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Encyclopedia > Fomivirsen
Image:Fomivirsen.png
Fomivirsen
Systematic (IUPAC) name
 ?
Identifiers
CAS number 160369-77-7
ATC code S01AD08
PubChem  ?
Chemical data
Formula  ?
Mol. weight  ?
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B2 IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... It has been suggested that this article or section be merged with cell metabolism and carbohydrates. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Fomivirsen (brand name "Vitravene") is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Antiviral drugs are a class of medication used specifically for treating viral infections. ... CMV (Cytomegalovirus) is a DNA virus in the family Herpesviridae. ... Immunosuppression is the medical suppression of the immune system. ... This article is about the acquired immune deficiency syndrome. ...


It is an oligonucleotide that blocks transcription of viral mRNA by bindng to a coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA. Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer base pairs. ... Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. ...


See also

The retinitis is defined as the inflammation of the retina. ...

External links

  • Diagram
  • MedlinePlus DrugInfo uspdi-203675
  • DDB 31313
  • (2001) "Fomivirsen.". Drugs Today (Barc) 37 (4): 245-255. PMID 12768225.
  • Geary R, Henry S, Grillone L (2002). "Fomivirsen: clinical pharmacology and potential drug interactions.". Clin Pharmacokinet 41 (4): 255-60. PMID 11978144.
  • (2002) "Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS.". Am J Ophthalmol 133 (4): 475-83. PMID 11931781.
  • Roehr B (1998). "Fomivirsen approved for CMV retinitis.". J Int Assoc Physicians AIDS Care 4 (10): 14-6. PMID 11365956.


MedlinePlus (medlineplus. ... The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ...

Antivirals (primarily J05A, also S01AD and D06BB) edit
Anti-herpesvirus agents   Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir
 
Antiretroviral drugs   NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
NtRTIs   Tenofovir
NNRTIs   Efavirenz, Delavirdine, Nevirapine
PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
Fusion inhibitors Enfuvirtide
 
Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine

  Results from FactBites:
 
AEGiS-PRn: Isis and CIBA Vision Present Statistically Significant Phase III Efficacy Results for Antisense CMV ... (1877 words)
Fomivirsen was the first antisense drug to demonstrate therapeutic activity in humans, and is the first antisense drug to complete Phase III clinical trials leading to a regulatory submission.
Fomivirsen appears to be a potent inhibitor of CMV, the virus that causes CMV retinitis in AIDS patients.
Fomivirsen is a local treatment, directly administered into the eye and is designed to work through an antisense mechanism of action to inhibit the production of viral proteins critical to the virus lifecycle and delay disease progression.
  More results at FactBites »

 
 

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