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Encyclopedia > Gilead Sciences
Gilead Sciences
image:GileadSciencesLogo.gif
Type Public NASDAQ: GILD
Founded Foster City, California (1987)
Headquarters Foster City, California
Key people John Martin, President and Chief Executive Officer
Industry Healthcare, Biotechnology, Pharmaceutical company
Products Truvada, Viread, Emtriva, AmBisome, Hepsera, Tamiflu, Vistide
Revenue 2.028 billion USD (2005)
Operating income 1.111 billion USD (2005)
Net income 813.9 million USD (2005)
Employees 1900
Website www.gilead.com

Gilead Sciences NASDAQ: GILD is a biopharmaceutical company that discovers, develops and commercializes therapeutics to advance the care of patients suffering from life-threatening diseases, principally HIV, hepatitis B and influenza. The company has seven commercially available products and focuses its research and clinical programs on anti-infectives. Headquartered in Foster City, California, Gilead has operations in North America, Europe and Australia. As of Jan. 31, 2006, the company had 1,900 full-time employees.[1] Image File history File links GileadSciencesLogo. ... A public company is a company owned by the public rather than by relatively few individuals. ... NASDAQ in Times Square, New York City. ... Aerial view of Foster City Foster City is an affluent planned city located in San Mateo County, California. ... 1987 (MCMLXXXVII) was a common year starting on Thursday of the Gregorian calendar. ... Aerial view of Foster City Foster City is an affluent planned city located in San Mateo County, California. ... John Martin may refer to: John Martin (Bailiff of Guernsey), Bailiff of Guernsey (1499-1510) John Martin, (d. ... Health care or healthcare is one of the worlds largest and fastest growing professions. ... The structure of insulin Biotechnology is technology based on biology, especially when used in agriculture, food science, and medicine. ... A pharmaceutical company, or drug company, is a commercial business licensed to research, develop, market and/or distribute drugs, most commonly in the context of healthcare. ... Truvada is an antiretroviral drug used for the treatment of HIV. It consists of 300 milligrams of tenofovir and 200 milligrams of emtricitabine. ... Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Amphotericin B (Fungilin®, Fungizone®, Abelcet®, AmBisome®, Fungisome®, Amphocil®, Amphotec®) is a polyene antimycotic drug, used intravenously in systemic fungal infections. ... Adefovir dipivoxil, previously called bis-POM PMEA, is an orally-administered nucleotide analogue reverse transcriptase inhibitor (NtRTI), which works by blocking DNA polymerase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. ... Tamiflu manufactured by ROCHE active principle Oseltamivir Phosphate Drug Nomenclature Synonyms: GS-4104/002; Oseltamivir, fosfato de; Ro-64-0796/002 USAN: Oseltamivir Phosphate rINNM: Oseltamivir Phosphate erINNM: Fosfato de oseltamivir Chemical name: Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (1... Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Revenue is a U.S. business term for the amount of money that a company earns from its activities in a given period, mostly from sales of products and/or services to customers. ... The United States dollar is the official currency of the United States. ... Earnings before interest and taxes (EBIT), also known as operating income and operating profit, is a term used to describe a companys earnings. ... The United States dollar is the official currency of the United States. ... Net income is equal to the income that a firm has after subtracting costs and expenses from the total revenue. ... The United States dollar is the official currency of the United States. ... Employment is a contract between two parties, one being the employer and the other being the employee. ... A website (or Web site) is a collection of web pages, typically common to a particular domain name or subdomain on the World Wide Web on the Internet. ... NASDAQ in Times Square, New York City. ... Biopharmaceuticals are medical drugs (see pharmacology) produced by biotechnology. ... Medicine on the Web NLM (National Library of Medicine, contains resources for patients and healthcare professionals) Virtual Hospital (digital health sciences library by the University of Iowa) Online Medical Dictionary Collection of links to free medical resources Categories: Medicine | Health ... Human immunodeficiency virus or HIV is a retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. ... Hepatitis B is a disease of the liver caused by the Hepatitis B virus (HBV), a member of the Hepadnavirus family[1] and one of several unrelated viral species which cause viral hepatitis. ... Influenza, commonly known as the flu, is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses). ... Aerial view of Foster City Foster City is an affluent planned city located in San Mateo County, California. ...


The company's name and logo refer to the Balm of Gilead. Gilead (a place mentioned in the Bible) was famed for its small trees that produced a resin used in medicine. The leaf in the logo symbolizes healing, life and growth, while the shield represents safety, strength and honor. Together they signify Gilead's efforts to use the healing power of science to create medicines that treat life-threatening diseases. Balm of Gilead is a healing compound made from the resinous gum of a bush which grew plentifully in the area of Gilead. ... From the Scriptures, Gilead means hill of testimony or mound of witness, (Gen. ... Resin of a pine Insect trapped in resin. ...


Gilead is a member of the NASDAQ Biotechnology Index and the S&P 500. The NASDAQ Biotechnology Index includes securities of NASDAQ-listed companies classified according to the Industry Classification Benchmark as either Biotechnology or Pharmaceuticals which also meet other eligibility criteria. ... The S&P 500 is an index containing the stocks of 500 Large-Cap corporations, most of which are American. ...

Contents

History

Gilead Sciences was formed in June 1987 by Michael Riordan. Its development of small molecule antiviral therapeutics begins with the licensing in 1991 of nucleotide compounds discovered in two European academic labs.


In 1990, Gilead entered into a collaborative research agreement with Glaxo for the research and development of genetic code blockers, also known as antisense. This collaboration was terminated in 1998, and Gilead's antisense intellectual property portfolio was sold to Isis Pharmaceuticals. GlaxoSmithKline plc (LSE: GSK NYSE: GSK) is a British based pharmaceutical, biologicals, and healthcare company. ... Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. ... // Top 50 pharmaceutical companies The following is a list of the top 50 pharmaceutical and biotech companies ranked by healthcare revenue. ...


In June 1996, Gilead launched its first commercial product, Vistide (cidofovir injection) for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. The company cooperated with Pharmacia & Upjohn to market the product outside the U.S.A. Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Species see text Cytomegalovirus (CMV), is a genus of Herpes viruses; in humans the species is known as Human herpesvirus 5 (HHV-5). ... The retinitis is defined as the inflammation of the retina. ... This article is about the syndrome. ... Pharmacia was originally a government owned Swedish pharmaceutical company. ...


In 1999 Gilead acquired NeXstar Pharmaceuticals of Boulder, Colorado. In the same year, Roche announced first approval of Tamiflu (oseltamivir) for the treatment of influenza. Tamiflu was originally discovered by Gilead and licensed to Roche for late-phase development and marketing. The City of Boulder (, Mountain Time Zone) is a home rule municipality located in Boulder County, Colorado, United States. ... Hoffmann-La Roche, Ltd. ... Oseltamivir (INN) (IPA: ) is an antiviral drug used in the treatment and prophylaxis of both Influenzavirus A and Influenzavirus B. Like zanamivir, oseltamivir is a neuraminidase inhibitor. ... Influenza, commonly known as the flu, is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses). ...


Viread (tenofovir) achieved first approval in 2001 for the treatment of HIV. Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Human immunodeficiency virus or HIV is a retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. ...


In January 2003 Gilead completed its acquisition of Triangle Pharmaceuticals. The company also announced its first full year of profitability. Later that year Hepsera (adefovir) was approved for the treatment of chronic hepatitis B, and Emtriva (emtricitabine) for the treatment of HIV. Adefovir dipivoxil, previously called bis-POM PMEA, is an orally-administered nucleotide analogue reverse transcriptase inhibitor (NtRTI), which works by blocking DNA polymerase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. ... Hepatitis B is a disease of the liver caused by the Hepatitis B virus (HBV), a member of the Hepadnavirus family[1] and one of several unrelated viral species which cause viral hepatitis. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Human immunodeficiency virus or HIV is a retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. ...


In 2004 Gilead launched Truvada, a fixed-dose combination of tenofovir and emtricitabine. Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ...


In January 1997, Donald Rumsfeld, a Board member since 1988, was appointed Chairman of the company [2]. He stood down from the Board in January 2001 when appointed Secretary of Defense at the start of George W. Bush's first term as President. Federal disclosure forms indicate that Rumsfeld owns between USD$5 million and USD$25 million in Gilead stock (Schwartz 2005 [3]). The rise in Gilead's share prices from USD$35 to USD$57 per share will have added between USD$2.5 million to USD$15.5 million to Rumsfeld's net worth. Donald Henry Rumsfeld, (born July 9, 1932) is a U.S. politician and businessman, who was the 13th Secretary of Defense under President Gerald Ford from 1975–1977, and the 21st Secretary of Defense under President George W. Bush from 2001–2006. ... The United States Secretary of Defense is the head of the United States Department of Defense, concerned with the armed services and The Secretary is a member of the Presidents Cabinet. ... George Walker Bush (born July 6, 1946) is the 43rd and current President of the United States, inaugurated on January 20, 2001. ...


In November 2005, George W. Bush urged Congress to pass $7.1 billion in emergency funding to prepare for the possible bird flu pandemic, of which one billion is solely dedicated to the purchase, and distribution of Tamiflu. Avian influenza (also known as bird flu) is a type of influenza virulent in birds. ...


In July 2006, the FDA approved Atripla (TM), a once a day single tablet regimen for HIV, combining Sustiva (efavirenz), a Bristol-Myers Squibb product, and Truvada (emtricitabine and tenofovir disoproxil fumarate), a Gilead product. There are very few or no other articles that link to this one. ... This article needs to be cleaned up to conform to a higher standard of quality. ... Bristol-Myers Squibb (NYSE: BMY), colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company, founded in 1887 by William McLaren Bristol and John Ripley Myers in Clinton, NY (both were graduates of Hamilton College), and Squibb Corporation. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Viread Logo Tenofovir disoproxil fumarate Tenofovir disoproxil fumarate (TDF), marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ...


In November 2006, Gilead acquired Myogen, Inc. At the time, Myogen was in Phase III trials with ambrisentan, an orally available endothelin receptor antagonist, for the potential treatment of pulmonary arterial hypertension. Myogen was also conducting Phase III trials of darusentan, also an endothelin receptor antagonist, for the potential treatment of resistant hypertension. Additionally, under an agreement with GlaxoSmithKline, Myogen was marketing and distributing Flolan(R) (epoprstenol sodium) in the United States.


On December 18, 2006, Gilead submitted a New Drug Application to the U.S. FDA for marketing approval of 5 mg and 10 mg doses of ambrisentan--one of Myogen's drugs prior to its acquisition by Gilead--for the once-daily treatment of pulmonary arterial hypertension. On February 16, 2007, Gilead announced that the FDA had granted Priority Review for that NDA, meaning that it would review this application faster than normal.[4]. The FDA has set a target date of June 18, 2007 for completion of the review.


Financial highlights

Fiscal year 2005 (ended Dec. 31, 2005)[5][6]

 GAAP NON-GAAP Total Revenues $2.028 billion $2.028 billion Net Product Sales $1.809 billion $1.809 billion Total Expenses $917.3 million $917.3 million Net Income $813.9 million $788.8 million EPS $1.72 per diluted share $1.66 per diluted share Cash and Equivalents $707.0 million Stock Split (2-for-1) September 2004 (most recent) 

Senior Management

Gilead's Executive Committee is responsible for making the critical decisions that determine the company's future. Its members include:

  • John Martin, President and Chief Executive Officer
  • John Milligan, Executive Vice President and Chief Financial Officer
  • Norbert Bischofberger, Executive Vice President, Research and Development
  • Kevin Young, Executive Vice President, Commercial Operations
  • Gregg Alton, Vice President and General Counsel
  • Tony Caracciolo, Senior Vice President, Manufacturing
  • William Lee, Senior Vice President, Research
  • John Toole, Senior Vice President, Clinical Research
  • Taiyin Yang, Senior Vice President, Pharmaceutical Development and Manufacturing

Product portfolio

As of February 2007, Gilead had seven products on the market, all tackling potentially life-threatening infectious diseases.

There are very few or no other articles that link to this one. ... Truvada is an antiretroviral drug used for the treatment of HIV. It consists of 300 milligrams of tenofovir and 200 milligrams of emtricitabine. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. ... Amphotericin B (Fungilin®, Fungizone®, Abelcet®, AmBisome®, Fungisome®, Amphocil®, Amphotec®) is a polyene antimycotic drug, used intravenously in systemic fungal infections. ... Adefovir dipivoxil, previously called bis-POM PMEA, is an orally-administered nucleotide analogue reverse transcriptase inhibitor (NtRTI), which works by blocking DNA polymerase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. ... Adefovir dipivoxil, previously called bis-POM PMEA, is an orally-administered nucleotide analogue reverse transcriptase inhibitor (NtRTI), which works by blocking DNA polymerase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. ... Tamiflu manufactured by ROCHE active principle Oseltamivir Phosphate Drug Nomenclature Synonyms: GS-4104/002; Oseltamivir, fosfato de; Ro-64-0796/002 USAN: Oseltamivir Phosphate rINNM: Oseltamivir Phosphate erINNM: Fosfato de oseltamivir Chemical name: Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (1... Oseltamivir (INN) (IPA: ) is an antiviral drug used in the treatment and prophylaxis of both Influenzavirus A and Influenzavirus B. Like zanamivir, oseltamivir is a neuraminidase inhibitor. ... Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ...

External links

  • Gilead corporate web site
  • Gilead Sciences company profile from Yahoo!
  • Press Release on 2005 Financial Results
  • 10-K for Fiscal Year 2005
  • Gilead Sciences, Inc. (Oct. 2, 2006). Gilead Sciences to Acquire Myogen, Inc. for $2.5 Billion (Press Release).

  Results from FactBites:
 
Gilead -- Careers (171 words)
Gilead people are accomplished experts driven to make a difference in the lives of patients suffering from life-threatening diseases worldwide.
With approximately 1,800 employees around the globe, Gilead engages approximately 60 percent of its staff in research and development functions, 23 percent in sales and marketing and 17 percent in general and administrative positions.
Gilead Sciences is proud to be an equal opportunity employer and extends employment to men and women from culturally diverse backgrounds.
  More results at FactBites »

 
 

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