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Encyclopedia > Fibrosarcoma
Classification & external resources
ICD-O: 8810/3

Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. ... In medicine, malignant is a clinical term that is used to describe a clinical course that progresses rapidly to death. ... Tumor or tumour literally means swelling, and is sometimes still used with that meaning. ... The word proliferation can refer to: Nuclear proliferation Chemical weapon proliferation the spread in use of other weapons systems Cell proliferation According to Gloria Anzaldúa (1990), the difference between appropriation and proliferation is that the first steals and harms; the second helps heal breaches of knowledge. ... A fibroblast is a cell that makes the structural fibers and ground substance of connective tissue. ... Categories: Move to Wiktionary | Stub ...



The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing. It is deadly. Differentiation can mean the following: In biology: cellular differentiation; evolutionary differentiation; In mathematics: see: derivative In cosmogony: planetary differentiation Differentiation (geology); Differentiation (logic); Differentiation (marketing). ... Tropocollagen triple helix. ...

Fibrosarcoma in dogs and cats

Fibrosarcoma occurs most frequently in the mouth in dogs. The tumor is locally invasive, and recurs often following surgery. Radiation therapy and chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs.[1] Clinac 2100 C100 accelerator Radiation therapy (or Radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ... Chemotherapy is the use of chemical substances to treat disease. ...

In cats, fibrosarcoma occurs on the skin. It also the most common vaccine-associated sarcoma.[1] A vaccine-associated sarcoma (VAS) is a type of malignant tumor found in cats that has been linked to certain vaccines. ...


  1. ^ a b Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine, 4th ed., W.B. Saunders Company. ISBN 0-7216-6795-3. 

See also

... Soft Fibroma (fibroma molle). ...

External links

  • Atlas of Pathology

  Results from FactBites:
Fibrosarcoma in cats (3782 words)
Fibrosarcomas are an extremely aggressive tumor and this would be the most common scenario.
Fibrosarcomas are very aggressive tumors and a wide surgical margin -- at least an inch in EVERY direction is necessary when removing these to try to prevent spread of the tumor.
Fibrosarcomas on any part of the body in which they can be surgically removed and then treated with radiation therapy and chemotherapy have about a 30% survival rate after 18 months or so, as reported by oncologists on the Veterinary Information Network.
  More results at FactBites »



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