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Encyclopedia > EC number

The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature, every EC number is associated with a recommended name for the respective enzyme. There are many different numbering schemes for assigning numbers to entities. ... Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ... A chemical reaction is a process that results in the interconversion of chemical substances [1]. The substance or substances initially involved in a chemical reaction are called reactants. ... Generic graph showing the effect of a catalyst in an hypotetical exothermic chemical reaction. ...


Every enzyme code consists of the letters "EC" followed by four numbers separated by periods. Those numbers represent a progressively finer classification of the enzyme. For example, the enzyme tripeptide aminopeptidase has the code "EC 3.4.11.4", whose components indicate the following groups of enzymes: EC 3 enzymes are hydrolases (enzymes that use water to break up some other molecule), EC 3.4 are hydrolases that act on peptide bonds, EC 3.4.11 enzymes are only those hydrolases that cleave off the amino-terminal amino acid from a polypeptide, and EC 3.4.11.4 are those that cleave off the amino-terminal end from a tripeptide. In biochemistry, a hydrolase is an enzyme that can break a chemical bond by hydrolysis. ... Water (from the Old English waeter; c. ... A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). ... An amino acid residue is what is left of an amino acid once a molecule of water has been lost (an H+ from the nitrogenous side and an OH- from the carboxylic side) in the formation of a peptide bond. ... Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ... A tripeptide is a peptide consisting of three amino acids, e. ...

Group Reaction catalyzed Typical reaction Enzyme example(s) with trivial name
EC 1
Oxidoreductases
To catalyze oxidation/reduction reactions; transfer of H and O atoms or electrons from one substance to another AH + B → A + BH (reduced)
A + O → AO (oxidized)
Dehydrogenase, oxidase
EC 2
Transferases
Transfer of a functional group from one substance to another. The group may be methyl-, acyl-, amino- or phospate group AB + C → A + BC Transaminase, kinase
EC 3
Hydrolases
Formation of two products from a substrate by hydrolysis AB + H2O → AOH + BH Lipase, amylase, peptidase
EC 4
Lyases
Non-hydrolytic addition or removal of groups from substrates. C-C, C-N, C-O or C-S bonds may be cleaved RCOCOOH → RCOH + CO2
EC 5
Isomerases
Intramolecule rearrangement, i.e. isomerization changes within a single molecule AB → BA Isomerase, mutase
EC 6
Ligases
Join together two molecules by synthesis of new C-O, C-S, C-N or C-C bonds with simultaneous breakdown of ATP X + Y+ ATP → XY + ADP + Pi Synthetase

[1] In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the oxidant, also called the hydrogen donor or electron donor) to another (the reductant, also called the hydrogen acceptor or electron acceptor). ... The most fundamental reactions in chemistry are the redox processes. ... Properties The electron is a lightweight fundamental subatomic particle that carries a negative electric charge. ... A dehydrogenase is an enzyme that oxidizes a substrate by transferring one or more protons and a pair of electrons to an acceptor, usually NAD/NADP or a flavin coenzyme such as FAD or FMN. Common examples of dehydrogenase enzymes in the TCA cycle are pyruvate dehydrogenase, isocitrate dehydrogenase, and... Headline text Bold textLink titleLink titleItalic textItalic textAn oxidase is any enzyme that catalyzes an oxidation/reduction reaction involving molecular oxygen (O2) as the electron acceptor. ... In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group (e. ... In organic chemistry functional groups are specific groups of atoms within molecules, that are responsible for the characteristic chemical reactions of those molecules. ... In biochemistry, a transaminase or an aminotransferase is an enzyme that catalyzes a type of reaction between an amino acid and an α-keto acid. ... In biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation. An enzyme that removes phosphate groups from targets is known as a phosphatase. ... In biochemistry, a hydrolase is an enzyme that can break a chemical bond by hydrolysis. ... Hydrolysis is a chemical process in which a molecule is split into two parts by the addition of a molecule of water. ... A lipase is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water–insoluble, lipid substrates. ... α-Amylase Amylase (EC 3. ... Peptidases (proteases [pronounced pro-tea-aces] and proteolytic enzymes are also commonly used) are enzymes which break peptide bonds of proteins. ... In biochemistry, a lyase is an enzyme that breaks various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure. ... In biochemistry, an isomerase is any enzyme that catalyses the interconversion of isomers. ... In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ... In biochemistry, an isomerase is any enzyme that catalyses the interconversion of isomers. ... An enzyme that catalyzes the shifting of a functional group from one position to another within the same molecule. ... In biochemistry, a ligase is an enzyme that can catalyse the joining of two molecules (ligation or gluing together) by forming a new chemical bond, with accompanying hydrolysis of ATP or other similar molecules. ... Covalently bonded hydrogen and carbon in a molecule of methane. ... Adenosine 5-triphosphate (ATP) is a multifunctional nucleotide primarily known in biochemistry as the molecular currency of intracellular energy transfer. ... In biochemistry, a ligase is an enzyme that can catalyse the joining of two molecules (ligation or glue together) by forming a new chemical bond, with concomitant hydrolysis of ATP or other similar molecules. ...


Strictly speaking, EC numbers do not specify enzymes, but enzyme-catalyzed reactions. If different enzymes (for instance from different organisms) catalyze the same reaction, then they receive the same EC number. UniProt identifiers uniquely specify a protein by its amino acid sequence.[2] UniProt is the universal protein database, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the worlds most comprehensive resource on protein information. ...


The enzyme nomenclature scheme was developed starting in 1955, when the International Congress of Biochemistry in Brussels set up an Enzyme Commission. The first version was published in 1961. The current sixth edition, published by the International Union of Biochemistry and Molecular Biology in 1992, contains 3196 different enzymes. 1955 (MCMLV) was a common year starting on Saturday of the Gregorian calendar. ... Hotel de Ville de Bruxelles Map showing the location of Brussels in Belgium Emblem of the Brussels-Capital Region Flag of The City of Brussels Brussels (Dutch: Brussel, pronounced ; French: Bruxelles, pronounced in Belgian French and often by non-Belgian speakers of French; German: Brüssel) is the capital of... 1961 (MCMLXI) was a common year starting on Sunday (the link is to a full 1961 calendar). ... Italic text ... 1992 (MCMXCII) was a leap year starting on Wednesday. ...


References

  1. ^ Moss, G.P.. Recommendations of the Nomenclature Committee. International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions they Catalyse. URL accessed on 2006-03-14.
  2. ^ ENZYME (Enzyme nomenclature database). ExPASy. URL accessed on 2006-03-14.

2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... March 14 is the 73rd day of the year in the Gregorian Calendar (74th in Leap years) with 292 days remaining in the year. ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... March 14 is the 73rd day of the year in the Gregorian Calendar (74th in Leap years) with 292 days remaining in the year. ...

See also


  Results from FactBites:
 
CAS registry number - Wikipedia, the free encyclopedia (419 words)
A CAS registry number is separated by hyphens into three parts, the first consisting of up to 6 digits, the second consisting of two digits, and the third consisting of a single digit serving as a check digit.
For example, the CAS number of water is 7732-18-5: the checksum is calculated as (8×1 + 1×2 + 2×3 + 3×4 + 7×5 + 7×6) = 105; 105 mod 10 = 5.
An example of a mixture with a CAS number is mustard oil (8007-40-7).
EC number - Wikipedia, the free encyclopedia (338 words)
The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze.
As a system of enzyme nomenclature, every EC number is associated with a recommended name for the respective enzyme.
Strictly speaking, EC numbers do not specify enzymes, but enzyme-catalyzed reactions.
  More results at FactBites »

 
 

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