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Encyclopedia > Enoximone
Enoximone chemical structure
Enoximone
Systematic (IUPAC) name
4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-
dihydroimidazol-2-one
Identifiers
CAS number 77671-31-9
ATC code C01CE03
PubChem 53708
Chemical data
Formula C12H12N2O2S 
Mol. weight 248.302 g/mol
Pharmacokinetic data
Bioavailability 50% (oral)
Protein binding 85%
Metabolism Hepatic oxidation
Half life 4 to 10 hours
Excretion Renal (60 to 70%)
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ... General Name, Symbol, Number sulfur, S, 16 Chemical series nonmetals Group, Period, Block 16, 3, p Appearance lemon yellow Atomic mass 32. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The liver is the largest internal organ of the human body. ... The most fundamental reactions in chemistry are the redox processes. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status

POM(UK) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Routes Intravenous

Enoximone (INN, trade name PerfanĀ®) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.
In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... Imidazole is a heterocyclic aromatic organic compound. ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). ... Congestive heart failure (CHF), also called congestive cardiac failure (CCF) or just heart failure, is a condition that can result from any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. ...

Selective Phosphodiesterase inhibitors (C01CE, G04BE)edit
PDE1:

Vinpocetine A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a semisynthetic derivative of vincamine, which is extracted from the periwinkle plant. ...

PDE2:

EHNA EHNA (erythro-9-(2-hydroxy-3-nonyl)adenine) is a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type-2 (PDE2). ...

PDE3:

Amrinone, Bucladesine, Enoximone, Milrinone Amrinone (INN) or inamrinone, trade name Inocor®, is a pyridine phosphodiesterase inhibitor. ... Bucladesine is a phosphodiesterase inhibitor. ...

PDE4:

Rolipram

PDE5:

Sildenafil, Tadalafil, Vardenafil Sildenafil citrate, sold under the names Viagra, Revatio and generically under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. ... Tadalafil is a drug used to treat male erectile dysfunction (impotence). ... Vardenafil (INN) is a PDE5 inhibitor used in the treatment of erectile dysfunction. ...


  Results from FactBites:
 
Society of Cardiovascular Anesthesiologists (594 words)
Both dobutamine and enoximone increased heart rate (16% vs. 10%) and systolic blood pressure increased by 14% with dobutamine yet was unchanged with enoximone.
Enoximone, a nonglycoside, noncatechol, positive inotropic agent that inhibits cyclic adenosine monophosphate-specific phosphodiesterase, may represent a valid alternative to dobutamine for detection of viable myocardium.
Also, enoximone was not influenced by alpha- or beta-adrenoceptor blockers or by catecholamine depletion that may occur in heart failure and can attenuate response to dobutamine.
  More results at FactBites »

 
 

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