Dolasetron is a drug used to treat nausea following chemotherapy. Generally one takes one tablet in the morning for each of the two days following chemotherapy. A drug is any substance that can be used to modify a chemical process or processes in the body, for example to treat an illness, relieve a symptom, enhance a performance or ability, or to alter states of mind. ... Nausea (Greek ÎÎ±Ï ÏÎµÎ¯Î±) is the sensation of unease and discomfort in the stomach with an urge to vomit. ... Chemotherapy is the use of chemical substances to treat disease. ... For other meanings please see Tablet (disambiguation) Common disk-shaped pills A pharmacological tablet is a medicinal or other active substance mixed with binder powders and pressed into a tablet form. ...
Dolasetron and its active metabolite, hydrodolasetron (MDL 74156), are selective 5-HT receptor antagonists shown not to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
However, dolasetron is not recommended in patients with severe renal impairment because of the possibility of prolonged QTc intervals and other cardiac conduction abnormalities from elevated hydrodolasetron levels.
Dolasetron did not inhibit the antitumor activity of 4 chemotherapeutic agents (cisplatin, 5-fluorouracil, doxorubicin, cyclophosphamide) in 4 murine models.
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