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Encyclopedia > Edwin G. Krebs

Dr Edwin Gerhard Krebs (born June 6, 1918) is an American biochemist. He received the Albert Lasker Award for Basic Medical Research in 1989 and, together with his collaborator Edmond H. Fischer, was awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. June 6 is the 157th day of the year in the Gregorian calendar (158th in leap years), with 208 days remaining // 1508 - Maximilian I, Holy Roman Emperor, is defeated in Friulia by Venetian forces; he is forced to sign a three-year truce and cede several territories to Venice 1513... 1918 (MCMXVIII) was a common year starting on Tuesday of the Gregorian calendar (see link for calendar) or a common year starting on Wednesday of the Julian calendar. ... The Albert Lasker Award for Basic Medical Research is awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease. ... 1989 (MCMLXXXIX) was a common year starting on Sunday of the Gregorian calendar. ... Dr Edmond H. Fischer (born April 6, 1920) is a Swiss-American biochemist. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... 1992 (MCMXCII) was a leap year starting on Wednesday. ... Phosphorylation is the addition of a phosphate (PO4) group to a protein or a small molecule. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...


Krebs was born in Lansing, Iowa, the third child of William Carl Krebs, a Presbyterian minister and Louise Helen (Stegeman) Krebs. The family moved frequently due to the nature of his father's work, though they settled in Greenville, Illinois when Krebs was six and remained there until his fathers unexpected death in 1933. Louise Krebs decided to move her family to Urbana, Illinois, where Krebs elder brothers were attending the University of Illionis. Krebs attended Urbana High School, and enrolled at the University of Illinois in 1936. In his fourth year of study Krebs had decided to either pursue a higher degree in organic chemistry or study medicine, receiving a scholarship to attend Washington University School of Medicine in St. Louis, he chose the latter. Lansing is a city located in Allamakee County, Iowa. ... Presbyterianism is part of the Reformed churches family of denominations of Christian Protestantism based on the teachings of John Calvin which traces its institutional roots to the Scottish Reformation, especially as led by John Knox. ... Greenville is a city located in Bond County, Illinois. ... 1933 (MCMXXXIII) was a common year starting on Sunday (link will take you to calendar). ... To meet Wikipedias quality standards, this article or section may require cleanup. ... The University of Illinois at Urbana-Champaign, also known as UIUC and the U of I (the officially preferred abbreviation), is the flagship campus in the University of Illinois system. ... 1936 (MCMXXXVI) was a leap year starting on Wednesday (link will take you to calendar). ... Organic chemistry is a specific discipline within the subject of chemistry. ... “Washington University” redirects here. ... Nickname: Gateway City, Gateway to the West, or Mound City Location in the state of Missouri Coordinates: Country United States State Missouri County Independent City Mayor Francis G. Slay (D) Area    - City 66. ...


The School of Medicine afforded Krebs the opportunity to train as a physician as well as experience in medical research. Following graduation in 1943 he undertook an 18 month residency at the Barnes Hospital in St. Louis, and then went on active duty as a medical officer in the Navy. Krebs was discharged from the Navy in 1946 and unable to immediately return to hospital work he was advised to study basic science. He chose to study biochemistry and was postdoctoral fellow to Carl and Gerty Cori, working on the interaction of protamine with rabbit muscle phosphorylase. At the completion of his two years study Krebs decided to continue his career as a biochemist. 1943 (MCMXLIII) was a common year starting on Friday (the link is to a full 1943 calendar). ... USN redirects here. ... 1946 (MCMXLVI) was a common year starting on Tuesday. ... Biochemistry is the study of the chemical processes and transformations in living organisms. ... Carl Ferdinand Cori (December 5, 1896 _ October 20, 1984) was an American biochemist born in Prague (then in Austria-Hungary) who, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in 1947 for their discovery of how glycogen (animal starch) - a derivative of... Gerty Theresa Cori, née Radnitz, (August 15, 1896 – October 26, 1957) was an American biochemist born in Prague (then Austria-Hungary) who, together with her husband Carl Ferdinand Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in Physiology or Medicine in 1947 for their discovery of... Protamine is a drug that reverses the anticoagulant effects of heparin by binding to it. ... Phosphorylase is an enzyme that catalyzes the production of glucose phosphate from glycogen and inorganic phosphate. ...


In 1948 Krebs accepted a position as assistant professor of biochemistry at the University of Washington, Seattle. When Edmond H. Fischer arrived at the Department in 1953, the pair decided to work on the enzymology of phosphorylase. During the course of their study they were able to observe mechanism by which interconversion of the two forms of phosphorylase takes place; reversible protein phosphorylation. To meet Wikipedias quality standards, this article or section may require cleanup. ... The University of Washington, founded in 1861, is a public research university in Seattle, Washington. ... City nickname Emerald City City bird Great Blue Heron City flower Dahlia City mottos The City of Flowers The City of Goodwill City song Seattle, the Peerless City Mayor Greg Nickels County King County Area   - Total   - Land   - Water   - % water 369. ... Dr Edmond H. Fischer (born April 6, 1920) is a Swiss-American biochemist. ... 1953 (MCMLIII) was a common year starting on Thursday. ... Phosphorylase is an enzyme that catalyzes the production of glucose phosphate from glycogen and inorganic phosphate. ...


Explained simply reverse protein phosphorylation works like this : a protein kinase moves a phosphate group from adenosine triphosphate (ATP) to a protein. The shape and the function of the protein is altered enabling it to take part in some biological process. When the protein has completed its role a protein phosphatase removes the phosphate and the protein reverts to its original state. This cycle takes place to control an enormous number of metabolic processes. For the key discovery of reversible protein phosphorylation, Fischer and Krebs were awarded the Nobel Prize for Physiology or Medicine in 1992. A protein kinase is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). ... Above is a ball-and-stick model of the inorganic hydrogenphosphate anion (HPO42−). Colour coding: P (orange); O (red); H (white). ... Adenosine 5-triphosphate (ATP), discovered in 1929 by Karl Lohmann,[1] is a multifunctional nucleotide primarily known in biochemistry as the molecular currency of intracellular energy transfer. ... A phosphatase is an enzyme that hydrolyses phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. ... 1992 (MCMXCII) was a leap year starting on Wednesday. ...


Krebs' interest in teaching and administration led him to leave the University of Washington to become the founding chairman of the Department of Biological Chemistry at the University of California, Davis. In 1977 he returned to the University of Washington as Chairman of the Department of Pharmacology.Other aspects of these chairmanships were also rewarding The University of California, Davis, commonly known as UC Davis[1], is a public, coeducational university located in Davis, California, which is about fifteen miles west of Sacramento in Californias Central Valley. ... For the album by Ash, see 1977 (album). ... Pharmacology (in Greek: pharmacon (φάρμακον) meaning drug, and logos (λόγος) meaning science) is the study of how substances interact with living organisms to produce a change in function. ...


References

  • Hughes, R. 1998. After the Prize
  • Krebs, E.G. Autobiography

 
 

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