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Encyclopedia > Glyceryl trinitrate

Glyceryl trinitrate (GTN) is the pharmaceutical name for nitroglycerin. GTN is a vasodilator which is used in the treatment and prophylaxis of angina. Intravenous infusion can also be used to treat pulmonary edema. Pharmacology (in Greek: pharmacon is drug, and logos is science) is the study of how chemical substances interfere with living systems. ... Nitroglycerin, also known as nitroglycerine, trinitroglycerin, and glyceryl trinitrate, is a chemical compound, a heavy, colorless, poisonous, oily, explosive liquid obtained by nitrating glycerol. ... A vasodilator is a substance that causes blood vessels in the body to become wider by relaxing the smooth muscle in the vessel wall. ... For Prophylaxis, a particular school of thought in chess pioneered by Tigran Petrosian, please refer to the article on Petrosian. ... Angina pectoris (Latin for chest constriction) is the result of a lack of oxygen supply to the heart muscle, due to a reduced blood flow around the hearts blood vessels. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... Pulmonary Edema is swelling and/or fluid accumulation in the lungs. ...

The origins of the medical use (possibly apocryphal) stem from some workers at Alfred Nobel's nitroglycerin factory finding that their angina improved while they were inhaling airborne nitroglycerin. Medicine is a branch of health science concerned with restoring and maintaining health. ... Alfred Nobel Alfred Bernhard Nobel  listen (October 21, 1833, Stockholm, Sweden – December 10, 1896, San Remo, Italy). ...

Nitrates edit (http://en.wikipedia.org/w/index.php?title=Template:Antianginals_%28nitrates%29&action=edit)

{Glyceryl trinitrate} {Isosorbide dinitrate} {Isosorbide mononitrate} {Molsidomine} {Pentaerythritol tetranitrate} Nitrates are the salts of nitric acid. ... Isosorbide dinitrate is a nitrate used pharmacologically as a vasodilator, e. ... Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure. ... PETN (Pentaerythritol Tetranitrate, also known as Penthrite) is one of the strongest known high explosives, with a relative effectiveness factor (R.E. factor) of 1. ...

  Results from FactBites:
Data Sheet (1678 words)
Glyceryl trinitrate is a smooth muscle relaxant with vascular effects manifested predominantly by venous dilation with pooling.
The major beneficial effect of glyceryl trinitrate in angina pectoris is a reduction in myocardial oxygen consumption secondary to vascular dilation with resultant reduction in cardiac preload and afterload.
Continuous glyceryl trinitrate infusion at 3.1 to 4.0 mg/hr for 2-4 weeks in 36 patients resulted in an average methaemoglobin level of 0.2%, which was comparable to the level observed in patients receiving placebo.
  More results at FactBites »



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