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Encyclopedia > Foscarnet
Foscarnet
Systematic (IUPAC) name
phosphonomethanoic acid
Identifiers
CAS number 63585-09-1
ATC code J05AD01
PubChem 3415
DrugBank APRD00669
Chemical data
Formula CH3O5P 
Mol. mass 126.005 g/mol
300.1 g/mol (foscarnet trisodium hexahydrate)
Pharmacokinetic data
Bioavailability NA
Protein binding 14-17%
Metabolism  ?
Half life 3.3-6.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B3 (Au), C (U.S.) Image File history File links No higher resolution available. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... For other uses, see Carbon (disambiguation). ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, symbol, number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, period, block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... General Name, symbol, number phosphorus, P, 15 Chemical series nonmetals Group, period, block 15, 3, p Appearance waxy white/ red/ black/ colorless Standard atomic weight 30. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... BIC pen cap, about 1 gram. ... The mole (symbol: mol) is the SI base unit that measures an amount of substance. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... A drugs efficacy may be affected by the degree to which it binds to the proteins within blood plasma. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... The kidneys are important excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... For other uses, see Australia (disambiguation). ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

℞-only (U.S.), POM (UK) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained. ...

Routes Intravenous

Foscarnet is the conjugate base of the chemical compound with the formula HO2CPO3H2. This phosphonic acid derivative is (marketed by AstraZeneca as foscarnet sodium under the trade name Foscavir®) is an antiviral medication used to treat herpes viruses, including cytomegalovirus (CMV) and herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2). It is particularly used to treat CMV retinitis. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. ... Intravenous therapy or IV therapy is the giving of liquid substances directly into a vein. ... In the field of chemistry, in the Brønsted-Lowry (protonic) theory of acids and bases, a conjugate base is the basic member, X-, of a pair of compounds that differ only by the presence or absence of a proton at a certain position. ... A chemical compound is a chemical substance of two or more different chemically bonded chemical elements, with a fixed ratio determining the composition. ... A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... Tautomers of H3PO3: phosphonic acid (left) phosphorous acid (right) The general structure of an organic phosphonic acid In inorganic chemistry, phosphonic acid is a phosphorus oxoacid with a formula of H3PO3, more commonly known as phosphorous acid. ... AstraZeneca PLC (LSE: AZN, NYSE: AZN), is a large Anglo-Swedish pharmaceutical company formed on 6 April 1999 by the merger of Swedish Astra AB and British Zeneca Group. ... For sodium in the diet, see Edible salt. ... Antiviral drugs are a class of medication used specifically for treating viral infections. ... This article does not cite any references or sources. ... In colloquial use, herpes virus refers to the herpes simplex virus, particularly when transmitted sexually. ... Species see text Cytomegalovirus (CMV) (from the Greek cyto-, cell, and -mega-, large) is a viral genus of the Herpesviruses group: in humans it is commonly known as human herpesvirus 5 (HHV-5). ... This article is about the disease. ... Cytomegalovirus Retinitis CMV (Cytomegalovirus) is a DNA virus in the family Herpesviridae. ...


Mechanism of action

Foscarnet is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases. Because foscarnet is not activated by thymidine kinase, it maintains activity in some viruses which have lost thymidine kinase activity to gain resistance to aciclovir or ganciclovir. Therefore, foscarnet is often used in aciclovir- or ganciclovir-resistant disease. However, acyclovir or ganciclovir resistant mutants with alterations in viral DNA polymerase may be resistant to foscarnet. In chemistry, the anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. ... 3D structure of the DNA-binding helix-hairpin-helix motifs in human DNA polymerase beta A DNA polymerase is an enzyme that assists in DNA replication. ... For other uses, see Concentration (disambiguation). ... Thymidine kinase TK, is an enzyme, a phosphotransferase (a kinase): 2-deoxythymidine kinase, ATP-thymidine 5-phosphotransferase, {{{EC 2. ... Aciclovir (INN) (IPA: ) or acyclovir (USAN, former BAN) is a guanine analogue antiviral drug primarily used for the treatment of herpes simplex virus infection. ... Ganciclovir (INN) (IPA: ) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections, and there are many errors and omissions in this article. ...


Administration

Intravenous only An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ...


Side effects

1. Nephrotoxicity - Increase in serum creatinine levels occurs on average in 45% of patients receiving foscarnet. Other nephrotoxic drugs should be avoided. Nephrotoxicity is usually reversible and can be reduced by dosage adjustment and adequate hydration.


2. Electrolyte distrubances - Changes in calcium, magnesium, potassium and phosphate levels occurs commonly and regular monitoring of electrolytes is necessary to avoid clinical toxicity.


3. Genital ulceration - Occurs more commonly in men and usually occurs during induction use of foscarnet. It is most likely a contact dermatitis due to high concentrations of foscarnet in urine. It usually resolves rapidly following discontinuation of the drug.


  Results from FactBites:
 
FOSCARNET Faq (734 words)
Foscarnet is an antiviral medication used to treat infection with cytomegalovirus (CMV).
Occassionally foscarnet also has been used to a limited extent to treat severe herpes simplex viral infections in patients who have not responded to, or who have developed severe side effects to the antiviral agent acyclovir.
Foscarnet is supplied in either glass bottles or I.V. bags in a concentration of either 24 mg/ml (usually) or 12 mg/ml.
  More results at FactBites »

 
 

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