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Encyclopedia > Epoxide hydrolase

In general, the epoxide hydrolase system functions in detoxication during drug metabolism. It converts epoxides trans-dihydrodiols. Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds.


  Results from FactBites:
 
Epoxide Hydrolase Bibliography (4589 words)
0 epoxide by a cytosolic epoxide hydrolase from mouse liver.
  Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase.
  Inhibition of microsomal epoxide hydrolases by ureas, amides and amines.
Epoxide hydrolase - Wikipedia, the free encyclopedia (91 words)
It converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body.
Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic.
Epoxide hydrolase is present in large quantity on endoplasmic recticulum.
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