beneficial degree.

Following a study in 1990 by Rudman[1] which showed fat loss, muscle mass increase and maintenance of healthy skin from the administration of growth hormone in elderly men, there has been a burgeoning industry surrounding the sale and administration of GH and its purported anti-aging effects. Growth hormone (GH) is a protein hormone secreted by the pituitary gland which stimulates growth and cell reproduction. ... Ageing or aging is the process of getting older. ...

As is common with such therapies, the literature is now dominated by advocacy from pharmaceutical companies. Solid medical evidence is harder to find, and appears to indicate mixed results. It is likely that there is some advantage, but it is also evident that benefits are being exaggerated by some for commercial gain[2].

Some of the side effects reportedly seen in previously healthy mature patients after taking HGH include:

Chronic use of hGH is not well studied, except when used in children for acute growth deficiencies. A long term increase in colon cancer and Hodgkin's Disease has been observed in these cases.[4] Edema (American English) or oedema (British English), formerly known as dropsy or hydropsy, is swelling of any organ or tissue due to accumulation of excess lymph fluid, without an increase of the number of cells in the affected tissue. ... Arthralgia is a term used to describe pain in the joints. ... It has been suggested that Carpal tunnel be merged into this article or section. ... For other forms of hypertension, see Hypertension (disambiguation). ... This article is about the disease that features high blood sugar. ... Gynecomastia (pronounced: GUY-nuh-ko-MASS-tee-uh) is the development of abnormally large mammary glands in males resulting in breast enlargement, which can sometimes cause secretion of milk. ... Cross section of the breast of a human female. ... Diagram of the stomach, colon, and rectum Colorectal cancer includes cancerous growths in the colon, rectum and appendix. ...


  1. ^ Rudman D, Feller AG, Nagraj HS, et al. "Effect of human growth hormone in men over 60 years old," New England Journal of Medicine 323:1–6
  2. ^ “HGH” Pills and Sprays: Human Growth Hype? (PDF). FTC Consumer Alert. Federal Trade Commission (June 2005). Retrieved on 2006-11-19.
  3. ^ a b c d e Liu, H., et al. (2006). "The safety and efficacy of growth hormone in the healthy elderly: A systematic review". Endocrine Society meeting: P3-770.
  4. ^ Sklar CA. Growth hormone treatment: cancer risk. Horm Res. 2004;62 Suppl 3:30-4. Review. PMID 15539796



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