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Encyclopedia > Fusidic acid
Fusidic acid chemical structure
Fusidic acid
Systematic (IUPAC) name
2-(16-acetyloxy-3,11-dihydroxy-4,8,10,14- tetramethyl- 2,3,4, 5,6,7, 9,11,12, 13,15,16- dodecahydro- 1H-cyclopenta [a]phenanthren-17-ylidene) -6-methyl- hept-5-enoic acid
Identifiers
CAS number 6990-06-3
ATC code J01XC01
PubChem  ?
Chemical data
Formula C31H48O6
Mol. weight 516.709
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Fusidic_acid. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Fusidic acid is an antibacterial antibiotic used particularly for eye and skin infections. It works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome, although it works only on gram-positive bacteria such as Staphylococcus aureus, Streptococcus and Corynebacterium minutissimum. It was first isolated in 1962 from the fungus Fusidium coccineum, and later from Mucor ramannianus and Isaria kogana. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An antiseptic is a substance that kills or prevents the growth of bacteria on the external surfaces of the body. ... An antibiotic is a drug that kills or slows the growth of bacteria. ... gonfly]].]] In most vertebrates and some mollusks, the eye works by allowing light to enter it and project onto a light-sensitive panel of cells known as the retina at the rear of the eye, where the light is detected and converted into electrical signals, which are then transmitted to... For alternate meanings see skin (disambiguation). ... Phyla/Divisions Actinobacteria Aquificae Bacteroidetes/Chlorobi Chlamydiae/Verrucomicrobia Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Nitrospirae Omnibacteria Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Bacteria (singular, bacterium) are a major group of living organisms. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Figure 1: Ribosome structure indicating small subunit (A) and large subunit (B). ... Gram-positive bacteria are those that are stained dark blue or violet by gram staining, in contrast to gram-negative bacteria, which are not affected by the stain. ... Species S. aureus S. caprae S. epidermidis S. haemolyticus S. hominis S. lugdunensis S. saprophyticus S. warneri S. xylosus Staphylococcus (in Greek staphyle means bunch of grapes and coccos means granule) is a genus of gram-positive bacteria. ... Species S. agalactiae S. bovis S. mutans S. pneumoniae S. pyogenes S. salivarius S. sanguinis S. suis Streptococcus viridans group etc. ... Species See text. ... 1962 (MCMLXII) was a common year starting on Monday (the link is to a full 1962 calendar). ... Species See section. ...


It is delivered as an ointment, a cream, eye drops or in tablet form. An ointment is a viscous semisolid preparation used topically on a variety of body surfaces. ... A cream is a topical preparation usually for application to the skin. ... Eye drops are saline-containing drops used as a vector to administer medication in the eye. ... Common disk-shaped tablets A pharmacological tablet is a medicinal or other active substance mixed with binder powders and pressed into a tablet form. ...


Brand names

  • Fusidin (of Leo in Canada)
  • Fucidin (of Leo in UK)
  • Fucithalmic (of Leo in UK and Denmark)
  • Fucicort
  • Fucibet

References

  • RxMed Monograph
  • Synthesis of photoreactive fusidic acid analogues for binding studies with elongation factor G

  Results from FactBites:
 
News - Interaction of Fusidic Acid With Lipid Membranes: Implications to the Mechanism of Antibiotic Activity (8073 words)
Fusidic acid inhibits polypeptidc chain elongation by binding to the ribosomeelongation factor-G (EF-G)-GDP complex and thereby preventing the dissociation of EF-G from the ribosome (3).
Each individual fusidic acid molecule replacing one DPPC was set in a membrane such that its orientation was in line with the orientation of the removed DPPC molecule.
Characterization of DPPC/fusidic acid and DPPC/cholesterol bilayers by fluorescence spectroscopy
Fusidic acid - Wikipedia, the free encyclopedia (138 words)
Fusidic acid is an antibacterial antibiotic used particularly for eye and skin infections.
Fusidic acid is also used to cure knob rot
Synthesis of photoreactive fusidic acid analogues for binding studies with elongation factor G
  More results at FactBites »

 
 

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