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Encyclopedia > Enflurane
Structural formula of enflurane
Structural formula of enflurane

Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluomethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966. Image File history File links Download high resolution version (1503x994, 17 KB) Summary Chemical structure of the anaesthetic enflurane, self made in ChemDraw and Photoshop by Ben. ... Image File history File links Download high resolution version (1503x994, 17 KB) Summary Chemical structure of the anaesthetic enflurane, self made in ChemDraw and Photoshop by Ben. ... A Halogenated Ether is a subcategory of a larger group of chemicals known as ethers. ... Cetacaine, a typical topical anesthetic Anesthesia (American English), also anaesthesia (British English), is the process of blocking the perception of pain and other sensations. ...


Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature. In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ... Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) is a halogenated ether used for inhalation anesthesia. ...


Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane. Myocardium is the muscular tissue of the heart. ... Contractility is one of the factors which affect myocardial performance. ... A fluoride ion is the ionic form of fluorine. ... Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) is a halogenated ether used for inhalation anesthesia. ...


Physical properties

Molecular weight 184.5 g/mol
Boiling point (at 1 atm): 56.5 °C
MAC : 1.68
Vapor pressure: 172 mmHg (at 20°C)
Blood:Gas Partition Coefficient: 1.9
Oil:Gas Partition Coefficient: 98

  Results from FactBites:
 
Biological monitoring of occupational exposure to enflurane (ethrane) in operating room personnel. - HighBeam ... (2780 words)
Enflurane in the ambient atmosphere was determined in 18 operating theaters of eight hospitals in Italy.
Enflurane was detected in urine of 159 exposed subjects (anesthetists, surgeons, and nurses).
Enflurane disappears rapidly from body tissues and disappears completely from blood during the period after the workshift,[31] thus precluding the use of blood fluorides 16 h after exposure as an indicator of the mean level of exposure during previous days.
Enflurane (531 words)
Enflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
Induction of and recovery from anesthesia with enflurane are rapid.
3 Desflurane, enflurane, halothane, isoflurane, and sevoflurane induce anesthetic preconditioning.
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