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Encyclopedia > Etodolac
Systematic (IUPAC) name
1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid
CAS number 41340-25-4
ATC code M01AB08
PubChem 3308
DrugBank APRD00067
Chemical data
Formula C17H21NO3
Mol. weight 287.354 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 100%
Metabolism  ?
Half life 7.3 ± 4.0 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Etodolac is the International Nonproprietary Name (INN) of 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid (empirical formula C17H21NO3), also sold under the trade name Lodine. It is a non-steroidal anti-inflammatory drug (NSAID). It is used to treat pain associated with arthritis and other conditions. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... In chemistry, the empirical formula of a chemical is a simple expression of the relative number of each type of atom (called a chemical element) in it. ... A trade name, also known as a trading name or a business name, is the legal name of a business, or the name which a business trades under for commercial purposes. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a group of conditions where there is damage caused to the joints of the body. ...

External links

  • Information on Etodolac from rxlist.com


  Results from FactBites:
Etodolac - RxList Generic Information (5071 words)
Etodolac is well absorbed and had a relative bioavailability of 100% when 200 mg capsules were compared with a solution of etodolac.
Free etodolac clearance was not altered, indicating the importance of protein binding in etodolac's disposition.
The recommended dose of Etodolac for the management of the signs and symptoms of osteoarthritis is initially 800 to 1200 mg/day in divided doses, followed by dosage adjustment within the range of 600 to 1200 mg/day given in divided doses: 400 mg t.i.d.
Veterinary Products... etodolac (3059 words)
Results: 10 mg/kg: Toxicity of etodolac was minimal with adverse reactions being absent or generally mild and transitory and included mild weight loss and fecal alterations (loose or mucoid feces, diarrhea or presence of blood).
The extent of etodolac absorption (AUC) is not affected by the prandial status of the animal.
Conclusions: The extent of etodolac absorption (AUC) is not affected by the prandial status of the animal.
  More results at FactBites »



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