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Encyclopedia > Entrez
The Entrez logo
The Entrez logo

The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. NCBI is part of the National Library of Medicine (NLM), itself a department of the National Institutes of Health (NIH) of the United States government. Image File history File links Entrez. ... Image File history File links Entrez. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... The United States National Library of Medicine (NLM), operated by the United States federal government, is the worlds largest medical library. ... The National Institutes of Health (NIH) is the primary agency of the United States government responsible for medical research. ... ...




Entrez is a powerful federated search engine, or web portal that allows users to search a multiple of discrete health sciences databases, maintained by the National Center for Biotechnology Information with a single query string and user interface. NCBI includes the following databases: Federated searching consists of transforming a query and broadcasting it to a group of disparate databases with the appropriate syntax, merging the results collected from the databases, presenting them in a succinct and unified format with minimal duplication, and allowing the library patron to sort the merged result set by... Web portals are sites on the World Wide Web that typically provide personalized capabilities to their visitors. ... Health science is the discipline of applied science which deals with human and animal health. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ...

  • PubMed: biomedical literature citations and abstracts, including Medline - articles from (mainly medical) journals, often including abstracts. Links to PubMed Central and other full-text resources are provided to articles from the 1990s.
  • PubMed Central: free, full text journal articles
  • Site Search: NCBI web and FTP web sites
  • Books: online books
  • OMIM: online Mendelian Inheritance in Man
  • OMIA: online Mendelian Inheritance in Animals
  • Nucleotide: sequence database (GenBank)
  • Protein: sequence database
  • Genome: whole genome sequences and Mapping
  • Structure: three-dimensional macromolecular structures
  • Taxonomy: organisms in GenBank Taxonomy
  • SNP: single nucleotide polymorphism
  • Gene: gene-centered information
  • HomoloGene: eukaryotic homology groups
  • PubChem Compound: unique small molecule chemical structures
  • PubChem Substance: deposited chemical substance records
  • Genome Project: genome project information
  • UniGene: gene-oriented clusters of transcript sequences
  • CDD: conserved protein domain database
  • 3D Domains: domains from Entrez Structure
  • UniSTS: markers and mapping data
  • PopSet: population study data sets (epidemiology)
  • GEO Profiles: expression and molecular abundance profiles
  • GEO DataSets: experimental sets of GEO data
  • Cancer Chromosomes: cytogenetic databases
  • PubChem BioAssay: bioactivity screens of chemical substances
  • GENSAT: gene expression atlas of mouse central nervous system
  • Probe: sequence-specific reagents

The Entrez system can provide views of gene and protein sequences and chromosome maps. Entrez can efficiently retrieve related sequences, structures, and references. Some textbooks are also available online through the Entrez system. Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously. Medline is a comprehensive literature database of life sciences and biomedical information. ... MEDLINE (MEDLINE, Medical Literature Analysis and Retrieval System Online) is the premier international literature database of life sciences and biomedical information. ... A medical journal is a scientific journal devoted to the field of medicine. ... Proceedings of the National Academy of Sciences. ... PubMed Central grew from the online Entrez PubMed biomedical literature search system. ... See also 1990s, the band The 1990s decade refers to the years from 1990 to 1999, inclusive, sometimes informally including popular culture from the very late 1980s and from 2000 and beyond. ... Mendelian inheritance (or Mendelian genetics or Mendelism) is a set of primary tenets that underlie much of genetics developed by Gregor Mendel in the latter part of the 19th century. ... The examples and perspective in this article or section may not represent a worldwide view. ... Linnaean taxonomy classifies living things into a hierarchy, originally starting with kingdoms. ... PubChem is a database of chemical molecules . ... PubChem is a database of chemical molecules . ... Genome projects are scientific endeavours that aim to map the genome of a living being or of a species (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus), that is, the complete set of genes caried by this living being or virus. ... Epidemiology is the scientific study of factors affecting the health and illness of individuals and populations, and serves as the foundation and logic of interventions made in the interest of public health and preventive medicine. ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Figure 1: Chromosome. ...



Main article: GenBank

The NCBI has had responsibility for making available the GenBank DNA sequence database since 1992. GenBank coordinates with individual laboratories and other sequence databases such as those of the European Molecular Biology Laboratory and the DNA Database of Japan. The GenBank sequence database is an annotated collection of all publicly available nucleotide sequences and their protein translations. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions for the biological development of a cellular form of life or a virus. ... As of 2004, there are around 500 public and commercial biological databases. ...

Since 1992, NCBI has grown to provide other databases in addition to GenBank. NCBI provides Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), the Unique Human Gene Sequence Collection, a Gene Map of the Human genome, a Taxonomy Browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project. 1992 (MCMXCII) was a leap year starting on Wednesday. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The human genome is the genome of Homo sapiens. ...

The NCBI has software tools that are available by WWW browsing or by FTP. For example, BLAST is a sequence similarity searching program. BLAST can do sequence comparisons against the GenBank DNA database in less than 15 seconds. WWWs historical logo designed by Robert Cailliau The World Wide Web (WWW or simply the Web) is a global, read-write information space. ... In bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing biological sequences, such as the amino-acid sequences of different proteins or the DNA sequences. ...


NLM Catalog

The NLM Catalog provides access to NLM bibliographic data for over 1.2 million journals, books, audiovisuals, computer software, electronic resources, and other materials via the NCBI Entrez retrieval system. Updated every weekday, the NLM Catalog is an alternative search interface to the bibliographic records resident in LocatorPlus.


See also

  • Chemistry resources

External link

  • Entrez search engine form
Databases supported by Bioinformatic Harvester
UniProt | SOURCE | SMART | SOSUI | PSORT | HomoloGene | GFP-cDNA | IPI | OMIM
NCBI-BLAST | Genome-Browser | Ensembl | RZPD | STRING | iHOP | Entrez

  Results from FactBites:
Entrez (350 words)
Entrez is a powerful search engine that can be applied to any of the large databases maintained by the NCBI.
The Entrez system can provide views of gene and protein sequences and chromosome maps.
Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously.
  More results at FactBites »



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