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Encyclopedia > Fibronectin
Fibronectin 1
Identifiers
Symbol(s) FN1
Entrez 2335
OMIM 135600
RefSeq NM_002026
UniProt P02751
Other data
Locus Chr. 2 q34-q36

Fibronectin is a high-molecular-weight glycoprotein containing about 5% carbohydrate that binds to receptor proteins that span the cell's membrane, called integrins. In addition to integrins, they also bind extracellular matrix components such as collagen, fibrin and heparin. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... A glycoprotein is a macromolecule composed of a protein and a carbohydrate (an oligosaccharide). ... Lactose is a disaccharide found in milk. ... Transmembrane receptors are integral membrane proteins, which reside and operate typically within a cells plasma membrane, but also in the membranes of some subcellular compartments and organelles. ... An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. ... An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. ... In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell. ... Tropocollagen triple helix. ... Fibrin is a protein involved in the clotting of blood. ... Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. ...


Fibronectin can be found in the blood plasma in its soluble form which is composed of two 250 kDa subunits joined together by disulfide bonds. Plasma fibronectin is made in the liver by hepatocytes. The insoluble form that was formerly called cold-insoluble globulin is a large complex of cross-linked subunits. Blood plasma is the liquid component of blood, in which the blood cells are suspended. ... Possible meanings: Kachin Defense Army Kentucky Distillers Association Kongsberg Defence & Aerospace This page expands a three-character combination which might be any or all of: an abbreviation, an acronym, an initialism, a word in English, or a word in another language. ... In chemistry, a disulfide bond is a single covalent bond derived from the coupling of thiol groups. ... Hepatocytes make up 60-80% of the cytoplasmic mass of the liver. ...


There are several isoforms of fibronectin all of which are the product of a single gene. The structure of these isoforms are made of three types of repeated internal regions called I, II and III which exhibit different lengths and presence or absence of disulfide bonds. Alternative splicing of the Pre-mRNA leads to the combination of these three types of regions but also to a variable region. Pre-mRNA (preliminary mRNA) is a single strand of ribonucleic acid (RNA), synthesized from the DNA in the nucleus of a cell by the process transcription. ...


Fibronectin is involved in the wound healing process and so can be used as a therapeutic agent. It is also one of the few proteins for which production increases with age without any associated pathology. Fibronectin is also found in normal human saliva, which helps prevent colonization of the oral cavity and pharynx by potentially pathogenic bacteria. Wound healing is usually divided into three distinct phases: the inflammatory phase, the proliferative phase, and the remodeling phase. ...


Fibronectin and Cancer


Fibronectin has been implicated in carcinoma development. In lung carcinoma, fibronectin expression is increased, especially in non–small cell lung carcinoma The adhesion of lung carcinoma cells to fibronectin enhances tumorigenicity and confers resistance to apoptosis induced by standard chemotherapeutic agents. Fibronectin has been shown to stimulate the phosphatidylinositol 3-kinase (PI3K), which is capable of controlling the expression of cyclin D and related genes involved in cell cycle control. This suggests that fibronectin promotes lung tumor growth/survival and resistance to therapy and could represent a novel target for the development of new anticancer drugs.


Structure of Fibronectin


Fibronectin is composed of two similar polypeptide chains of approximately 30 modules. These polypeptide chains are attached by disulfide bridges, and are folded into a linear series of 5 or 6 functional units. These functional units contain interaction sites for other Extracellular components or cell surface molecules. Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ...


Functions of Fibronectin


Other than the ones states previously, Fibronectin has numberous functions that ensure the normal funtioning of life. One of its more notable functions is its role as a 'guide' in cellular migration pathways in mammalian development, particularily the Neural Crest (ectoderm cells that will develop into skin pigment cells as well as some bones of the skull). Fibronectin helps maintain the shape of cells by lining up and organizing intracellular cytoskeleton by means of receptors. It helps stabilize the attachment of ECM (Extracellular matrix) to cells by acting as binding sites for cell surface receptors. More generally though, Fibronectin helps create a cross-linked network within the Extracellular Matrix by having binding sites for other ECM components. The neural crest, a component of the ectoderm, is one of several ridgelike clusters of cells found on either side of the neural tube in vertebrate embryos. ... The ectoderm is outermost of the three germ layers of the developing embryo, the other two being the mesoderm and the endoderm. ... The eukaryotic cytoskeleton. ... In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell. ...


External links

  • Fibronectin in NCBI
  • Fibronectin antibody and other reagents

Han, Fibronectin Stimulates Non–Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways Cancer Research 66, 315-323, January 1, 2006


  Results from FactBites:
 
Innovative Research, Inc - "The researcher's source for biomedical products". (199 words)
Human fibronectin is an adhesive glycoprotein found in the extracellular matrix and in plasma (1).
Fibronectin is composed of two nearly identical polypeptide chains linked by a pair of disulfide bonds.
The human fibronectin provided is suitable to promote the adhesion and propagation of cells in vitro when used to coat cell culture surfaces, including plasticware, glassware and microcarrier beads.
Haematologic Technologies - Human Fibronectin (454 words)
Fibronectin (cold-insoluble globulin) is a high molecular weight, adhesive, glycoprotein found in both plasma (1) and the extracellular matrix (2).
Fibrin-fibronectin complexes are stabilized by the factor XIIIa-catalyzed covalent cross-linking of fibronectin to the a chain of fibrin (18).
Fibronectin is isolated from human plasma by thermal precipitation, ion exchange, and gelatin-agarose affinity chromatography.
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