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Encyclopedia > Guaifenesin
Guaifenesin
Systematic (IUPAC) name
3-(2-methoxyphenoxy)propane-1,2-diol
Identifiers
CAS number 93-14-1
ATC code R05CA03
PubChem 3516
DrugBank APRD01005
Chemical data
Formula C10H14O4 
Mol. mass 198.216 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1 hour
Excretion  ?
Therapeutic considerations
Licence data

US Image File history File links Guaifenesin. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Pregnancy cat.

C (US) The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... United States may refer to: Places: United States of America SS United States, the fastest ocean liner ever built. ...

Legal status

OTC (US) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... United States may refer to: Places: United States of America SS United States, the fastest ocean liner ever built. ...

Routes Oral

Guaifenesin (IPA: [gwaɪ ˈfɛ nə sɪn]) (INN) or guaiphenesin (former BAN) is an expectorant drug usually taken orally to assist the expectoration ("bringing up") of phlegm from the airways in acute respiratory tract infections. Similar medicines derived from the guaiac tree were in use as a generic remedy by Native Americans when explorers reached North America in the 1500s, but guaifenesin was first approved by the U.S. Food and Drug Administration (FDA) in 1952. It is sold as pills or syrups under several brand names such as Guai-Aid, GuaiLife, Ethex 208, Humibid, Mucinex, Pseudovent, and Robitussin. It is also included in many over-the-counter cough and cold remedies. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Articles with similar titles include the NATO phonetic alphabet, which has also informally been called the “International Phonetic Alphabet”. For information on how to read IPA transcriptions of English words, see IPA chart for English. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... A British Approved Name (BAN) is the official non-proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia (BP). ... A cough medicine or antitussive is a medication given to people to help them stop coughing. ... It has been suggested that Blockbuster drug be merged into this article or section. ... Phlegm (pronounced ) is sticky fluid secreted by the typhoid membranes of animals. ... The airways are those parts of the respiratory system through which air flows, to get from the external environment to the alveoli. ... Species Six species, including: Guaiacum officinale Guaiacum sanctum Guaiacum, or guajacum, is a genus in the family Zygophyllaceae. ... Native Americans can refer to Native Americans in the United States, natives of the United States only; equivalent to American Indians in some contexts. ... North America North America is a continent [1] in the Earths northern hemisphere and (chiefly) western hemisphere. ... FDA logo The Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services and is responsible for regulating food, dietary supplements, drugs, biological medical products, blood products, medical devices, radiation-emitting devices, veterinary products, and cosmetics in the United States. ... This article is about brands in marketing. ... Robitussin is a brand of cold and cough medicines produced by Wyeth Consumer Healthcare. ...

Contents

Uses

Treatment of asthma

Guaifenesin is effective in the treatment of the thickened bronchial mucosa characteristic of asthma. It works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing. One may notice a sense of dry mouth when taking this medication. Water consumption is important, not only to help with dry mouth, but also to improve the effectiveness of the drug. A bronchus (plural bronchi, adjective bronchial) is a caliber of airway in the respiratory tract that conducts air into the lungs. ... Mucus is a slippery secretion of the lining of various membranes in the body (mucous membranes). ... Xerostomia is the medical term for a dry mouth due to a lack of saliva. ...


Treatment of coughing

Guaifenesin is frequently combined with dextromethorphan, an antitussive. Under normal circumstances this combination leads to fewer, but more productive coughs. However, in the quantities consumed by recreational users of dextromethorphan, it may cause nausea and vomiting, as well as the formation of stones in the urinary tract (urolithiasis). Moreover, because of concerns about illegal recreational drugs, the government has forced manufacturers of ephedrine to add guaifenesin to over the counter weight loss medications. // Dextromethorphan hydrobromide monohydrate (DM or DXM) is an antitussive drug that is found in many over-the-counter cold and cough preparations. ... A cough medicine is a drug used to treat coughing and related conditions. ... // Dextromethorphan hydrobromide monohydrate (DM or DXM) is an antitussive drug that is found in many over-the-counter cold and cough preparations. ... Kidney stones are solid accretions (crystals) of dissolved minerals in urine found inside the kidneys or ureters. ...


Treatment of fibromyalgia

Because of its uricosuric effect, guaifenesin was chosen for the experimental guaifenesin protocol in the 1990s as a treatment for fibromyalgia, and proponents of the guaifenesin protocol believe that it cures fibromyalgia by removing excess phosphate from the body. A lesser publicized and thus lesser known fact among fibromyalgia sufferers is that guaifenesin has a skeletal muscle relaxant property, and a form of guaifenesin known as guafenesin carbomate is used for this purpose. This may explain some of the symptomatic relief experienced by fibromyalgia sufferers who take guaifenesin. Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. ... Guaifenesin protocol is a popular, experimental, alternative treatment for fibromyalgia proposed in the 1990s by R. Paul St. ... Fibromyalgia (FM or FMS) is a chronic syndrome (constellation of signs and symptoms) characterized by diffuse or specific muscle, joint, or bone pain, fatigue, and a wide range of other symptoms. ...


Muscle relaxant and inhibition of platelet aggregation

Guaifenesin also has other known neurological effects, including an analgesic effect that is related to its action as a skeletal muscle relaxant, and it may inhibit platelet aggregation. Guaifenesin's neurological properties first became known in the late 1940s, and it is still used in veterinary medicine to anesthetize horses being prepared for surgery. When contrasted with other propanediol drugs used for this purpose, guaifenesin has less hemolytic activity (i.e., less destruction of red blood cells) and is more soluble in water. A muscle relaxant is a drug which decreases the tone of a muscle. ... An antiplatelet drug is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. ... Veterinary medicine is the application of medical diagnostic and therapeutic principles to companion, domestic, exotic, wildlife, and production animals. ... horse, see Horse (disambiguation). ...


External links

  • MedlinePlus DrugInfo medmaster-a682494
  • RxList site giving some properties
  • Information from MedicineNet.com
  • RxList information

  Results from FactBites:
 
Guaifenesin Price Info (297 words)
Guaifenesin is a common component of many cold and cough remedies that helps loosen and liquefy mucous.
Guaifenesin is a safe medication that may even be used by children.
Guaifenesin is an FDA-approved medication used to treat respiratory illnesses like coughs and colds, although it is not on the FDA approved list to treat fibromyalgia.
  More results at FactBites »

 
 

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