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Encyclopedia > Growth hormone releasing hormone
Growth hormone releasing hormone
Symbol(s): GHRH, GRF, GHRF
Locus: 20p12 or q11.2-q12
AA: 108 (unproc. precur.)/44 (protein)
Codes: EntrezGene 2691, RefSeq NM_021081, UniProt P01286, OMIM 139190

Growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GRF or GHRF), is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion. GHRH also stimulates the production of GH. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes Slow-Wave Sleep directly (PMID 11924022). Hugo is a masculine name. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 20 is one of the 23 pairs of chromosomes in humans. ... In chemistry, an amino acid is any molecule that contains both amino and carboxylic acid functional groups. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... In chemistry, an amino acid is any molecule that contains both amino and carboxylic acid functional groups. ... Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. ... The arcuate nucleus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. ... In the anatomy of mammals, the hypothalamus is a region of the brain located below the thalamus, forming the major portion of the ventral region of the diencephalon and functioning to regulate certain metabolic processes and other autonomic activities. ... The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ... Growth hormone Growth hormone is a polypeptide hormone synthesised and secreted by the anterior pituitary gland which stimulates growth and cell reproduction in humans and other vertebrate animals. ...


The actions of GHRH are opposed by another hypothalamic hormone, somatostatin, also known as "growth hormone-inhibiting hormone" (GHIH). Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary where it inhibits GH secretion by hyperpolarising the somatotropes. Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH. Somatostatin is a hormone. ...


The amino acid sequence of GHRH is: Peptide sequence or amino acid sequence is the order in which amino acid residues, connected by peptide bonds, lie in the chain. ...


Tyr - Ala - Asp - Ala - Ile - Phe - Thr - Asn - Ser - Tyr - Arg - Lys - Val - Leu - Gly - Glu - Leu - Ser - Ala - Arg - Lys - Leu - Leu - Gln - Asp - Ile - Met - Ser - Arg - Glu - Gln - Gly - Glu - Ser - Asn - Gln - Glu - Arg - Gly - Ala - Arg - Ala - Arg - LeuNH2

Hormones and endocrine glands

Hypothalamus: GnRH - TRH - CRH - GHRH - somatostatin | Posterior pituitary: ADH - oxytocin | Anterior pituitary: GH - ACTH - TSH - LH - FSH - prolactin - MSH A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... An endocrine gland is one of a set of internal organs involved in the secretion of hormones into the blood. ... In the anatomy of mammals, the hypothalamus is a region of the brain located below the thalamus, forming the major portion of the ventral region of the diencephalon and functioning to regulate certain metabolic processes and other autonomic activities. ... Gonadotropin Releasing Hormone (GnRH) is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. ... Thyrotropin-releasing hormone (TRH) is a tripeptide hormone that stimulates the release of TSH and prolactin by the anterior pituitary. ... Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response. ... Somatostatin is a hormone. ... The posterior pituitary (also called the neurohypophysis) comprises the posterior lobe of the pituitary gland and is part of the endocrine system. ... Antidiuretic hormone (ADH), or arginine vasopressin (AVP), is a peptide hormone produced by the hypothalamus, and stored in the posterior part of the pituitary gland. ... Oxytocin is a hormone, found in mammals, which in humans is released mainly after stimulation of the nipples or distention of the vagina and which facilitates birth and breastfeeding. ... The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ... Growth hormone Growth hormone is a polypeptide hormone synthesised and secreted by the anterior pituitary gland which stimulates growth and cell reproduction in humans and other vertebrate animals. ... Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone synthesised (from POMC, pre-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing factor (CRF) released by the hypothalamus. ... Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone synthesised and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ... Luteinizing hormone (LH) is a hormone synthesised and secreted by gonadotropes in the anterior lobe of the pituitary gland. ... Follicle stimulating hormone Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. ... Prolactin is a hormone synthesised and secreted by lactotrope cells in the adenohypophysis (anterior pituitary gland). ... Melanocyte-stimulating hormone (MSH) is a peptide hormone produced by cells in the intermediate lobe of the pituitary gland. ...


Thyroid: T3 and T4 - calcitonin | Parathyroid: PTH | Adrenal medulla: epinephrine - norepinephrine | Adrenal cortex: aldosterone - cortisol | Pancreas: insulin - glucagon | Ovary: estradiol - progesterone - inhibin - activin | Testis: testosterone - AMH | Pineal gland: melatonin The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ... Calcitonin is a a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobranchial body. ... Categories: Anatomy stubs | Endocrine system ... Parathyroid hormone (PTH) is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. ... Grays Fig. ... Epinephrine (INN) or adrenaline (BAN) is a hormone and a neurotransmitter. ... Norepinephrine or noradrenaline is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ... Grays Fig. ... Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ... Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... The pancreas is an organ that serves two functions: exocrine - it produces pancreatic juice containing digestive enzymes. ... The structure of insulin Red: carbon; green: oxygen; blue: nitrogen; pink: sulfur. ... Glucagon ball and stick model Glucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... Estradiol (17-beta estradiol) is a sex hormone. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Human male anatomy The testicles, known medically as testes (singular testis), are the male generative glands in animals. ... Testosterone is a steroid hormone from the androgen group. ... Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that inhibits the development of the Müllerian ducts in a male embryo. ... This article does not cite its references or sources. ... Melatonin, 5-methoxy-N-acetyltryptamine, is a hormone produced by pinealocytes in the pineal gland (located in the brain) and also by the retina and GI tract. ...


Stomach: gastrin | Duodenum: CCK - GIP - secretin - motilin - VIP | Ileum: enteroglucagon-1... In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ... In anatomy of the digestive system, the duodenum is a hollow jointed tube connecting the stomach to the jejunum. ... Cholecystokinin (CCK, previously pancreozymin) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. ... Gastric inhibitory peptide (GIP) is a gastrointestinal hormone secreted by the duodenum. ... Secretin is a hormone produced in the S cells of the duodenum in response to low duodenum pH and fatty acids in the duodenum to stimulate the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunners glands) when the pH drops below a set value. ... Motilin is a polypeptide hormone secreted by the small intestine that increases gastrointestinal motility and stimulates the production of pepsin. ... VIP is a peptide hormone containing 28 amino acid residues. ... Grays Fig. ... An editor has expressed a concern that the topic of this article may be unencyclopedic. ...


  Results from FactBites:
 
Growth hormone releasing hormone - Wikipedia, the free encyclopedia (246 words)
Growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GRF or GHRF), is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.
GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion.
GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH.
Growth Hormone (1222 words)
Growth hormone, also known as somatotropin, is a protein hormone of about 190 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary.
Growth hormone is also of considerable interest as a drug used in both humans and animals.
Growth hormone is often said to have anti-insulin activity, because it supresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver.
  More results at FactBites »

 
 

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