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Encyclopedia > Droperidol
Droperidol
Systematic (IUPAC) name
1-[1-[4-(4-fluorophenyl)-4-oxo-butyl]- 3,6-dihydro-2H-pyridin-4-yl]- 3H-benzoimidazol- 2-one
Identifiers
CAS number 548-73-2
ATC code N01AX01 N05AD08
PubChem 3168
DrugBank APRD00939
Chemical data
Formula C22H22FN3O2 
Mol. mass 379.428 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 2.3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C (US) Image File history File links Size of this preview: 800 × 553 pixelsFull resolution (2145 × 1483 pixel, file size: 35 KB, MIME type: image/png) Structural formula of droperidol Self made in ChemDraw by Ben Benjah-bmm27 17:19, 4 March 2006 (UTC) File historyClick on a date/time to view... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, symbol, number carbon, C, 6 Chemical series nonmetals Group, period, block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number fluorine, F, 9 Chemical series halogens Group, Period, Block 17, 2, p Appearance Yellowish brown gas Atomic mass 18. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... The liver is an organ in vertebrates including humans. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... United States may refer to: Places: United States of America SS United States, the fastest ocean liner ever built. ...

Legal status
Routes Intraveneous, Intramuscular

Droperidol (Dropletan®, Dridol® or Inapsine®) is an antidopaminergic drug used as an antiemetic and antipsychotic. It was discovered at Janssen Pharmaceutica in 1961. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Intramuscular injection is an injection of a substance directly into a muscle. ... This page is a candidate to be moved to Wiktionary. ... It has been suggested that Blockbuster drug be merged into this article or section. ... An antiemetic is a drug that is effective against vomiting and nausea. ... Johnson & Johnson NYSE: JNJ is an international pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1885. ... Year 1961 (MCMLXI) was a common year starting on Sunday (link will display full calendar) of the Gregorian calendar. ...


Droperidol is a butyrophenone, and is a potent D2 (dopamine receptor) antagonist with some histamine and serotonin antagonist activity. It has a central antiemetic action and is frequently used in the treatment of postoperative nausea and vomiting in adult doses as low as 0.625 or 1.25 mg. The most successful treatment approaches combine the use of drugs, psychotherapy, and supportive therapy. ... This article or section does not cite any references or sources. ... Serotonin (pronounced ) (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. ... Postoperative nausea and vomiting is an unpleasant complication affecting about a third of the 10% of the population undergoing general anaesthesia each year. ...


It has also been used as an anti-psychotic in doses as high as 10mg i.m.


In 2001, the FDA changed the labeling requirements for droperidol injection, to include a so-called "Black Box Warning", citing concerns of QT prolongation and torsades de pointes. The evidence for this is disputed, with less than 20 reported cases of torsades in 30 years and most of those having received doses in excess of 50mg in a 24-hour period. It appears that the QT-prolongation is a dose-related effect and that in low doses, droperidol is not a significant risk. Torsades de pointes or torsades is a French term that literally means twisting of the points. It refers to a specific variety of ventricular tachycardia and its name is derived from a maneuver in ballet. ...


Some practitioners recommend the use of 0.5 mg to 1 mg I.V. for the treatment of vertigo in an otherwise healthy elderly patient who hasn’t responded to Epley maneuvers.


Side effects

If you experience any of the rare side-effects such as spasms of the face, one should have diphenhydramine (Benadryl®) injected into their IV to block the effects of the drug. If one is at home, fast acting Benadryl® dissolving mouth strips should be taken followed by a pill. Diphenhydramine hydrochloride (trade name Benadryl, as produced by J&J, or Dimedrol outside the U.S. & Canada. ...


References

  • Scuderi PE: Droperidol: Many questions, few answers. Anesthesiology 2003; 98: 289-90
  • Lischke V, Behne M, Doelken P, Schledt U, Probst S, Vettermann J. Droperidol causes a dose-dependent prolongation of the QT interval. Department of Anesthesiology and Resuscitation, Johann Wolfgang Goethe-University Clinics, Frankfurt am Main, Germany.
  • Emergency Medicine Magazine : http://www.emedmag.com/html/pre/tri/1005.asp

External links


  Results from FactBites:
 
ACS :: Cancer Drug Guide: droperidol (382 words)
Droperidol belongs to a general class of drugs called butyrophenones that are used to treat nausea and vomiting.
Droperidol is useful in preventing nausea and vomiting resulting from chemotherapy.
Droperidol is given as an injection in a vein or muscle.
Droperidol (569 words)
El droperidol o dehidrobenzolperidol es un neuroléptico antisicótico de corta acción derivado de la tetrahidroperidina de la familia de las butirofenonas.
La absorción del droperidol por vía intramuscular e incluso por vía oral es rápida (20 y 60 minutos).
Esta dosis débiles de droperidol deben tenerse en cuenta en la cirugía ambulatoria, ya que pueden disminuir los test de aptitud y producir fenómenos extrapiramidales.
  More results at FactBites »

 
 

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