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Encyclopedia > Fibrous dysplasia

Fibrous Dysplasia is a disease that causes growths or lesions in one or more bones of the human body. These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone(s) can be involved. Many patients have lesions localized in only one bone (70-80%), but others have them in many bones. In many cases, people suffering from Fibrous Dysplasia also have endocrine diseases and skin pigmentation; the three together constitute McCune-Albright Syndrome. Fibrous Dysplasia is very rare, not much is known about it, and there is no known cure. However, it is known that it is caused by a genetic mutation that occurs sometime during fetal development, and is not hereditary. See the article about cancer for the main article about malignant tumors. ... The endocrine system is a control system of ductless endocrine glands that secrete chemical messengers called hormones that circulate within the body via the bloodstream to affect distant organs. ... For the scientific journal Heredity see Heredity (journal) Heredity (the adjective is hereditary) is the transfer of characters from parent to offspring, either through their genes or through the social institution called inheritance (for example, a title of nobility is passed from individual to individual according to relevant customs and...


External links

  • Fibrous Dysplasia Support Online FAQ
  • eMedicine Fibrous Dysplasia Page
  • The Paget Foundation

  Results from FactBites:
 
Skull Base Institute - Papers - Fibrous Dysplasia (653 words)
Fibrous dysplasia is a congenital, non-hereditary, progressive, skeletal disorder by which normal bone is replaced by a variable amount of structurally weak fibrous and osseous tissue.
Fibrous dysplasia is a progressive disease, which typically occurs early in childhood and continues until skeletal growth ceases.
Fibrous Dysplasia of the frontal and sphenoid bones eventually leads to distortion of facial features and skull shape as a result of the proliferation of thick dense bone.
Paget Foundation_Q&A (1859 words)
A.        Fibrous dysplasia is a chronic disorder of the skeleton characterized by one or more expansile areas in which normal bone is replaced by abnormal bone and fibrous tissue.
Fibrous dysplasia is caused by an abnormal chemical “switch” (called the Gs-alpha protein) in the affected cells, which results in their constant over-stimulation.
Thus, fibrous dysplasia is a congenital disorder, meaning that it is present from birth, although it may not be apparent until much later.
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